This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.

In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.

A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.

This innovative book focuses on HDL and its relationships to triglyceride-rich particles. It is an excellent resource for educating physicians and scientists about dyslipidemia and HDL metabolism, including many exogenous substances which interact with and influence HDL.

This book is the first of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. HDL comprises a diverse group of lipoproteins and its composition and metabolism are dynamic. In this volume, the focus is on the changes observed in HDL under different health statuses, with particular attention to the functional and structural correlations of HDL and apolipoprotein A-1. The impacts of a wide variety of factors on HDL are examined in depth, covering, for example, diet, exercise, smoking, age, diverse diseases, and different forms of environmental pollution. It has long been known that HDL has anti-atherosclerotic and antidiabetic properties, and more recently its anti-aging activities have been recognized. These benefits of HDL are highly dependent on its lipids, proteins, apolipoproteins, and enzymes, and specifically their composition and ratios. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians.

This bibliography is organized into sections on background; relationship of high density lipoprotein, triglyceride, and coronary heart disease; genetics and genetic syndromes; secondary causes of high triglyceride and low high density lipoprotein; measurement of high density lipoprotein and triglyceride; evidence from clinical trials; approach to high triglyceride and low high density lipoprotein; and monographs.

Advances in Lipid Research, Volume 18 is a seven-chapter text that brings together significant research studies on atherosclerosis. The opening chapter describes the pathological techniques in atherosclerosis research. The succeeding chapters deal with the influence of lipid-lowering drugs on bile acid metabolism and the cholesterol metabolism in ovarian tissue. Other chapters examine the principal role of sulfolipids and the influence of dietary linoleic acids on blood pressure regulation in rats. The closing chapters review the influence of nonnutritive fiber on lipid metabolism and the influence of fiber on lipid-associated diseases. These chapters also consider the techniques for polar lipid analysis. This book will be of great value to lipid chemists, biochemists, and researchers.