Dr. Quigley has created a must-have reference on the gut microbiome for the practicing gastroenterologist. A leader in the field of human physiology and digestive disorders, he has laid out the basics on this increasingly important topic, devoting articles to the organization and biology of the human gut microbiome as well as its diagnostic potential. Top international authors have presented articles that discuss the intersection of the gut microbiome and diet and the gut-brain axis. Clinical implications of the gut microbiome are discussed with disease states like IBD, GI cancer, and liver diseases. Finally, the issue ends with the cutting-edge clinical innovation of fecal microbial transplantation. This issue bridges the gap between science and clinical practice and should be an important reference to practicing gastroenterologists.

In this issue of Gastroenterology Clinics, guest editor William Chey brings his considerable expertise to the topic of Irritable Bowel Syndrome. - Provides in-depth, clinical reviews on IBS, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Gastroenterology Clinics, Guest Editors M. Nedim. N. Ince and David E. Elliott bring their considerable expertise to the topic of Gastrointestinal Infections. Top experts in the field cover key topics such as Candida esophagitis, Acute bacterial gastroenteritis, Clostridium difficile infection and antibiotic-associated diarrhea, and more. - Provides concise and comprehensive coverage of the issues physicians face every day. - Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field. - Contains 14 relevant, practice-oriented topics including Helicobacter pylori infection; Viral gastroenteritis in special patient populations; Rare causes of hepatitis; Postinfectious irritable bowel syndrome; and more.

The goal of this issue of Gastroenterology Clinics is to present GI diseases which affect women uniquely, such as pelvic floor problems and pregnancy related disorders, or which require a more considered approach such as functional bowel disease or autoimmune processes. It will also address the position of women and female gastroenterologists in the health system as a whole. This issue is published at an exciting, transitional time in the future of gastroenterology, as we adjust approaches for the assessment of disease in a large portion of our patient population, and as we address the challenges in practicing medicine based on the uniqueness of specific populations.

With collaboration of Consulting Editor, Dr. Alan Buchman, Guest Editors Drs. Gerard Mullen and Berkeley Limketkai have created a practical and current issue covering the breadth of topics in nutrition and gastrointestinal disease. Articles are specifically devoted to the following topics: Nutrition in the Management of Inflammatory Bowel Diseases; Irritable Bowel Syndrome: Food as a Friend or Foe; Treatment of Obesity: Beyond the Diet; Nutritional Management of Acute Pancreatitis; Nutritional Care in Patients with Intestinal Failure; The Life-long Role of Nutrition on the Gut Microbiome and Gastrointestinal Disease; Nutritional Strategies for Esophageal Disorders; Precision Medicine in Obesity; Gastrointestinal Food Allergies and Intolerances; All Things Gluten; Fish Oil for Inflammatory Bowel Disease: Panacea or Placebo; Nutrition Tools for the Practicing Gastroenterologist; Colorectal Cancer and Diet: Is Diet an Intervention; Non-Alcoholic Fatty Liver Disease: Nutritional Considerations; and Nutritional Considerations in the Hospital Setting. Readers will come away with current clinical information that they can employ in the clinical setting to improve outcomes in patients with gastrointestinal diseases.

The Guest Editor, Dr. Robert J. Shulman, and Consulting Editor, Dr. Alan Buchman, have created a thorough review of the current clinical updates on treating children with gastrointestinal disorders and diseases. Expert authors have submitted review articles on the following topics: Update on Diet Management of Functional GI Disorders; Brain-Gut Axis: Clinical Implications; Pancreatitis: Molecular Mechanisms and Management; Inflammatory Bowel Disease: What Very Early Onset Disease Teaches Us; GI Development: Implications for Management of the Preterm and Term Infant; Infectious Diarrhea: New and Emerging Issues; New Insights into the Pathogenesis and Treatment of Malnutrition; Infantile Colic: New Insights into an Old Problem; Constipation: Beyond the Old Paradigms; Integration of Biomedical and Psychosocial Treatments in Functional GI Disorders; GI Neuropathies: New Insights and Emerging Therapies; Food Sensitivities: Fact versus Fiction; IBD in Children: A Focus on Quality Improvement and Pediatric Focused Care; Molecular Advances in the Understanding of Pediatric Cholestasis; Assessment and Treatment of Nonadherence in Transplant Recipients; and Update on Fatty Liver Disease in Children. Readers will come away with the current updates they need to diagnose and treat pediatric patients and improve outcomes.

