The Operational guidance on adaptation and implementation of WHO’s Multisectoral Accountability Framework to end TB (MAF-TB) provides practical advice on key approaches and interventions needed to establish the MAF-TB at the national (and local) levels with concrete country examples, best practices and case studies under each suggested approach and interventions. It is intended for use by all stakeholders involved in their national TB response, including ministries of health and other relevant government ministries and bodies, national TB programmes (or their equivalents in ministries of health), other relevant national programmes, parliamentarians, the private sector, international organizations, nongovernmental and civil society organizations and TB-affected communities involved in planning, implementation, monitoring and evaluation and review of the TB response. The stakeholders involved may vary across countries depending on several factors, including the epidemiology and determinants of TB, the institutional arrangements for TB care and prevention and the degree of devolution of the political and health governance system.