Translational Sports Medicine covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. This title is an indispensable tool in grant writing and funding efforts with its practical, straightforward approach that will help aspiring investigators navigate challenging considerations in study design and implementation. It provides valuable discussions of the critical appraisal of published studies in translational sports medicine, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or sports medicine clinician who has ever had a good clinical idea but not the knowledge of how to test it. Readers will come to fully understand important concepts, including case-control study, prospective cohort study, randomized trial and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in translational sports medicine, and know what is needed in collaboration. - Focuses on the principles of evidence-based medicine and applies these principles to translational investigations within sports medicine - Details discussions of the critical appraisal of published studies in translational sports medicine, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care - Written by experts in the sports medicine field

Alpine skiing or downhill skiing is defined by six disciplines: Downhill, Super G, Giant Slalom, Slalom, Parallel, and Combined that test the athletes’ technical abilities and speed. It has long been a popular sport with many national and international championships and is a mainstay of the Winter Olympic Games. The Science of Alpine Ski Racing is the first book to discuss the science, coaching, research, and training of elite to recreational alpine ski racers for optimal performance. This book brings together the complex physiological, biomechanical, and technical components of the sport in a practical manner with which coaches and researchers alike can adopt to elicit better performance outcomes for athletes. Literature of this kind has never been formally researched and published specifically for the sport of alpine ski racing making it both unique and a cornerstone to the discipline. Backed by cutting-edge research, the book provides practical guidance on preparing athletes for high performance and understanding the core tenets of sports science underpinning it striking a balance between the complex theoretical and practical components coaches and athletes must prepare for in alpine ski racing. Accessibly written and featuring contributions from world-leading experts, The Science of Alpine Ski Racing covers key topics of health, training, and high performance in the sport and will be vital reading for youth coaches, professional ski instructors, strength and conditioning coaches, and sports science staff associated with winter sports programs as well as applied researchers looking for a model to apply to other sports. James (Jimmy) Pritchard is a human performance specialist/sports scientist who has trained and consulted athletes at the Olympic, NHL, NFL, and Division I collegiate level. Specific to alpine ski racing, he served as the Director of Strength and Conditioning for Ski and Snowboard Club Vail in Vail, Colorado where he helped prepare a long list of US Ski Team athletes including Alice McKennis, Mikaela Shiffrin, and Tess Johnson. He is a certified strength and conditioning specialist (CSCS) as well as registered strength and conditioning coach (RSCC) through the NSCA working with athletes and human performance program managers on a regular basis to find optimal human performance solutions. James has presented at conferences around the United States discussing long term athlete development, written over 150 articles for several media outlets, has been published in the NSCA’s Strength and Conditioning Journal, and taught courses about strength and conditioning at Colorado Mountain College. James holds a BSc in Exercise Science from Colorado Mesa University and MSc degree in Exercise Science from Edith Cowan University. Jim Taylor, PhD, Psychology, is an internationally recognized authority on the psychology of sport and parenting. He has consulted with athletes, coaches, and parents in tennis, skiing, cycling, triathlon, track and field, swimming, football, golf, baseball, fencing, and many other sports for more than 30 years. Dr. Taylor is the author of 17 books and the editor of 4 textbooks on sport psychology. He is also a former world-ranked alpine ski racer, second-degree black belt in karate, marathon runner, and Ironman triathlete.

Translational Sports Medicine covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. This title is an indispensable tool in grant writing and funding efforts with its practical, straightforward approach that will help aspiring investigators navigate challenging considerations in study design and implementation. It provides valuable discussions of the critical appraisal of published studies in translational sports medicine, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or sports medicine clinician who has ever had a good clinical idea but not the knowledge of how to test it. Readers will come to fully understand important concepts, including case-control study, prospective cohort study, randomized trial and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in translational sports medicine, and know what is needed in collaboration.