In this issue of Gastroenterology Clinics, guest editor Dr. Alan L. Buchman brings his considerable expertise to the topic of Advances in Intestinal Transplantation, Part II. In this second of two issues devoted to the comprehensive coverage of this topic, top experts discuss the complexities of intestinal failure (IF) and provide a better understanding of medical and surgical management. Coverage also includes assessment of when patients should be referred to select centers of expertise where both medical and surgical (nontransplant and transplant) modalities are available. - Contains 12 relevant, practice-oriented topics including innate and cellular immune responses in intestinal transplantation: new discoveries: altering the microbiome and implications for host metabolomics; vaccines and vaccine response: other maintenance care in the small bowel transplant patient; living donor intestinal transplantation; the stem cell niche in short bowel syndrome; and more. - Provides in-depth clinical reviews on advances in intestinal transplantation, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Helicobacter pylori (H. pylori) infection is a worldwide disease with a significant morbidity and mortality; it is the leading cause of non-ulcer dyspepsia, peptic ulcers and gastric tumors, including low-grade mucosa-associated lymphoid tissue-lymphoma and adenocarcinoma. In addition, it has also been recognized that the interaction between H. pylori and non-steroidal, anti-inflammatory drugs is damaging to the gastroduodenal mucosa. H. pylori treatment still remains a challenge for physicians, since no current first-line therapy is able to cure the infection in all treated patients. This issue will serve to update gastroenterologists on current therapies, evaluation and management of disease progression, and the future of management of H. pylori infection.

Together with Consulting Editor, Dr. Alan Buchman, Dr. Scott Lee has put together a state-of-the-art issue of Gastroenterology Clinics devoted to Ulcerative Colitis (UC). He has selected expert authors to contribute clinical reviews that provide the latest clinical findings and recommendations. Articles are devoted to the following topics: Epidemiology and pathogenesis of UC; Making initial diagnosis of UC and ruling out other diseases that mimic UC; Assessing severity of disease; Initial medical treatment of UC; Treatment of UC with steroids; Biologic therapy in UC; Non-biologic immune suppression in UC; Microbiome and fecal transplant in UC; Health maintenance in UC, including bone density scan, vaccination recommendations, cancer screening; Women's issues and UC; Risk of colon cancer and recommended surveillance strategies in UC patients; Surgical management of UC, indications and outcomes from colectomy; and Management of J-pouches. Readers will come away with the latest clinical recommendations they need to improve outcomes in patients with UC.

In this issue of Diagnosis and Treatment of Gastrointestinal Cancers, guest editors Drs. Marta Davila and Raquel E. Davila bring their considerable expertise to the topic of Diagnosis and Treatment of Gastrointestinal Cancers. The early detection, diagnosis, and accurate staging of GI cancers, along with enhanced imaging techniques, new therapies, and a greater understanding of GI tumors at the molecular level, has revolutionized the approach to GI cancer patients in recent years. In this issue, distinguished authors recognized internationally as leading authorities in the field provide an exhaustive review of the latest topics in GI cancer. - Contains 13 practice-oriented topics including management of Barrett's esophagus and early esophageal adenocarcinoma; familial pancreatic cancer; colorectal cancer: screening and early detection; the microbiome in gastrointestinal cancers; and more. - Provides in-depth clinical reviews on diagnosis and treatment of gastrointestinal cancers, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.