Technological advances in brain imaging, genetics, and computational modeling have set the stage for novel insights into the cognitive neuroscience of human development during childhood and adolescence. As the field has expanded, research in this area increasingly incorporates highly interdisciplinary approaches utilizing sophisticated imaging, behavioral, and genetic methodologies to map brain, cognitive, and affective/social development. The articles in this Research Topic will highlight both the recent advances and future challenges inherent in this burgeoning interdisciplinary field. We invite both review articles and original research reports that consider any of the broad spectrum of topics within the field of developmental cognitive neuroscience.

The Developing Human Brain: Growth and Epidemiologic Neuropathology presents the analyses that study the conditions and events of pregnancy, labor, and delivery as they relate to neuropathological outcomes. This book reviews the weaknesses and strengths of epidemiologic methods applied to autopsy populations and provide the details of the neuropathologic sample. Organized into three sections encompassing 27 chapters, this book begins with an overview of the hypotheses about the relationships between potential antecedents and morphologic events that can subsequently be tested in the living child using specific measure of cerebral or neurologic function. This text then examines the general principles of epidemiology. Other chapters consider the advantages and disadvantages of using autopsy data for epidemiologic studies. This book discusses as well the statistical and descriptive methods used to provide a panoramic view of the developing human brain based on infants aborted at different stages of development. The final chapter deals with anatomical changes at the final months of the second trimester. This book is a valuable resource for neuropathologists, neurologists, and pathologists.

The human brain is extraordinary complex and yet its origin is a simple tubular structure. Rapid and dramatic structural growth takes place during the fetal and perinatal period. By the time of birth, a repertoire of major cortical, subcortical and white matter structures resembling the adult pattern has emerged, however there are continued maturational changes of the gray matter and white matter throughout childhood and adolescence and into adulthood. The maturation of neuronal structures provides the neuroanatomical basis for the acquisition and refinement of cognitive functions during postnatal development. Histological imaging has been traditionally dominant in understanding neuroanatomy of early brain development and still plays an unparalleled role in this field. Modern magnetic resonance imaging (MRI) techniques including diffusion MRI, as noninvasive tools readily applied to in vivo brains, have become an important complementary approach in revealing the detailed brain anatomy, including the structural connectivity between brain regions. In this research topic, we presented the most recent investigations on understanding the neuroanatomy and connectivity of human brain development using both histology and MRI. Modern advances in mapping normal developmental brain anatomy and connectivity should elucidate many neurodevelopmental disorders, ranging from rare congenital malformations to common disorders such as autism and attention deficit hyperactivity disorder (ADHD), which is a prerequisite for better diagnosis and treatment of these currently poorly understood diseases.

The new edition of The Embryonic Human Brain: An Atlas of Developmental Stages represents the integration of analysis of the serial sections of human embryos in the Carnegie collection with results of the latest ultrasound studies. It provides summaries of the morphological status of the brain at each stage of development, covering both normal and anomalous conditions. Preceding the atlas are several chapters that present historical aspects, techniques, and prenatal measurements, as well as an introduction to embryonic staging, and terminology accompanied by over definitions of key terms. Now illustrated in full colour throughout Includes high quality photographs, photomicrographs, and diagrams Expands coverage of magnetic resonance imaging of the fetal and perinatal periods Highlights molecular and genetic aspects of normal and abnormal development of the brain Utilizes a set of standardized abbreviations Provides selected references to seminal studies Review for the Second Edition: "[A] really beautiful and wonderfully informative book that no embryologist, comparative anatomist, pediatric neurologist or neurosurgeon should be without. Putting aside the medical relevance of this atlas, it also provides the most captivating version of one of the most complex and fascinating embryological stories of all.” BRAIN This atlas is an invaluable resource for neuroscientists, developmental biologists, comparative anatomists, neurologists, pathologists, radiologists, and neurosurgeons.

This book is unique among the current literature in that it systematically documents the prenatal structural development of the human brain. It is based on lifelong study using essentially a single staining procedure, the classic rapid Golgi procedure, which ensures an unusual and desirable uniformity in the observations. The book is amply illustrated with 81 large, high-quality color photomicrographs never previously reproduced. These photomicrographs, obtained at 6, 7, 11, 15, 18, 20, 25, 30, 35, and 40 weeks of gestation, offer a fascinating insight into the sequential prenatal development of neurons, blood vessels, and glia in the human brain.

Susan Greenfield, one of the world's pre-eminent scientists, takes the reader on a guided tour of the final frontier in human understanding: the brain. Locked away remote from the rest of the body in its own custom-built casing of skull bone, with no intrinsic moving parts, the human brain remains a tantalising mystery. But now, more than ever before, we have the expertise to tackle this mystery - the last 20 years have seen astounding progress in brain research. Susan Greenfield begins by exploring the roles of different regions of the brain. She then switches to the opposite direction and examines how certain functions, such as movement and vision, are accommodated in the brain. She describes how a brain is made from a single fertilized egg, and the fate of the brain is traced through life as we see how it constantly changes as a result of experience to provide the essence of a unique individual.

What would you see if you removed the skull from the human brain and then slowly worked your way deeper and deeper into the brain, to the level of an individual neuron? With renowned brain researcher Susan Greenfield as your guide, here is your chance to gain a bird's eye view of the human brain—and to learn more about what the brain is, how it works, what happens when one part of the brain is made dysfunctional through stroke or accident, how brain mood-modifying drugs find their targets.In a particularly fascinating chapter, Greenfield surveys for us how a brain is built and then takes us on a tour of the developing brain from the moment of conception.Throughout Greenfield poses the larger questions all readers want to consider, including: At what stage does individuality creep into the developing brain? How does the collection of circuits of neurons give rise not just to an individual brain but an individual consciousness? What might a fetus be conscious of?

This comprehensive atlas depicts the entire range of normal variants seen on neuroradiologic images, helping radiologists "decode" appearances that can be misdiagnosed as pathology. The book features nearly 900 radiographs that show normal variants seen on plain film, MR, CT, and angiographic images, plus accompanying line drawings that demonstrate normal angiogram patterns and other pertinent anatomy.Dr. Jinkins, a well-known neuroradiologist, takes a multimodality approach to the cranium, sella, orbit, face, sinuses, neck, and spine. In an easy-to-follow format, he provides the information radiologists need to identify unusual features...assess their significance...avoid unnecessary, expensive studies...and minimize exposure and risk.

This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.