This Research Topic celebrates the 50th anniversary of the first heart transplant performed in December of 1967 in Cape Town, South Africa. Cardiovascular researchers met in South Africa in December 2017 to commemorate this event, presenting an opportune time to reflect on the achievements of applied cardiovascular research and highlight forthcoming technology developments that will shape the future of cardiovascular medicine. The clinical breakthrough in 1967 offered hope to many patients suffering with cardiac complications, and these life-saving surgeries continue to have a tremendous impact. Tissue shortages, surgical risks, and complications due to improper host-transplant tissue interactions, however, limit the utility of heart transplants to the most severe cases of cardiac morbidity. Recent advances have yielded mechanistic insight into the factors that control cardiovascular tissue maintenance and remodeling. The field of regenerative medicine seeks to control these factors to promote in situ tissue regeneration or engineered tissue replacement. These exciting new technologies could lead to a renaissance in the treatment of many cardiovascular diseases, just as the realization of heart transplantation 50 years ago. In this Research Topic, researchers and clinicians from regenerative medicine and applied cardiovascular biology provide literature reviews and original manuscripts to demonstrate the trajectory of cardiovascular medicine. The contributions vertically integrate advances by clinicians, engineers, and basic scientists, all researching similar topics from different angles and with complementary perspectives. Taken together, these contributions demonstrate the process of applied cardiovascular research from basic science discoveries to implementation in clinical practice.

This major collection contains selected papers from the third Public Law Conference, an international conference hosted by the University of Melbourne in July 2018. The collection includes contributions by leading academics and senior judges from across the common law world, including Australia, Canada, New Zealand, the United Kingdom and the United States. The collection explores the frontiers of public law, examining cutting-edge issues at the intersection of public law and other fields. The collection addresses four principal frontiers: public law and international law; public law and indigenous peoples; public law and other domestic fields, specifically criminal law and private law; and public law and public administration. In common with the two books from the previous Public Law Conferences, this collection offers authoritative insights into the most important issues emerging in public law, and is essential reading for those working in the field.

This volume presents contributions by a galaxy of eminent scientists and technologists from the world over in broad spectrum of areas in materials science, providing a global perspective on complex issues of current concern and the direction of research in these areas.

Probing the Frontiers of Biblical Studies is a seventeen-chapter anthology on biblical studies. It has been crafted as an extended and respectful thank you note to one of the most insightful scholars of biblical studies, David J. A. Clines of Sheffield University in England. He is credited with providing guidance to, and shaping the thought of, two generations of scholars who focus on essential approaches to understanding the Bible, with particular attention given to the Old Testament and allied literature. The anthology is directed toward those readers with pastoral, analytical, ancient intercultural, as well as contemporary cultural perspectives. Essays address a wide range of topics: the so-called Documentary Hypothesis, prophecy, divination, and magic, the wisdom themes in the Book of Job, the Egyptian influence on New Testament, the issue of non-sexual love between two men during combat conditions, character development in a biblical novella, rhetorical questions and their role in the Psalter, and the ways of God in the world. By combining these various topics, Probing the Frontier of Biblical Studies has addressed many of the outstanding issues in Old Testament study and ancillary disciplines.

Frontiers in Cardiovascular Drug Discovery is an eBook series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The eBook series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. The fourth volume of the series covers the following topics: -Aspirin administration -Adenosine receptor targeting for cardiovascular therapy -Drug treatment of patients with coronary stenting -Immunosuppressive drugs in heart transplantation -PCSK9 inhibition for lowering LDL-C levels.

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The seventh volume of this series features reviews on roles of mesenchymal stem cells and biomaterials in cartilage regeneration in vivo, liver regeneration, cardiogenesis and magnetic nanoparticles for regenerative therapy.

"This is by far the best book I've read on the science of aging."—Andrew Weil, M.D. "Life-span Truth Will Set You Free from Age-old Worries," announced the Chicago Tribune upon the first publication of this book. The New England Journal of Medicine confirmed, "For readers interested in aging and longevity, this small book clearly explains the major concepts...extremely enjoyable to read." From NBC Nightly News with Tom Brokaw to Scientific American to the New York Times, S. Jay Olshansky and Bruce A. Carnes have stirred up controversy and brought clarity to an issue often muddled by exaggeration and pseudoscience. Medical science has uncovered a host of answers to the problems of aging, but many of the most exciting discoveries are buried in scientific journals or overshadowed by popular quick-fix treatments. The Quest for Immortality explains the real science of aging and shows which treatments offered by today's multi-billion-dollar anti-aging industries offer real hope, and which are a waste of money and time.

"This volume presents a collection of thirteen papers from the Fourth International Conference on the Ancient Novel (ICAN 2008), which was held in Lisbon at the Fundacao Calouste Gulbenkian from July 21 to 26, 2008. The Ancient Novel and the Frontiers of Genre reflects entirely the spirit and the general theme of the Conference, and is intended to convey the idea that both the novel as a literary form and scholarship on the ancient novel tend to mature and advance by crossing boundaries that older forms regarded as uncrossable. The papers assembled in this volume include extended prose narratives of all kinds and thereby widen and enrich the scope of the novel's canon. The essays explore a wide variety of text, crossed genres, and hybrid forms, which transgress the frontiers of the so-called ancient novel, providing an excellent insight into different kinds of narrative prose in antiquity". (from the preface)