Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Traumatic brain injury (TBI) remains one of healthcare's most significant challenges and policy making. TBI could not only lead to long-term functional impairment but also a decrease in quality of life. Lowering the mortality risk and benefitting survivors' living quality remains the target of neurotrauma studies globally. With the advent of novel TBI-related clinical and basic research approaches, diagnostics, therapeutics research, and novel and multidisciplinary methods have emerged. Despite promising progress, no completely effective treatment prevents or minimizes TBI and its related neurological and psychiatric sequelae. Understanding the mechanisms underlying the pathophysiology, treatment progress, and clinically based translational and engineering research on TBI may pave the way for potential treatment targets, diagnostic markers, and preventive methods that ultimately lead to efficacious therapeutic strategies. This Research Topic aims to disseminate high-quality TBI and related research, especially for the compositive and in-depth study in integration, translation, and multidisciplinary approaches in TBI research, including new technology and research methods in clinical neurology, new findings in neuroendocrinology, neuropathology and new development in neuropharmacology, neurophysiology. This Research Topic is focused on novel developments, current challenges, future perspectives, and especially interdisciplinary research in the field of TBI.

The third edition of Manual of Traumatic Brain Injury offers a thorough revision of the popular evidence-based guide to understanding and managing all levels of traumatic brain injury. Comprehensive in scope and concise in format, this reference describes the spectrum of injury from mild to severe and the continuum of care from initial injury to management of chronic sequelae. Chapters are designed with a practical clinical focus for targeted retrieval of content by topic area and for self-review. The text is organized into five sections. Part I addresses fundamental concepts necessary for understanding the underpinning of clinical decision-making. Part II is dedicated to mild TBI, including sport-related concussion, with chapters covering topics from natural history to associated somatic disorders, post-concussion syndrome, and PTSD. Part III covers moderate to severe TBI and details prehospital emergency and ICU care, rehabilitation, treatment of related conditions, and postinjury outcomes. Part IV focuses on TBI-related complications, including posttraumatic seizures, spasticity, behavioral and sleep disturbances, and chronic traumatic encephalopathy (CTE). Part V reviews special considerations in selected populations such as pediatric TBI and TBI in the military, as well as medicolegal and ethical considerations in TBI, complementary and alternative medicine, and return to work considerations. Each chapter includes boxed Key Points which underscore major clinical takeaways, Study Questions to facilitate self-assessment and further emphasize core chapter content, and an Additional Reading list for a deeper dive into chapter concepts. Significant updates incorporating recent advancements in the field, combined with the clinical acumen of its experienced contributors, make this third edition the essential manual for healthcare professionals caring for individuals with traumatic brain injury. Key Features: Succinct format encourages targeted access to key clinical information Completely revised and updated third edition reflects current state of the art advancements Added content areas such as a new chapter dedicated to substance abuse and TBI expand the scope of material addressed Newly added multiple choice Study Questions in each chapter facilitate self-assessment of mastery of chapter material

In October 2011, the Institute of Medicine (IOM) released the report Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence, assessing the published evidence for the effectiveness of using cognitive rehabilitation therapy (CRT) to treat people with traumatic brain injury (TBI). TBI has gained increasing attention in the past 15 years because of its status as the signature wound of American military conflicts in Iraq and Afghanistan. Growing numbers of U.S. service members are suffering traumatic brain injuries and are surviving them, given that (a) the majority of traumatic brain injuries are mild and (b) lifesaving measures for more severe injuries have significantly improved. People with any level of injury can require ongoing health care in their recovery, helping them to regain (or compensate for) their losses of function and supporting their full integration into their social structure and an improved quality of life. One form of treatment for TBI is CRT, a systematic, goal-oriented approach to helping patients overcome cognitive impairments. The Department of Defense (DoD) asked the IOM to evaluate CRT for traumatic brain injury in order to guide the DoD's use and coverage in the Military Health System. Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence was the IOM's resulting study of the evidence. The report's conclusions revolved around the fact that there is little continuity among research studies of the effectiveness of different types of CRT, and there exist only small amounts of evidence (or, in many cases, none) demonstrating the effectiveness of using CRT to treat TBI-although the evidence that does exist generally indicates that CRT interventions have some effectiveness. The workshop brought together experts in health services administration, research, and clinical practice from the civilian and military arenas in order to discuss the barriers for evaluating the effectiveness of CRT care and for identifying suggested taxonomy, terminology, timing, and ways forward for CRT researchers. The workshop consisted of individuals and was not intended to constitute a comprehensive group. Select decision makers in the Military Health System and Veterans Affairs (VA) and researchers were invited to participate. The workshop was designed to spur thinking about (1) the types of research necessary to move the field forward toward evidence-based clinical guidelines, (2) what the translational pipeline looks like and what its current deficiencies are, and (3) considerations that decision makers may choose to use as they decide what research they will support and decide how they will balance the urgency of the need with the level of evidence for CRT interventions. Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Model Study Protocols and Frameworks to Advance the State of the Science summarizes the happenings of the workshop.

