The Statistical Analysis of Multivariate Failure Time Data: A Marginal Modeling Approach provides an innovative look at methods for the analysis of correlated failure times. The focus is on the use of marginal single and marginal double failure hazard rate estimators for the extraction of regression information. For example, in a context of randomized trial or cohort studies, the results go beyond that obtained by analyzing each failure time outcome in a univariate fashion. The book is addressed to researchers, practitioners, and graduate students, and can be used as a reference or as a graduate course text. Much of the literature on the analysis of censored correlated failure time data uses frailty or copula models to allow for residual dependencies among failure times, given covariates. In contrast, this book provides a detailed account of recently developed methods for the simultaneous estimation of marginal single and dual outcome hazard rate regression parameters, with emphasis on multiplicative (Cox) models. Illustrations are provided of the utility of these methods using Women’s Health Initiative randomized controlled trial data of menopausal hormones and of a low-fat dietary pattern intervention. As byproducts, these methods provide flexible semiparametric estimators of pairwise bivariate survivor functions at specified covariate histories, as well as semiparametric estimators of cross ratio and concordance functions given covariates. The presentation also describes how these innovative methods may extend to handle issues of dependent censorship, missing and mismeasured covariates, and joint modeling of failure times and covariates, setting the stage for additional theoretical and applied developments. This book extends and continues the style of the classic Statistical Analysis of Failure Time Data by Kalbfleisch and Prentice. Ross L. Prentice is Professor of Biostatistics at the Fred Hutchinson Cancer Research Center and University of Washington in Seattle, Washington. He is the recipient of COPSS Presidents and Fisher awards, the AACR Epidemiology/Prevention and Team Science awards, and is a member of the National Academy of Medicine. Shanshan Zhao is a Principal Investigator at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina.

This book collects and unifies statistical models and methods that have been proposed for analyzing interval-censored failure time data. It provides the first comprehensive coverage of the topic of interval-censored data and complements the books on right-censored data. The focus of the book is on nonparametric and semiparametric inferences, but it also describes parametric and imputation approaches. This book provides an up-to-date reference for people who are conducting research on the analysis of interval-censored failure time data as well as for those who need to analyze interval-censored data to answer substantive questions.

Contains additional discussion and examples on left truncationas well as material on more general censoring and truncationpatterns. Introduces the martingale and counting process formulation swillbe in a new chapter. Develops multivariate failure time data in a separate chapterand extends the material on Markov and semi Markovformulations. Presents new examples and applications of data analysis.

This book presents new and powerful advanced statistical methods that have been used in modern medicine, drug development, and epidemiology. Some of these methods were initially developed for tackling medical problems. All 29 chapters are self-contained. Each chapter represents the new development and future research topics for a medical or statistical branch. For the benefit of readers with different statistical background, each chapter follows a similar style: the explanation of medical challenges, statistical ideas and strategies, statistical methods and techniques, mathematical remarks and background and reference. All chapters are written by experts of the respective topics.

CSISE2011 is an integrated conference concentrating its focus upon Computer Science,Intelligent System and Environment. In the proceeding, you can learn much more knowledge about Computer Science, Intelligent System and Environment of researchers all around the world. The international conference will provide a forum for engineers, scientist, teachers and all researchers to discuss their latest research achievements and their future research plan. The main role of the proceeding is to be used as an exchange pillar for researchers who are working in the mentioned field. In order to meet high standard of Springer ́s Advances in Intelligent and Soft Computing ,the organization committee has made their efforts to do the following things. Firstly, poor quality paper has been refused after reviewing course by anonymous referee experts. Secondly, periodically review meetings have been held around the reviewers about five times for exchanging reviewing suggestions. Finally, the conference organization had several preliminary sessions before the conference. Through efforts of different people and departments, the conference will be successful and fruitful. We hope that you can get much more knowledges from our CSISE2011, and we also hope that you can give us good suggestions to improve our work in the future.

Survival data or more general time-to-event data occur in many areas, including medicine, biology, engineering, economics, and demography, but previously standard methods have requested that all time variables are univariate and independent. This book extends the field by allowing for multivariate times. As the field is rather new, the concepts and the possible types of data are described in detail. Four different approaches to the analysis of such data are presented from an applied point of view.

Multivariate Survival Analysis and Competing Risks introduces univariate survival analysis and extends it to the multivariate case. It covers competing risks and counting processes and provides many real-world examples, exercises, and R code. The text discusses survival data, survival distributions, frailty models, parametric methods, multivariate

Since 1945, "The Annual Deming Conference on Applied Statistics" has been an important event in the statistics profession. In Clinical Trial Biostatistics and Biopharmaceutical Applications, prominent speakers from past Deming conferences present novel biostatistical methodologies in clinical trials as well as up-to-date biostatistical applications

A practical guide for multivariate statistical techniques-- nowupdated and revised In recent years, innovations in computer technology and statisticalmethodologies have dramatically altered the landscape ofmultivariate data analysis. This new edition of Methods forStatistical Data Analysis of Multivariate Observations explorescurrent multivariate concepts and techniques while retaining thesame practical focus of its predecessor. It integrates methods anddata-based interpretations relevant to multivariate analysis in away that addresses real-world problems arising in many areas ofinterest. Greatly revised and updated, this Second Edition provides helpfulexamples, graphical orientation, numerous illustrations, and anappendix detailing statistical software, including the S (or Splus)and SAS systems. It also offers * An expanded chapter on cluster analysis that covers advances inpattern recognition * New sections on inputs to clustering algorithms and aids forinterpreting the results of cluster analysis * An exploration of some new techniques of summarization andexposure * New graphical methods for assessing the separations among theeigenvalues of a correlation matrix and for comparing sets ofeigenvectors * Knowledge gained from advances in robust estimation anddistributional models that are slightly broader than themultivariate normal This Second Edition is invaluable for graduate students, appliedstatisticians, engineers, and scientists wishing to usemultivariate techniques in a variety of disciplines.