Effective fitness instruction and training programme design require an exercise specialist trainer to combine professional experience with strategies underpinned by scientific evidence. This book allows readers to develop their understanding of the scientific rationale behind important components of personal training, such as monitoring fitness and training programme design. Each chapter synthesizes the findings of cutting-edge scientific research to identify optimum training methods and dispel some myths that are prevalent in the fitness industry. The chapters within this new edition have been written by internationally renowned experts from several disciplines, including strength and conditioning, physiology, psychology, and nutrition. Contributions have also been made from esteemed academics who have conducted some of the scientific studies discussed within the book. The authors have interpreted and summarised the scientific evidence and produced evidence-based recommendations, allowing readers to explore the latest concepts and research findings and apply them in practice. The book includes several new chapters, such as evidenced based practice (EBP), and designing training programmes female clients. This second edition remains the essential text for fitness instructors, personal trainers and sport and exercise students. The book provides an invaluable resource for fitness courses, exercise science degree programmes and continued professional development for exercise professionals.

The book provides readers the informatics and data-driven models for the discovery of personalized excise prescriptions applied to different cases. Overdiagnosis or over-treatment often happened since the complex interaction among the lifestyle, genetic, and environmental factors. Sports and exercise are reported efficient to prevent or reduce the risk of diseases, but the interactions between sports/exercise and disease are personalized and complex. Translational informatics is a powerful paradigm and it promotes the transfer of big data, knowledge and models to the precision application of sports to prevent diseases. Sports and exercise may have different effects on diverse diseases including cancers, neurodegenerative disease, and cardiovascular diseases, etc. This book covers many modern informatics models such as ontologies, knowledge graphs, blockchain, participatory medicine, semantic artificial intelligence, big data modeling, and so on. It also describes the challenges for the sports and exercise medical data sharing and standardization, the privacy protection of data as well as the integration of data from genomic level to physiological phenotype level. This book will be helpful to the readers who are interesting in sports and exercise medicine, healthcare, big data modeling, artificial intelligence in medicine and healthcare.

Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine

This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 19th volume of a continuing series.

This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area. Engineering in Translational Medicine gives readers a comprehensive and in-depth overview of a broad array of related research areas, making this an excellent reference book for scientists and students both new to engineering/translational medicine and currently working in this area. The ability for engineering approaches to change biomedical research are increasing and having significant impact. Development of basic assays and their numerous applications are allowing for many new discoveries and should eventually impact human health. This book brings together many diverse yet related topics to give the reader a solid overview of many important areas that are not found together elsewhere. Dr. Weibo Cai has taken great care to select key research leaders of many sub-disciplines who have put together very detailed chapters that are easy to read yet highly rich in content. _______________ This book brings together many diverse yet related topics to give the reader a solid overview of many important areas that are not found together elsewhere. Dr. Weibo Cai has taken great care to select key research leaders of many sub-disciplines who have put together very detailed chapters that are easy to read yet highly rich in content. It is very exciting to see such a great set of chapters all together to allow one to have a key understanding of many different areas including cell, gene, protein, and nano engineering as well as the emerging field of theranostics. I am sure the readers will find this collection of important chapters helpful in their own research and understanding of how engineering has and will continue to play a critical role in biomedical research and clinical translation. Sanjiv Sam Gambhir M.D., Ph.D. Stanford University, USA Engineering in Translational Medicine is a landmark book bridging the fields of engineering and medicine with a focus on translational technologies and methods. In a single, well-coordinated volume, this book brings together contributions from a strong and international scientific cast, broadly covering the topics. The book captures the tremendous opportunities made possible by recent developments in bioengineering, and highlights the potential impact of these advances across a broad spectrum of pressing health care needs. The book can equally serve as a text for graduate level courses, a reference source, a book to be dipped into for pleasure by those working within the field, or a cover-to-cover read for those wanting a comprehensive, yet readable introduction to the current state of engineering advances and how they are impacting translational medicine. Simon R. Cherry, Ph.D. University of California, Davis, USA