Facilitating the collaboration between the basic, translational, and clinical sciences, this book provides an overview of the genetic and epigenetic mechanisms underlying the formation and progression of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development gathers all of the molecular and cellular aspects of gynecological cancer together within one volume, providing detailed and up-to-date information on the etiology, diagnosis, and treatment of gynecological cancers. Gynecological Cancers: Genetic and Epigenetic Targets and Drug Development ​also discusses the racial and ethnic disparities in the treatment of gynecological cancers through cost effective modalities like single visit screening and diagnosis, well women clinics, and mobile clinics. Written and edited by leaders in the field, this volume within the Current Clinical Oncology series is an indispensable resource for today’s practicing oncologist.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older gynecological cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

This is a novel text that highlights the controversial areas in the management of gynecological cancers. None of the topics in this book have definitive answers; they represent the everyday decision-making facing gynecologists, oncologists, radiologists, pathologists and other health professionals treating women with these conditions. This book is not to be used as a traditional textbook; it is a text that specialists and trainees will use to help them weigh up the arguments that exist in a variety of areas in the treatment of gynecological cancers. Each chapter will have two or more authors, selected either for their opposing views or for their ability to provide an opposite view or opinion to the other. The content will be evidence-based, illustrating contrasting evidence and scientific opinion in the literature. Each chapter will close on a summary indicating the direction of research needed to address the issues being discussed.

This book is a practical guide to the use of modern radiation therapy techniques in women with gynecological cancers. Step-by-step instruction is provided on simulation, contouring, and treatment planning and delivery for cancers of the cervix, endometrium, vagina, and vulva. Beyond external beam radiation delivery, full details are presented on three-dimensional brachytherapy at all sites for which it is applicable. Moreover, in-depth guidance is offered on the various advanced techniques of radiation delivery, including intensity-modulated radiation therapy, image guidance for external beam and brachytherapy, and stereotactic body radiotherapy. Radiation therapy is a critical component of the multidisciplinary management of gynecological tumors. With modern technology, both external beam radiation and brachytherapy can be delivered in a highly conformal way. This requires precise contouring and accurate planning techniques. In clearly describing the indications for and the delivery of quality radiation therapy for gynecological tumors, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and radiotherapy residents.

Progress in Clinical and Biological Research, Volume 396 Etiology of Breast and Gynecological Cancers Proceedings of the Ninth International Conference on Carcinogenesis and Risk Assessment, Held in Austin, Texas, November 29–December 2, 1995 C. Marcelo Aldaz, Michael N. Gould, John McLachlan, and Thomas J. Slaga, Editors Accounting for 150 cancers per 100,000 people at risk, breast cancer and gynecological cancer together constitute a major public health concern. These cancers have a common target population, and many also have common etiological features, including hormonal factors, genetic changes in genes such as BRCA1, and environmental factors such as ionizing radiation, viruses, chemical xenobiotics, diet, and nutrition. Etiology of Breast and Gynecological Cancers explores important environmental and genetic factors that are key to the induction of these cancers. The book takes a broad perspective, with chapters contributed by laboratory investigators and clinicians, as well as by epidemiologists. It emphasizes validation and issues of extrapolation from animal models to humans and their impact on risk assessment, and it also discusses intervention strategies in terms of chemoprevention, which has the potential to reduce the morbidity and mortality from these cancers in women. Etiology of Breast and Gynecological Cancers explores a wide variety of topics, including: recent advances in the molecular genetics of hereditary breast and ovarian cancer molecular perspectives on cancer, the cell cycle, and the inherited disorder ataxia-telangiectasia genotoxicity of environmental agents in human mammary epithelial cells rodent model of reproductive tract leiomyomata estrogens and the genetic control of tumor growth Featuring 19 outstanding presentations from leading researchers in an array of disciplines, Etiology of Breast and Gynecological Cancers is an important resource for investigators and clinicians in oncology, epidemiology, and public health, providing new understanding of the sources of these disorders as well as new directions for treatment and prevention.

Breast Cancer and Gynecological Cancer Rehabilitation, edited by Adrian Cristian, MD, MHCM, provides today's clinicians with a concise, accessible resource covering the holistic rehabilitation of breast cancer patients. Beginning with a review of epidemiology, genetics, and pathophysiology of breast cancer, it then covers clinical assessment and treatment options before providing comprehensive coverage of rehabilitation. Containing practical information, best practices, and the latest advances and research, this book is a valuable reference for physical medicine and rehabilitation physicians and residents, as well as occupational and physical therapists. - Provides a clear understanding of the current medical, surgical, and radiation treatments for breast cancer. - Covers the whole spectrum of breast cancer rehabilitation, including the role of physical and occupational therapy, treatment of anxiety and depression, pain syndromes, integrative care, nutritional rehabilitation, palliative care, and more. - Offers a timely and convenient resource written by leading experts in breast cancer and rehabilitation.

Rare gynecological cancers kill all too commonly Gynecological cancer is a frightening prospect for women. It is terrifying also for physicians who need, but often can’t find, guidance on how to investigate and appropriately treat the tumors. Rare cancers provide greater challenges as information can be harder to find and more difficult to verify. Rare Gynecologic Cancers: Diagnosis and Management brings together all you need to know on these life-threatening diseases. Straightforward summaries of pathophysiologic processes lead to the investigations that will improve your diagnostic accuracy. This provides the basis for you to identify effective treatment strategies for your patients. Written by a world-leading team of Editors and Authors and covering cancers of the • Ovaries • Uterus • Vulva • Vagina • Cervix Rare Gynecologic Cancers: Diagnosis and Management will guide you to the best life-saving treatment for your patients.

Gynecologic cancers include malignancies of the female genital tract involving the vulva, vagina, cervix, uterus, fallopian tubes or ovaries. In the USA, 98,280 women had gynecological cancers in 2015, and 30,440 died of these cancers. World wide, the number of women who had cancers of the female genital tract was 1,085,900, in 2012 and the number of deaths was 417,600. Cancers of the uterus, cervix and ovary are most common. Widespread screening with the Pap test has allowed physicians to find per-cancerous changes in the cervix and vagina. This has assisted in identifying some invasive cancers early. Multidisciplinary team of experts includes specialists in medical oncology, gynecologic oncology, radiology, urology, radiotherapy, and surgery who work together to determine the best treatment approach for the patient. Recent progress in the development of new surgical techniques has transformed the treatment of gynecologic cancers, resulting in greater surgical precision and fewer complications. In addition targeted adjuvant therapy has become useful in improving the oncologic outcome of patients with these cancers.

Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis, resulting in more effective treatment and patient car