Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics, Volume One, Discovery and Technologies discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancer types. This first volume in the series focuses on techniques and approaches recently developed to assist in the decision of which biomarker to use for specific conditions. Topics covered include circulating tumor cells and circulating tumor DNA, exomes, tumor microenvironment, gene editing, artificial intelligence and robotics. In addition, the book discusses the development and applications of organoids and precision medicine.This book will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research. Provides up-to-date information on current molecular biomarkers research for cancer Presents basic research aspects and novel technologies applied in the discovery of new biomarkers Discusses several technologies, including artificial intelligence, robotics, data mining, gene editing, omics and their applicability for specific cancer types

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. - Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways - Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease - Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease - Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

The cancer research world is looking forward to bionanotechnology to find the best solutions for a complete cure from cancer, which is not possible with the current established treatment methods. The past decade of research on nano imaging and drug delivery in cancer has witnessed many interesting papers and reviews, but there has not been a concise resource that discusses all fields related to nano cancer research in diagnosis and drug delivery. This book fills this gap and presents the latest bionano research in cancer, focusing on nanodiagnostics and nanotherapy. The book is organized into two sections. The section on nanodiagnostics focuses on topics such as diagnostic methods in cancer-related therapy and use of radiolabeled nanoparticles, magnetic nanoparticles, acoustically reflective nanoparticles, X-ray computed tomography, and optical nanoprobes for diagnosis. The section on nanotherapy focuses on nanomaterials in chemotherapy, magnetic nanoparticles for hyperthermia against cancer, phototherapy, nanotechnology-mediated radiation therapy, nanoparticle-mediated small-RNA deliveries for molecular therapies, and theranostics. The book will serve as the gateway to enter the beautiful and elegant field of bionanoscience, which is considered the last hope for the fight against cancer and will be a highly useful resource for the students, researchers, teachers, and curious readers working in this field or related fields.

This practical and handy textbook offers a succinct yet comprehensive overview of the main challenges, issues and solutions in global health in relation to the UN’s Sustainable Development Goals (SDG) 2030 agenda. Subdivided into 11 parts, devoted each to a macro-topic, the book opens with an introduction to Global Health followed by an overview of the global burden of disease – from child and maternal health to communicable and non-communicable diseases. The authors further examine the social determinants of health, health systems’ features as well as innovations, governance and methods in Global Health. In consideration of the emerging discussions and ideas, and beyond the more traditional and essential elements of global health, the book also looks at the need to re-think the whole concept of global health and the importance of a “decolonized” approach that engages low and lower-middle countries fully. One entire part is then devoted to analyzing the major threats to the health of humanity such as climate change, the need for an ecological approach to health (including “One Health” approaches), and, ultimately, planetary health. Written by an international panel of more than 100 experts, this manual will be an excellent resource for students in a broad range of disciplines – from medicine and other scientific studies to economics, social science, anthropology and international relations. Pragmatic and reader-friendly, it will further be a valuable tool for policymakers, program implementers and those wishing to build knowledge on the meaning, principles and practices of global health.

This framework document is a “how-to” guide for policy-makers and programme managers to effectively implement the CureAll pillars and enablers. It provides justification for action, posits priority interventions and proposes a monitoring framework. Key components needed to establish, scale up and sustain a well-functioning national childhood cancer programme are explained.The scope of this framework document is centrally defined by the programmes, services and policies that support children with cancer in the context of the health system. For the Initiative, children are defined as those aged 19 years or younger. Childhood cancer care requires cross-cutting strategies, such as workforce training, that often have overlap with broader child health and/or cancer control programmes. These synergies are highlighted and considered in scope for the Initiative and for an integrated response in childhood cancer control. The primary audience for this framework document are policy-makers, cancer control programme managers and hospital managers at the country level. Additional key stakeholders may also find the information in this guide beneficial, including clinicians, parent groups, civil society, academia and interested parties in the private sector. The primary audience for this framework document are policy-makers, cancer control programme managers and hospital managers at the country level. Additional key stakeholders may also find the information in this guide beneficial, including clinicians, parent groups, civil society, academia and interested parties in the private sector.