The present monograph analyses the FitzHugh-Nagumo (F-N) model Le. , the Cauchy problem for some generalized Van der Pol equation depending on three real parameters a, band c. This model, given in (1. 1. 17), governs the initiation of the cardiac impulse. The presence of the three parameters leads to a large variety of dy namics, each of them responsible for a specific functioning of the heart. For physiologists it is highly desirable to have aglobai view of all possible qualitatively distinct responses of the F-N model for all values of the pa rameters. This reduces to the knowledge of the global bifurcation diagram. So far, only a few partial results appeared and they were spread through out the literature. Our work provides a more or less complete theoretical and numerical investigation of the complex phase dynamics and bifurca tions associated with the F-N dynamical system. This study includes the static and dynamic bifurcations generated by the variation of a, band c and the corresponding oscillations, of special interest for applications. It enables one to predict all possible types of initiations of heart beats and the mechanism of transformation of some types of oscillations into others by following the dynamics along transient phase space trajectories. Of course, all these results hold for the F-N model. The global phase space picture enables one to determine the domain of validity of this model.

This book and its sister volumes constitute the proceedings of the 2nd International Symposium on Neural Networks (ISNN 2005). ISNN 2005 was held in the beautiful mountain city Chongqing by the upper Yangtze River in southwestern China during May 30–June 1, 2005, as a sequel of ISNN 2004 successfully held in Dalian, China.

Covers the fundamental concepts and mathematical skills required to analyse reaction-diffusion models for biological populations. Focuses on mathematical modeling and numerical simulations using basic conceptual and classic models of population dynamics, Virus and Brain dynamics. Covers wide range of models using spatial and non-spatial approaches. Covers single, two and multispecies reaction-diffusion models from ecology and models from bio-chemistry. Uses Mathematica for problem solving and MATLAB for pattern formations. Contains solved Examples and Problems in Exercises.

This book constitutes, together with its compagnion LNCS 1606, the refereed proceedings of the International Work-Conference on Artificial & Neural Networks, IWANN'99, held in Alicante, Spain in June 1999. The 91 revised papers presented were carefully reviewed & selected for inclusion in the book. This volume is devoted to applications of biologically inspired artificial neural networks in various engineering disciplines. The papers are organized in parts on artificial neural nets simulation & implementation, image processing & engineering applications.

This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism. Geneviève Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Université Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbrück Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.

Gathering the proceedings of the 11th CHAOS2018 International Conference, this book highlights recent developments in nonlinear, dynamical and complex systems. The conference was intended to provide an essential forum for Scientists and Engineers to exchange ideas, methods, and techniques in the field of Nonlinear Dynamics, Chaos, Fractals and their applications in General Science and the Engineering Sciences. The respective chapters address key methods, empirical data and computer techniques, as well as major theoretical advances in the applied nonlinear field. Beyond showcasing the state of the art, the book will help academic and industrial researchers alike apply chaotic theory in their studies.

This book provides a complete study on neural structures exhibiting nonlinear and stochastic dynamics, elaborating on neural dynamics by introducing advanced models of neural networks. It overviews the main findings in the modelling of neural dynamics in terms of electrical circuits and examines their stability properties with the use of dynamical systems theory. It is suitable for researchers and postgraduate students engaged with neural networks and dynamical systems theory.

Gathering the proceedings of the 13th CHAOS2020 International Conference, this book highlights recent developments in nonlinear, dynamical and complex systems. The conference was intended to provide an essential forum for Scientists and Engineers to exchange ideas, methods, and techniques in the field of Nonlinear Dynamics, Chaos, Fractals and their applications in General Science and the Engineering Sciences. The respective chapters address key methods, empirical data and computer techniques, as well as major theoretical advances in the applied nonlinear field. Beyond showcasing the state of the art, the book will help academic and industrial researchers alike apply chaotic theory in their studies.

The burgeoning field of data analysis is expanding at an incredible pace due to the proliferation of data collection in almost every area of science. The enormous data sets now routinely encountered in the sciences provide an incentive to develop mathematical techniques and computational algorithms that help synthesize, interpret and give meaning to the data in the context of its scientific setting. A specific aim of this book is to integrate standard scientific computing methods with data analysis. By doing so, it brings together, in a self-consistent fashion, the key ideas from: · statistics, · time-frequency analysis, and · low-dimensional reductions The blend of these ideas provides meaningful insight into the data sets one is faced with in every scientific subject today, including those generated from complex dynamical systems. This is a particularly exciting field and much of the final part of the book is driven by intuitive examples from it, showing how the three areas can be used in combination to give critical insight into the fundamental workings of various problems. Data-Driven Modeling and Scientific Computation is a survey of practical numerical solution techniques for ordinary and partial differential equations as well as algorithms for data manipulation and analysis. Emphasis is on the implementation of numerical schemes to practical problems in the engineering, biological and physical sciences. An accessible introductory-to-advanced text, this book fully integrates MATLAB and its versatile and high-level programming functionality, while bringing together computational and data skills for both undergraduate and graduate students in scientific computing.

This book is about the dynamics of neural systems and should be suitable for those with a background in mathematics, physics, or engineering who want to see how their knowledge and skill sets can be applied in a neurobiological context. No prior knowledge of neuroscience is assumed, nor is advanced understanding of all aspects of applied mathematics! Rather, models and methods are introduced in the context of a typical neural phenomenon and a narrative developed that will allow the reader to test their understanding by tackling a set of mathematical problems at the end of each chapter. The emphasis is on mathematical- as opposed to computational-neuroscience, though stresses calculation above theorem and proof. The book presents necessary mathematical material in a digestible and compact form when required for specific topics. The book has nine chapters, progressing from the cell to the tissue, and an extensive set of references. It includes Markov chain models for ions, differential equations for single neuron models, idealised phenomenological models, phase oscillator networks, spiking networks, and integro-differential equations for large scale brain activity, with delays and stochasticity thrown in for good measure. One common methodological element that arises throughout the book is the use of techniques from nonsmooth dynamical systems to form tractable models and make explicit progress in calculating solutions for rhythmic neural behaviour, synchrony, waves, patterns, and their stability. This book was written for those with an interest in applied mathematics seeking to expand their horizons to cover the dynamics of neural systems. It is suitable for a Masters level course or for postgraduate researchers starting in the field of mathematical neuroscience.