This comprehensively updated second edition features major revisions, 24 new chapters and more than 40 new authors, reflecting both the advances and key challenges within the field. Offering a systematic guide to the management of children and adults with severe traumatic brain injury throughout the entire chain of care, it includes evidence-based recommendations for each diagnostic and therapeutic measure, together with tips, tricks and pitfalls. The authors are all highly experienced clinicians and researchers who work with neurotrauma patients on a daily basis, and the editors represent the Scandinavian Neurotrauma Committee. The book helps professionals provide more systematic and higher-quality care in prehospital settings, primary hospitals, neurosurgical departments, neurointensive care units, and rehabilitation facilities. It is intended for all healthcare personnel involved in the multidisciplinary management of patients with head injuries, especially those in emergency care, neurosurgery, anesthesiology, radiology, and rehabilitation.

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 8th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW chapter on obesity and nutritional disorders, along with expanded coverage of rare diseases and epigenetics. It's the most comprehensive and authoritative pathophysiology text available! - The most comprehensive and authoritative pathophysiology text on the market provides unparalleled coverage of Pathophysiology content. - Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes — more than in any other pathophysiology text. - Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. - Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. - Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. - Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes. - Additional What's New boxes highlight the most current research and clinical development. - Nutrition and Disease boxes explain the link between concepts of health promotion and disease. - Chapter summary reviews provide concise synopses of the main points of each chapter. - NEW! Chapter on obesity and nutritional disorders thoroughly covers these growing global concerns. - NEW! Added coverage of rare diseases and epigenetics further explore genetic disease traits. - NEW! Over 50 new or heavily revised illustrations visually highlight pathophysiology concepts. - NEW! More than 30 new 3D animations on Evolve bring difficult concepts to life for a new perspective on disease processes.

Brain-Computer Interfacing, Volume 168, not only gives readers a clear understanding of what BCI science is currently offering, but also describes future expectations for restoring lost brain function in patients. In-depth technological chapters are aimed at those interested in BCI technologies and the nature of brain signals, while more comprehensive summaries are provided in the more applied chapters. Readers will be able to grasp BCI concepts, understand what needs the technologies can meet, and provide an informed opinion on BCI science. - Explores how many different causes of disability have similar functional consequences (loss of mobility, communication etc.) - Addresses how BCI can be of use - Presents a multidisciplinary review of BCI technologies and the opportunities they provide for people in need of a new kind of prosthetic - Offers a comprehensive, multidisciplinary review of BCI for researchers in neuroscience and traumatic brain injury that is also ideal for clinicians in neurology and neurosurgery

Describes multidisciplinary, integrative, and translational approaches to research and practice in pediatric traumatic brain injury.

This book covers the latest developments in the understanding and treatment of traumatic brain injury. Various world experts authored the chapters that comprise a wealth of updated information on intracranial pressure; monitoring and diagnostic methods; neuroinflammatory responses in traumatic brain injury; cerebral palsy and Covid-19–related brain disorder; pathogenesis and prevention of fetal, neonatal, infant, and child brain injury; hyperbaric oxygenation treatment; the engineering and modeling of head injury; systematic review on early-tracheostomy; intracranial aneurysm in tuberous sclerosis complex; and the neurobehavioral and cognitive aspects of brain injury. With these complex topics, every clinician, scientist, and researcher will find this book invaluable in understanding the latest improvements and advances in the diagnosis and treatment of traumatic brain injury.