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BOOK EXCERPT:
Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.
Product Details :
Genre |
: Medical |
Author |
: Dimitri Semizarov |
Publisher |
: John Wiley & Sons |
Release |
: 2008-11-03 |
File |
: 496 Pages |
ISBN-13 |
: 9780470409763 |
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BOOK EXCERPT:
Through comparative analysis, the genomes of a number of species are providing a deeper understanding of the human genome. This is highly useful in drug research, especially in the treatment of otherwise intractable conditions. Compiling first-hand descriptions of the pioneering achievements of prominent researchers, this text focuses on revolutionary advances in DNA-sequencing technology, new approaches to the organization and analysis of large phylogenetic data sets, new perspectives on evolution, and the development of novel antimicrobial drugs. This seminal volume demonstrates both the means and the fruits of cooperation across a number of fields, and in doing so lays the groundwork for continued progress.
Product Details :
Genre |
: Science |
Author |
: James R. Brown |
Publisher |
: CRC Press |
Release |
: 2007-12-03 |
File |
: 409 Pages |
ISBN-13 |
: 9781420008876 |
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BOOK EXCERPT:
An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
Product Details :
Genre |
: Medical |
Author |
: Dhavendra Kumar |
Publisher |
: Oxford University Press |
Release |
: 2008-02-15 |
File |
: 672 Pages |
ISBN-13 |
: 9780199720057 |
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BOOK EXCERPT:
Examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. Explores potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of drug discovery processes. Illustrates the use of Pathway Tools in a genomics-based drug discovery project.
Product Details :
Genre |
: Science |
Author |
: Thomas J. Dougherty |
Publisher |
: CRC Press |
Release |
: 2003-05-14 |
File |
: 256 Pages |
ISBN-13 |
: 9780824755133 |
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BOOK EXCERPT:
Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business
Product Details :
Genre |
: Medical |
Author |
: James J. O'Donnell |
Publisher |
: CRC Press |
Release |
: 2019-11-21 |
File |
: 697 Pages |
ISBN-13 |
: 9781351625142 |
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BOOK EXCERPT:
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
Product Details :
Genre |
: Science |
Author |
: Hugo Kubinyi |
Publisher |
: John Wiley & Sons |
Release |
: 2006-03-06 |
File |
: 487 Pages |
ISBN-13 |
: 9783527604029 |
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BOOK EXCERPT:
The book is intended to be a resource for students as well as scientists in education and for the general public to learn about proteomics and genomics. Chromosomes form the basis for our genetic heritage and are the code for protein synthesis. The Human Genome Map came out in 2002, and the Proteome Sequence Map is under currently being created by a global consortia initiative. Proteome and genome building blocks already form the basis of scientific research areas as well as large parts of the pharmaceutical and biomedical industry. The book initiative will provide the background to and our current understanding of these gene and protein areas, as well as describe how cutting-edge science is using these resources to develop new medicines and new diagnostics for patient care and treatment. The book will be useful for undergraduate students as well as university students and researchers who need a good understanding of genomics and proteomics within the clinical field. The book will also be targeted at a broad public as well as readers not specialized within this field. Dr. Marko-Varga is the head of the Head of Div. Clinical Protein Science & Imaging at the Biomedical Center, Dept. of Measurement Technology and Industrial Electrical Engineering, Lund University, and Professor at the 1st Department of Surgery, Tokyo Medical University, Tokyo, Japan.
Product Details :
Genre |
: Science |
Author |
: György Marko-Varga |
Publisher |
: Springer |
Release |
: 2014-08-26 |
File |
: 285 Pages |
ISBN-13 |
: 9789401792028 |
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BOOK EXCERPT:
Volume 1 Report also available (ISBN 9780108444517). Genomic medicine has developed from the sequencing of the human genome
Product Details :
Genre |
: Political Science |
Author |
: Great Britain: Parliament: House of Lords: Science and Technology Committee |
Publisher |
: The Stationery Office |
Release |
: 2009-07-07 |
File |
: 652 Pages |
ISBN-13 |
: 0108444503 |
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BOOK EXCERPT:
This book provides a comprehensive examination of the newest biopharmaceutical drugs. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, and contains a review of the Human Genome Project.
Product Details :
Genre |
: Medical |
Author |
: Susanna Wu-Pong |
Publisher |
: Springer Science & Business Media |
Release |
: 2010-01-11 |
File |
: 374 Pages |
ISBN-13 |
: 9781597455329 |
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BOOK EXCERPT:
Comparative Genomics and Proteomics in Drug Discovery gives an overview of how emerging genomic and proteomic technologies are making significant contributions to global drug discovery programs, and in particular the key role that comparative genomics and proteomics play within this strategy. Each chapter is written by respected authorities, with hands-on experience, from both academic and pharmaceutical backgrounds.
Product Details :
Genre |
: Medical |
Author |
: John Parrington |
Publisher |
: Taylor & Francis |
Release |
: 2018-12-07 |
File |
: 203 Pages |
ISBN-13 |
: 9781134155156 |