Sickle cell anemia is an inherited disorder of the globin chains that causes hemolysis and chronic organ damage. Sickle cell anemia is the most common form of sickle cell disease (SCD), with a lifelong affliction of hemolytic anemia requiring blood transfusions, pain crises, and organ damage. Since the first description of the irregular sickle-shaped red blood cells (RBCs) more than 100 years ago, our understanding of the disease has evolved tremendously. Recent advances in the field, more so within the last three decades, have alleviated symptoms for countless patients, especially in high-income countries. Although there is evidence of several important therapies in the pipeline, greater investment in research is needed into both of these therapies and the dissemination of effective care to the affected population, especially because of historical mistrust. In this book, we present an overview of sickle cell disease, pathogenesis, clinical presentation, complications, and recent treatment modalities and prospective research that will enable the reader to get a better understanding of this hot topic.

Clinical Cardiology: Current Practice Guidelines Updated Edition is an essential tool for the busy clinician, offering succinct yet detailed access to the most recent trial and guideline data supporting practice and patient management in cardiology. ESC and ACC/AHA guidelines are continually updated and often overlap in their advice, making it difficult for the cardiologist to obtain a clear picture of the right way to diagnose and treat disease according to the latest evidence base. Written by leading authorities in the field, this book, together with its regularly-updated online version, provides a unique solution. The authors have scrutinized all available guidelines and research from both ACC/AHA and ESC on every clinical issue. The result is a rigorous examination of the implications of published guidance, illustrated by more than 600 easy-to-follow tables and 200 full-colour images, which reinforce key points and clarify difficult concepts. 87 comprehensive chapters explore the definition, epidemiology, pathophysiology, diagnosis and management of cardiac disease. Two new chapters examine the univentricular heart and venous thrombembolism. Each chapter encompasses the latest published research, followed by discussions of possible presentations and investigations, offering detailed insights for clinicians into best practice for diagnosis and treatment. Providing at-a-glance access to the best guidance in cardiology, this book offers a diagnosis and management toolkit which no practising cardiologist can afford to be without.

This textbook provides a brief review of pediatric medicine practice. This book covers the diseases and disorders commonly seen in routine practice. The chapters cover pediatric disorders such as obesity, gastroesophageal reflux, asthma, bronchiolitis, pneumonia, allergy, sinusitis, diabetes, thyroid disorder, epistaxis, otitis media, hearing loss, laryngomalacia, obstructive sleep apnea, central sleep apnea, laryngomalacia, stridor, tonsillitis, haemophilia, autism, and anxiety. Key features of this textbook include: - Reader friendly format which explains etiology, pathophysiology, and disease management - 21 chapters covering common pediatric disorders encountered by medical professionals - Contributions by several experts in pediatric subspecialties This textbook is a suitable reference for medical students, interns, residents, and specialists including pediatricians, family medicine practitioners, otolaryngologists as well as subspecialists such as pediatric cardiologists, pulmonologists, endocrinologists, otolaryngologists and allergists.

This is an essential guide to the data, basic science, outcome studies and decision-making processes involved in blood and marrow stem cell transplantation. Organized according to disease types and procedures, it contains more than 100 tables, figures and algorithms that reflect up-to-date research and give guidance on the choices between different types of chemotherapy, autologous vs. allogeneic transplantation, peripheral blood vs. bone marrow stem cells, and standard vs. experimental treatments. This new edition summarizes the research of the last four years and gives mature data for all established indications, such as acute myeloid leukemia, myelodysplastic syndrome and Hodgkin and non-Hodgkin lymphomas. New chapters discuss global trends in stem cell transplantation, cellular therapies including donor lymphocytes, and pediatric neurologic and metabolic disorders. With an expanded complications section, links to electronic databases and discussion of new drugs and alternative stem cell sources, this text belongs in every transplant unit.

The standard-setting clinical electroencephalography textbook has been rewritten for the next decade of EEG technicians and resident and practicing neurologists. This Third Edition reflects the transition of the field to an all-digital environment, with fundamental changes in data recording, analysis, and interpretation. Drs. Ebersole and Pedley are outstanding educators with extensive experience in editing two of the leading journals--Journal of Clinical Neurophysiology and Epilepsia, respectively. In this volume, Ebersole and Pedley cover the full range of applications of EEG and evoked potentials in contemporary clinical practice. The book explains the most advanced instrumentation and techniques and their use in evaluating various disorders. More than 600 illustrations depict both normal and abnormal findings.

Readable, concise, and data-driven, Current Practice of Clinical Electroencephalography, 5th Edition, delivers a comprehensive overview of the dynamic field of EEG. Dr. Aatif M. Husain leads a team of internationally recognized authors who provide updates on established areas of clinical EEG, discuss newly evolving areas, and explain neurophysiological basis of pathology to encourage understanding rather than simply pattern recognition. Now in full color throughout, it’s a must-have resource for residents, neurologists, clinical neurophysiologists, epilepsy specialists, electroneurodiagnostic technologists and practicing electroencephalographers, as well as students, trainees, and researchers—anyone who desires to stay up to date and use EEG to its fullest potential.

Sickle cell disease (SCD) is a genetic condition that affects approximately 100,000 people in the United States and millions more globally. Individuals with SCD endure the psychological and physiological toll of repetitive pain as well as side effects from the pain treatments they undergo. Some adults with SCD report reluctance to use health care services, unless as a last resort, due to the racism and discrimination they face in the health care system. Additionally, many aspects of SCD are inadequately studied, understood, and addressed. Addressing Sickle Cell Disease examines the epidemiology, health outcomes, genetic implications, and societal factors associated with SCD and sickle cell trait (SCT). This report explores the current guidelines and best practices for the care of patients with SCD and recommends priorities for programs, policies, and research. It also discusses limitations and opportunities for developing national SCD patient registries and surveillance systems, barriers in the healthcare sector associated with SCD and SCT, and the role of patient advocacy and community engagement groups.

Issues in Ophthalmology and Optometry Research and Practice: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Orthoptics. The editors have built Issues in Ophthalmology and Optometry Research and Practice: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Orthoptics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Ophthalmology and Optometry Research and Practice: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.