Few advances in MR imaging have had the impact degenerative neurologic disorders, white matter d- that dif usion-weighted (DW) imaging has had in the eases, toxic/metabolic disorders, and tumors. As one evaluation of brain. From the time of the early de- can easily see from the table of contents, the authors scriptions by LeBihan and colleagues of the ability have systematically covered all major areas of neu- to image and measure the micromovement of water radiology. T is will allow cross-referencing to pr- molecules in the brain to the present time, dif usion lematic cases which one may encounter. Additionally, imaging and its derivatives have made an impact in knowledge of what represents a normal adult brain the evaluation of multiple disease processes, primar- and a normal developing brain along with an exp- ily in ischemia, but also in other conditions of the nation of artifacts seen in DW imaging makes this a brain. In most medical centers dif usion imaging is valuable book. It is noteworthy that the authors have no longer considered a sequence to be used in spe- chosen to abundantly illustrate the clinical material, cial circumstances, but rather it is employed as part drawing on pathologic correlations in a number of of routine MR imaging of the brain. Because the in- areas.

Diffusion-weighted MR imaging is widely accepted as a means to identify stroke, thus enabling rapid and effective treatment. Over the past four years, these expert authors have presented over 30 exhibits and scientific reports on diffusion-weighted imaging at the RSNA and the American Society of Neuroradiology (ASNR), and more than 10 of these presentations have been recognized by specific awards. Diffusion-Weighted MR Imaging of the Brain’s chapters range from basic principles to interpretation of diffusion-weighted MR imaging and specific disease. This is a valuable reference for radiologists, neurologists, neurosurgeons as well as residents, fellows, radiology technologists.

This richly illustrated book, now in an updated and extended third edition, systematically covers the use of diffusion-weighted (DW) MR imaging in all major areas of neuroradiology, including imaging of the head and neck and the spine as well as the brain. The authors guide the reader from the basic principles of DW imaging through to the use of cutting-edge diffusion sequences such as diffusion tensor (DTI) and kurtosis (DKI), fiber tractography, high b value, intravoxel incoherent motion (IVIM), neurite orientation dispersion and density imaging (NODDI), and oscillating gradient spin echo (OGSE). Pathology, pathophysiology, and patient management and treatment are all thoroughly discussed. Since the early descriptions by LeBihan and colleagues of the ability to image and measure the micromovement of water molecules in the brain, diffusion imaging and its derivatives have contributed ever more significantly to the evaluation of multiple disease processes. In comprehensively describing the state of the art in the field, this book will be of high value not only for those who deal routinely with neuro-MR imaging but also for readers who wish to establish a sound basis for understanding diffusion images in the hope of extending these principles into more exotic areas of neuroimaging.

It is a great privilege to introduce this book devoted to the current and future roles in research and clinical practice of another exciting new development in MRI: Diffusi- weighted MR imaging. This new, quick and non-invasive technique, which requires no contrast media or i- izing radiation, offers great potential for the detection and characterization of disease in the body as well as for the assessment of tumour response to therapy. Indeed, whereas DW-MRI is already ? rmly established for the study of the brain, progress in MR techn- ogy has only recently enabled its successful application in the body. Although the main focus of this book is on the role of DW-MRI in patients with malignant tumours, n- oncological emerging applications in other conditions are also discussed. The editors of this volume, Dr. D. M. Koh and Prof. H. Thoeny, are internationally well known for their pioneering work in the ? eld and their original contributions to the l- erature on DW-MRI of the body. I am very much indebted to them for the enthusiasm and engagement with which they prepared and edited this splendid volume in a record short time for our series Medical Radiology – Diagnostic section.

