Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more. - Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline - Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering - Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control - Examines the diverse research being conducted in the study of the biology of aging

Neurovascular disorders are a group of pathological conditions resulting from the neurovascular injury. Neurovascular disorders include cerebral ischemia, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, glioma, carotid disease, cerebral small vessel disease, and vascular dementia, among others. Although we have accumulated more understanding of both the genetic links and the basic mechanisms behind the pathophysiology of neurovascular diseases over the years, the exact mechanisms are still unclear. Therefore, there is an urgency to identify important therapeutic targets.

The World Health Organization defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”, and its constitution also asserts that health for all people is “dependent on the fullest co-operation of individuals and States”. The ongoing pandemic has highlighted the power of both healthy and unhealthy information, so while healthcare and public health services have depended upon timely and accurate data and continually updated knowledge, social media has shown how unhealthy misinformation can be spread and amplified, reinforcing existing prejudices, conspiracy theories and political biases. This book presents the proceedings of MedInfo 2021, the 18th World Congress of Medical and Health Informatics, held as a virtual event from 2-4 October 2021, with pre-recorded presentations for all accepted submissions. The theme of the conference was One World, One Health – Global Partnership for Digital Innovation and submissions were requested under 5 themes: information and knowledge management; quality, safety and outcomes; health data science; human, organizational and social aspects; and global health informatics. The Programme Committee received 352 submissions from 41 countries across all IMIA regions, and 147 full papers, 60 student papers and 79 posters were accepted for presentation after review and are included in these proceedings. Providing an overview of current work in the field over a wide range of disciplines, the book will be of interest to all those whose work involves some aspect of medical or health informatics.

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-versus-splitting tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases. Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more