According to Pliny's definition, Natural History is a book about the natural world or life. It is the first encyclopedic work in history and a model for later encyclopedias. It is also the largest single work to have survived from the Roman Empire to the modern days. In this book, Pliny covers topics including astronomy, mathematics, geography, ethnography, anthropology, human physiology, zoology, botany, agriculture, horticulture, pharmacology, mining, mineralogy, sculpture, art, and precious stones. In total, the book consists of 10 volumes which contain 37 books. For Pliny, nature was divine. It was a pantheistic concept inspired by the Stoic philosophy. Also, according to this philosophy, the components of nature are described with a view to their role in human life. Pliny devotes a number of the books to plants, focusing on their medicinal value; the books on minerals include descriptions of their uses in architecture, sculpture, art, and jewelry.

The most important surviving encyclopedia from the ancient world, Pliny the Elder's Natural History is unparalleled as a guide to the cultural meanings of everyday things in first-century Rome. As part of a new direction in classical scholarship, Trevor Murphy reads the work not just for the information it contains, but to understand how and why Pliny collects and presents information as he does. Concentrating on the geographic and ethnographic information in Pliny, Murphy demonstrates the work's political importance. The selection and arrangement of the encyclopedia's material show that it is more than an instrument of reference: it is a monument to the power of Roman imperial society.

Pliny's Natural History is an astonishingly ambitious work that ranges from astronomy to art and from geography to zoology. Mingling acute observation with often wild speculation, it offers a fascinating view of the world as it was understood in the first century AD, whether describing the danger of diving for sponges, the first water-clock, or the use of asses' milk to remove wrinkles. Pliny himself died while investigating the volcanic eruption that destroyed Pompeii in AD 79, and the natural curiosity that brought about his death is also very much evident in the Natural History - a book that proved highly influential right up until the Renaissance and that his nephew, Pliny the younger, described 'as full of variety as nature itself'.

One of the earliest surviving examples of 'art history', Pliny the Elder's 'chapters on art' form part of his encyclopaedic Natural History, completed shortly before its author died during the eruption of Vesuvius in AD 79. This important new work argues that the Natural History offers a sophisticated account of the world as empire, in which art as much as geography can be used to expound a Roman imperial agenda. Reuniting the 'chapters on art' with the rest of the Natural History, Sorcha Carey considers how the medium of the 'encyclopaedia' affects Pliny's presentation of art, and reveals how art is used to explore themes important to the work as a whole. Throughout, the author demonstrates that Pliny's 'chapters on art' are a profoundly Roman creation, offering an important insight into responses to art and culture under the early Roman empire.

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