This important new book documents a major breakthrough in the treatment of the three most widespread learning disabilities--ADHD, dyslexia, and dyspraxia ("clumsy child syndrome"). Although these conditions have reached epidemic proportions, treatment has been limited to ineffective behavioral therapies or the controversial prescription drug Ritalin. Now Dr. B. Jacqueline Stordy, a leading researcher in the field, reveals a stunning new treatment based on a simple nutritional supplement: LCP (long chain polyunsaturated fatty acids). The LCP Solution is the first book to describe this new natural treatment and to explain how children (and adults) can incorporate it into their daily lives. As a member of a family with a long history of dyslexia, Dr. Stordy discovered in a pioneering experiment that dyslexic and dyspraxic children who began taking a dietary supplement consisting of LCP experienced dramatic transformations in the quality of their lives. At the same time, parallel studies conducted at Purdue University came up with similar results with children who had ADHD. The effect of this dietary supplement was nothing short of revolutionary: after only a few weeks, dyslexic and ADHD children became calmer, more focused, easier to teach, while dyspraxics improved significantly in dexterity and balance, showing markedly less anxiety. In The LCP Solution, Dr. Stordy documents how this life-changing treatment came about and explains step-by-step how sufferers of each of the three major conditions can use it to change their lives at home, at school, and at work. Illuminating, vividly presented, and authoritative in its findings, this book will revolutionize our approach to learning disabilities. LCPs are natural, simple to use, and amazing in their benefits. If you or someone you love suffers from a learning disability, this book is essential reading.

A revised edition of the standard reference on the linear complementarity problem.

Biomarker discovery is an important area of biomedical research that may lead to significant breakthroughs in disease analysis and targeted therapy. Biomarkers are biological entities whose alterations are measurable and are characteristic of a particular biological condition. Discovering, managing, and interpreting knowledge of new biomarkers are challenging and attractive problems in the emerging field of biomedical informatics. This volume is a collection of state-of-the-art research into the application of data mining to the discovery and analysis of new biomarkers. Presenting new results, models and algorithms, the included contributions focus on biomarker data integration, information retrieval methods, and statistical machine learning techniques. This volume is intended for students, and researchers in bioinformatics, proteomics, and genomics, as well engineers and applied scientists interested in the interdisciplinary application of data mining techniques.

In complementarity theory, which is a relatively new domain of applied mathematics, several kinds of mathematical models and problems related to the study of equilibrium are considered from the point of view of physics as well as economics. In this book the authors have combined complementarity theory, equilibrium of economical systems, and efficiency in Pareto's sense. The authors discuss the use of complementarity theory in the study of equilibrium of economic systems and present results they have obtained. In addition the authors present several new results in complementarity theory and several numerical methods for solving complementarity problems associated with the study of economic equilibrium. The most important notions of Pareto efficiency are also presented. Audience: Researchers and graduate students interested in complementarity theory, in economics, in optimization, and in applied mathematics.

This book, intended for people in engineering and fundamental sciences, presents an integrated mathematical methodology for advanced dynamics and control of structures and machines, ranging from the derivation of models up to the control synthesis problem. This point of view is particularly useful as the physical insight and the associated structural properties, related e.g. to the Lagrangian or Hamiltonian framework, can be advantageously utilized. To this end, up to date results in disciplines like continuum mechanics, analytical mechanics, thermodynamics and electrodynamics are presented exploiting the differential geometric properties, with the basic notions of this coordinate-free approach revisited in an own chapter. In order to illustrate the proposed methodologies, several industrial applications, e.g., the derivation of exact solutions for the deformation compensation by shaped actuation in elastic bodies, or the coordination of rigid and flexible joint robots, are discussed.

By having its origin in analytical and continuum mechanics, as well as in computer science and applied mathematics, multibody dynamics provides a basis for analysis and virtual prototyping of innovative applications in many fields of contemporary engineering. With the utilization of computational models and algorithms that classically belonged to different fields of applied science, multibody dynamics delivers reliable simulation platforms for diverse highly-developed industrial products such as vehicle and railway systems, aeronautical and space vehicles, robotic manipulators, smart structures, biomechanical applications and nano-technologies. The chapters of this volume are based on the revised and extended versions of the selected scientific papers from amongst 255 original contributions that have been accepted to be presented within the program of the distinguished international ECCOMAS conference. It reflects state-of-the-art in the advances of multibody dynamics, providing excellent insight in the recent scientific developments in this prominent field of computational mechanics and contemporary engineering.

This book constitutes the refereed proceedings of the 4th International Workshop on Internet and Network Economics, WINE 2008, held in Shanghai, China, in December 2008. The 68 revised full papers presented together with 10 invited talks were carefully reviewed and selected from 126 submissions. The papers are organized in topical sections on market equilibrium, congestion games, information markets, nash equilibrium, network games, solution concepts, algorithms and optimization, mechanism design, equilibrium, online advertisement, sponsored search auctions, and voting problems.

In January 1992, the Sixth Workshop on Optimization and Numerical Analysis was held in the heart of the Mixteco-Zapoteca region, in the city of Oaxaca, Mexico, a beautiful and culturally rich site in ancient, colonial and modern Mexican civiliza tion. The Workshop was organized by the Numerical Analysis Department at the Institute of Research in Applied Mathematics of the National University of Mexico in collaboration with the Mathematical Sciences Department at Rice University, as were the previous ones in 1978, 1979, 1981, 1984 and 1989. As were the third, fourth, and fifth workshops, this one was supported by a grant from the Mexican National Council for Science and Technology, and the US National Science Foundation, as part of the joint Scientific and Technical Cooperation Program existing between these two countries. The participation of many of the leading figures in the field resulted in a good representation of the state of the art in Continuous Optimization, and in an over view of several topics including Numerical Methods for Diffusion-Advection PDE problems as well as some Numerical Linear Algebraic Methods to solve related pro blems. This book collects some of the papers given at this Workshop.

Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.

The use of optimization techniques has become integral to the design and analysis of most industrial and socio-economic systems. Great strides have been made recently in the solution of large-scale problems arising in such areas as production planning, airline scheduling, government regulation, and engineering design, to name a few. Analysts have found, however, that standard mathematical programming models are often inadequate in these situations because more than a single objective function and a single decision maker are involved. Multiple objective programming deals with the extension of optimization techniques to account for several objective functions, while game theory deals with the inter-personal dynamics surrounding conflict. Bilevel programming, the focus of this book, is in a narrow sense the combination of the two. It addresses the problern in which two decision makers, each with their individual objectives, act and react in a noncooperative, sequential manner. The actions of one affect the choices and payoffs available to the other but neither player can completely dominate the other in the traditional sense.