Few advances in MR imaging have had the impact degenerative neurologic disorders, white matter d- that dif usion-weighted (DW) imaging has had in the eases, toxic/metabolic disorders, and tumors. As one evaluation of brain. From the time of the early de- can easily see from the table of contents, the authors scriptions by LeBihan and colleagues of the ability have systematically covered all major areas of neu- to image and measure the micromovement of water radiology. T is will allow cross-referencing to pr- molecules in the brain to the present time, dif usion lematic cases which one may encounter. Additionally, imaging and its derivatives have made an impact in knowledge of what represents a normal adult brain the evaluation of multiple disease processes, primar- and a normal developing brain along with an exp- ily in ischemia, but also in other conditions of the nation of artifacts seen in DW imaging makes this a brain. In most medical centers dif usion imaging is valuable book. It is noteworthy that the authors have no longer considered a sequence to be used in spe- chosen to abundantly illustrate the clinical material, cial circumstances, but rather it is employed as part drawing on pathologic correlations in a number of of routine MR imaging of the brain. Because the in- areas.

Diffusion-weighted MR imaging is widely accepted as a means to identify stroke, thus enabling rapid and effective treatment. Over the past four years, these expert authors have presented over 30 exhibits and scientific reports on diffusion-weighted imaging at the RSNA and the American Society of Neuroradiology (ASNR), and more than 10 of these presentations have been recognized by specific awards. Diffusion-Weighted MR Imaging of the Brain’s chapters range from basic principles to interpretation of diffusion-weighted MR imaging and specific disease. This is a valuable reference for radiologists, neurologists, neurosurgeons as well as residents, fellows, radiology technologists.

It is a great privilege to introduce this book devoted to the current and future roles in research and clinical practice of another exciting new development in MRI: Diffusi- weighted MR imaging. This new, quick and non-invasive technique, which requires no contrast media or i- izing radiation, offers great potential for the detection and characterization of disease in the body as well as for the assessment of tumour response to therapy. Indeed, whereas DW-MRI is already ? rmly established for the study of the brain, progress in MR techn- ogy has only recently enabled its successful application in the body. Although the main focus of this book is on the role of DW-MRI in patients with malignant tumours, n- oncological emerging applications in other conditions are also discussed. The editors of this volume, Dr. D. M. Koh and Prof. H. Thoeny, are internationally well known for their pioneering work in the ? eld and their original contributions to the l- erature on DW-MRI of the body. I am very much indebted to them for the enthusiasm and engagement with which they prepared and edited this splendid volume in a record short time for our series Medical Radiology – Diagnostic section.

This richly illustrated book, now in an updated and extended third edition, systematically covers the use of diffusion-weighted (DW) MR imaging in all major areas of neuroradiology, including imaging of the head and neck and the spine as well as the brain. The authors guide the reader from the basic principles of DW imaging through to the use of cutting-edge diffusion sequences such as diffusion tensor (DTI) and kurtosis (DKI), fiber tractography, high b value, intravoxel incoherent motion (IVIM), neurite orientation dispersion and density imaging (NODDI), and oscillating gradient spin echo (OGSE). Pathology, pathophysiology, and patient management and treatment are all thoroughly discussed. Since the early descriptions by LeBihan and colleagues of the ability to image and measure the micromovement of water molecules in the brain, diffusion imaging and its derivatives have contributed ever more significantly to the evaluation of multiple disease processes. In comprehensively describing the state of the art in the field, this book will be of high value not only for those who deal routinely with neuro-MR imaging but also for readers who wish to establish a sound basis for understanding diffusion images in the hope of extending these principles into more exotic areas of neuroimaging.

Magnetic Resonance Imaging (MRI) is a unique technique that provides tissue-specific contrast non-invasively. However, even at ultra-high field, resolution remains on the millimeter scale, far above cellular microstructure. Taking the fact that diffusion of nuclear spins in magnetic field gradients results in a characteristic signal loss, MRI can be sensitized to water-diffusion (DW-MRI) to recover microstructural information indirectly. Diffusion-Weighted MR Spectroscopy (DW-MRS) goes one step further by not measuring the diffusion of tissue water but of cell-type specific metabolites. Given that, both techniques can provide complementary information: DW-MRI on water diffusion with high spatial resolution but without cellular specificity, and DW-MRS on cell-type specific metabolite diffusion but with a limited spatial resolution (single-volume) and at a lower signal-to-noise ratio (SNR). To meet the needs of sophisticated tissue and cell modeling strategies to derive quantitative microstructural measures both techniques have to be sensitized to specific length scales and structural features. This can only be achieved by constant development in sequence design, diffusion-encoding, tissue modeling, data processing, and technical equipment. This research topic aims to attract contributions from all these fields targeting DW-MRI and DW-MRS improvement to accomplish two fundamental goals: (1) providing unique intra-voxel distributions of a set of diffusion parameters instead of an averaged value; allowing the identification of multiple compartments and tissue microstructure, (2) enabling higher accuracy and precision in derived quantitative values. Acquisitional, computational, and pulse design technological breakthroughs have positioned DW-MRI and DW-MRS as powerful emerging modalities for studying biological media, from muscle to the central nervous system, exhibiting extraordinary sensitivity and specificity in differentiating normal from pathologic cell-level processes and microstructural alterations. We welcome studies and manuscripts covering all aspects of DW-MRI, DW-MRS, tissue/cell modeling, study protocol design, or technical innovation: from theoretical studies focusing on the mathematical and physiological background of tissue microstructural modeling, to technical developments, to phantom studies, to novel acquisition and sampling strategies, to improved diffusion encoding techniques, to clinical studies. We are encouraging the submission of the following types of manuscripts: original research and brief research reports, methods, protocols and study protocols, review and mini review, perspective, hypothesis and theory, technology and code, clinical trial, case report, classification, and data report. Topics for submitted papers can be in one of the following general categories: - Development of processing methods, instrumentation, or experimental design of DW-MRI and DW-MRS. - Introduction of new theoretical or simulation models to DW-MRI or DW-MRS. - In vivo (human and animal), in vitro, in silico, phantom, and ex vivo studies are welcome.

Continuous improvement in MRI technology in recent years has led to the application of diffusion-weighted MR imaging in organ systems outside the brain. Extra-Cranial Applications of Diffusion-Weighted MRI provides an extensive review of current and future applications of this imaging modality by world-renowned experts. Organized by organ system, each chapter is highly illustrated, offering a balance of protocols, illustrations and principles of image interpretation. An initial chapter provides an overview of relevant physics and other technical details, followed by detailed chapters on all major body systems including liver, kidney, prostate, breast and spine. A final chapter discusses assessment of therapy response. Written and edited by leading DW-MRI experts worldwide, Extra-Cranial Applications of Diffusion-Weighted MRI is an invaluable resource for radiology trainees, practising radiologists and for researchers in a wide variety of disciplines.

Practical Differential Diagnosis in CT and MRI is a one-stop resource for the differential diagnosis of common and rare radiologic findings and conditions in all regions of the body. For each finding and diagnosis, the book provides a complete list of differential diagnoses as well as the features that will help the clinician differentiate diseases with similar findings. Highlights: Concise descriptions aid the identification of key radiologic signs Easy-to-use tables and bullet-point lists facilitate rapid review of important information about findings, differentiating features, and disease entities This pocket-sized book is ideal for residents preparing for board examinations as well as for radiologists in practice.

CD-ROM contains the text of Magnetic resonance imaging including over 270 images, zoom functions and searching capabilities.