Bryce Weir is a high-profile, respected neurologist. Dr. Macdonald is a colleague of Dr. Weir's and is a "rising star" in the field of neurology.This book is the first to cover all aspects of cerebral vasospasm in depth. It takes the reader from the first descriptions of this puzzling and deadly phenomenon to the latest laboratory evidence explaining its pathophysiology. Packed with clinical pearls, it is a must for neurosurgeons, interventional radiologists, neurologists, and neuropathologists.Key Features* Examines the current understanding of vascular smooth muscle physiology* Provides in-depth overviews of symptoms and treatments* Written by acknowledged experts on the subject* Vividly illustrated with beautiful photographs and diagrams* Cites over 4,000 key papers on vasospasms* Presents key data in an easy-to-use format

This comprehensive volume is the current final word on the subject. It contains more than 90 papers, giving a summary of clinical and basic studies on cerebral vasospasm. It includes reviews by leading researchers in the field. Several new subjects are proposed for future research that will not only promote research from neurosurgery and neurology but also from other interconnecting fields of emergency medicine, electrophysiology, molecular biology, and vascular biology.

Cerebral vasospasm remains a major clinical problem in patients with subarachnoid hemorrhage. Neuroprotection with calcium antagonists, hemodynamic therapy and interventional angioplasty have an established role in the management of this disease, but an effective single drug for prevention or treatment of the vasospasm is still lacking. This book contains selected contributions to the 7th International Conference on Cerebral Vasospasm held in Interlaken, Switzerland, in June 2000. Part I of the book concentrates on basic science and experimental vasospasm. The molecular biology of vasospasm, the role of endothelin and nitric oxide as well as the potential of gene therapy are presented. Part II concentrates on the diagnosis and therapy of clinical vasospasm. New diagnostic tools are presented, including diffusion and perfusion-weighted MRI, MR spectroscopy and microdialysis with metabolic monitoring. Leaders in the field discuss the current indications and results of endovascular treatment of cerebral vasospasm. The latter chapters are devoted to the treatment of clinical vasospasm with new drugs and to the prevention and treatment of ischemic deficits with neuroprotective drugs and hemodynamic therapy. The book provides the state-of-the-art in the major subjects of the molecular biology of vasoconstriction and experimental vasospasm as well as the diagnosis and treatment of clinical vasospasm.

The book contains 48 articles presented at the 11th International Conference on Cerebral Vasospasm held in Cincinnati, Ohio, USA, in July 2011. This collection of papers represents a cross-section of the enormous progress that has been made towards a thorough understanding and effective treatment of neurovascular events following aneurysmal subarachnoid hemorrhage, including cerebral vasospasm. It is of interest to clinicians who wish to apply state-of-the-art knowledge to their management of this devastating condition and to basic scientists wishing to expand their understanding of cerebrovascular and neural pathophysiology related to subarachnoid hemorrhage.

More than 40 articles provide an extensive coverage of clinical and basic science advances over the last three years of research on subarachnoid hemorrhage-induced brain injuries. Early brain injury, the new frontier of subarachnoid hemorrhage research, which may be a key contributor to the high mortality and morbidity, promotes collaborative efforts from neurosurgery, neurology, neuro-ICU into other interrelated fields and basic neurosciences. For the first time, subarachnoid hemorrhage research is almost equally divided by early brain injury and cerebral vasospasm, mechanistic investigations and therapeutic approaches, demonstrating a translational feature of the future direction.

Vasospasm is the narrowing of the arteries in the brain following an aneurysm. It is one of the leading causes of death after a brain aneurysm. Contemporary Understanding and Management of Cerebral Vasospasm covers topics from recent advances in molecular mechanisms contributing to cerebral vasospasm, to practical microsurgical and endovascular treatment. Other topics include, the role of MRI in subarachnoid haemorrhage-related vasospasm and computed tomography, CT perfusion angiography correlated with digital subtracted angiography, and transcranial Doppler ultrasound imaging for detecting intracerebral arterial vasospasm. Contemporary Understanding and Management of Cerebral Vasospasm is essential reading for practitioners, including neurosurgeons, vascular specialists and neuroradiologists. Key Features Focuses on the latest advances in management of cerebral vasospasm 38 illustrations and images enhance explanations of latest developments in the field Edited by team of renowned US experts from Yale-New Haven Hospital, Connecticut