Magnetic Resonance Imaging (MRI) is a unique technique that provides tissue-specific contrast non-invasively. However, even at ultra-high field, resolution remains on the millimeter scale, far above cellular microstructure. Taking the fact that diffusion of nuclear spins in magnetic field gradients results in a characteristic signal loss, MRI can be sensitized to water-diffusion (DW-MRI) to recover microstructural information indirectly. Diffusion-Weighted MR Spectroscopy (DW-MRS) goes one step further by not measuring the diffusion of tissue water but of cell-type specific metabolites. Given that, both techniques can provide complementary information: DW-MRI on water diffusion with high spatial resolution but without cellular specificity, and DW-MRS on cell-type specific metabolite diffusion but with a limited spatial resolution (single-volume) and at a lower signal-to-noise ratio (SNR). To meet the needs of sophisticated tissue and cell modeling strategies to derive quantitative microstructural measures both techniques have to be sensitized to specific length scales and structural features. This can only be achieved by constant development in sequence design, diffusion-encoding, tissue modeling, data processing, and technical equipment. This research topic aims to attract contributions from all these fields targeting DW-MRI and DW-MRS improvement to accomplish two fundamental goals: (1) providing unique intra-voxel distributions of a set of diffusion parameters instead of an averaged value; allowing the identification of multiple compartments and tissue microstructure, (2) enabling higher accuracy and precision in derived quantitative values. Acquisitional, computational, and pulse design technological breakthroughs have positioned DW-MRI and DW-MRS as powerful emerging modalities for studying biological media, from muscle to the central nervous system, exhibiting extraordinary sensitivity and specificity in differentiating normal from pathologic cell-level processes and microstructural alterations. We welcome studies and manuscripts covering all aspects of DW-MRI, DW-MRS, tissue/cell modeling, study protocol design, or technical innovation: from theoretical studies focusing on the mathematical and physiological background of tissue microstructural modeling, to technical developments, to phantom studies, to novel acquisition and sampling strategies, to improved diffusion encoding techniques, to clinical studies. We are encouraging the submission of the following types of manuscripts: original research and brief research reports, methods, protocols and study protocols, review and mini review, perspective, hypothesis and theory, technology and code, clinical trial, case report, classification, and data report. Topics for submitted papers can be in one of the following general categories: - Development of processing methods, instrumentation, or experimental design of DW-MRI and DW-MRS. - Introduction of new theoretical or simulation models to DW-MRI or DW-MRS. - In vivo (human and animal), in vitro, in silico, phantom, and ex vivo studies are welcome.

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of editors and authors provide updated content, a significantly expanded video library, and hundreds of new video lectures that help you master new procedures, new technologies, and essential anatomic knowledge in neurosurgery. - Discusses current topics such as diffusion tensor imaging, brain and spine robotic surgery, augmented reality as an aid in neurosurgery, AI and big data in neurosurgery, and neuroimaging in stereotactic functional neurosurgery. - 55 new chapters provide cutting-edge information on Surgical Anatomy of the Spine, Precision Medicine in Neurosurgery, The Geriatric Patient, Neuroanesthesia During Pregnancy, Laser Interstitial Thermal Therapy for Epilepsy, Fetal Surgery for Myelomeningocele, Rehabilitation of Acute Spinal Cord Injury, Surgical Considerations for Patients with Polytrauma, Endovascular Approaches to Intracranial Aneurysms, and much more. - Hundreds of all-new video lectures clarify key concepts in techniques, cases, and surgical management and evaluation. Notable lecture videos include multiple videos on Thalamotomy for Focal Hand Dystonia and a video to accompany a new chapter on the Basic Science of Brain Metastases. - An extensive video library contains stunning anatomy videos and videos demonstrating intraoperative procedures with more than 800 videos in all. - Each clinical section contains chapters on technology specific to a clinical area. - Each section contains a chapter providing an overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology. - Summarizes translational research on brain imaging for brain tumors - Discusses limitations of neuroimaging for diagnosis and treatment - Presents advanced imaging technologies, including CT, MRI, and PET - Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more

Imaging of the Brain provides the advanced expertise you need to overcome the toughest diagnostic challenges in neuroradiology. Combining the rich visual guidance of an atlas with the comprehensive, in-depth coverage of a definitive reference, this significant new work in the Expert Radiology series covers every aspect of brain imaging, equipping you to make optimal use of the latest diagnostic modalities.

Practical Neuroimaging in Stroke, by Alejandro Rabinstein, MD, and Steven J. Resnick, is a neurology reference designed for anyone involved in treating stroke patients. It offers unique, thorough guidance-driven by nearly 500 completely original high-quality images from actual stroke cases-to help you learn and understand the clinical value of diagnostic neuroimaging. Examples of different diagnostic modalities-accompanied by succinct teaching messages-highlight a preference for those most commonly used in clinical practice and most typically interpreted by clinicians caring for patients at bedside. A consistent section format from chapter to chapter enables you to easily access the material. Brilliantly illustrated and clinically relevant, Practical Neuroimaging in Stroke is the closest thing to treating real-life patients! Features the work of today's leaders from the field of neurology to ensure that the material is current, accurate, and clinically relevant. Examines real-life stroke cases-driven by nearly 500 completely original images-that enable you to apply your knowledge to real-life situations and experience the next best thing to actually being in the field. Presents examples of different diagnostic modalities-accompanied by succinct teaching messages-that highlight a preference for those most commonly used in clinical practice and most typically interpreted by clinicians caring for patients at bedside. Discusses indications and potential pitfalls of the various imaging modalities, when pertinent, to make you aware of possible considerations. Uses a unique didactic approach that serves the knowledge needs of a wide range of experience levels. Follows a consistent section format from chapter to chapter that covers general concepts, case vignettes, case images, teaching messages, and selected readings, to help you quickly and easily locate the guidance you need.