The Twelfth Annual Midwest Conference on Endocrinology and Metabolism continued the tradition of selecting a topic of inter est to a wide variety of scientists with interests in biology. The conference an "Hormones and Energy Metabolism" was dedicated appro priately to Dr. Samuel A. Brody, a leader in research in this field as described by Professor Johnson in this volume. A particular feature of these conferences has been the large proportion of time devoted to discussion of each paper and the pub lished proceedings have included edited transcripts of these dis cussions. Unfortunately, due to malfunction of the recording sys tem, major portians of the discussions were lost and, despite much effort, insufficient was salvageable tobe meaningful and helpful. Consequently, the editors decided to omit completely the discus sions except for a communication provided by Dr. Woodside. We again express our appreciation to the staff of Conferences and Short Courses, University of r~issouri-Columbia Extension Divi sion and especially to Dr. John Swanson who helped organize the multitude of administrative details; to ~lrs. Linda Bennett, CPS, for her continuing excellent efforts in typing the manuscripts for publication; and particularly to the sponsors, without whom there would have been no conference. Ralph R. Anderson f·1urray Heimberg David r~. Klachko vii CONTENTS Dedication: Dr. Samuel A. Brody xi Brody Memorial Lecture: Same Aspects of Energy Coupling by Mitochondria ...

Molecular Endocrinology, Third Edition summarizes the area and provides an in-depth discussion of the molecular aspects of hormone action, including hormone-receptor interactions, second messenger generation, gene induction, and post-transcriptional control. Thoroughly revised and updated, the Third Edition includes new information on growth factors hematopoietic-immune factors, nonclassical hormones, receptors, transduction, transcriptional regulation, as well as other relevant topics. Incorporating an abundance of new information, this text retains the self-contained, focused, and easily readable style of the Second Edition. - Includes discussion of recently characterized hormones - Recent advances in understanding chromatin remodeling are highlighted in this edition - Incorporates over 80 tables and 140 figures to beautifully illustrate recent biomedical advances

Growth, Nutrition, and Metabolism of Cells in Culture, Volume 2, summarizes the state of knowledge of the growth, nutrition, and metabolism of various types of cell cultures. The chapters are both detailed and comprehensive enough for the specialist and broad enough to provide a general background for the nonspecialist. The present volume deals with specialized mammalian, plant, and invertebrate cell systems and techniques. The book begins by tracing the history of the development of tissue culture. This is followed by separate chapters on the use of perfusion systems in cell and tissue culture; and the cultivation of muscle tissue, nerve tissue, and hematopoietic cells. Subsequent chapters discuss the use of cell culture to study mechanisms of hormone action; the cultivation of mammalian embryos; cultivation of cells from poikilothermie vertebrates; and the cultivation of arthropod cells and plant cells. This book will be valuable resource for investigators who routinely use cell culture techniques, as well as students and individuals in associated areas of cell and molecular biology.

This excellent book describes the roles of the suprachiasmatic nucleus (SCN) of the hypothalamus as a regulatory center of homeostatic mechanism and a circadian oscillator in mammals, including humans. The authors emphasize two important points based on their findings: 1) SCN plays a critical role in central regulation of energy metabolism through which a constant supply of glucose to the central nervous system (CNS) is well maintained; and 2) neurons responsible for the regulation of energy metabolism are located in the ventrolateral part of the SCN and receive retinal neural inputs through both the retinohypothalamic tract and the geniculohypothalamic tract. The authors then discuss the evolutionary importance of these points to the survival of mammals on earth. Other topics examined include the involvement of light in the regulation of neural activity of the autonomic nervous system through the retina and SCN, in addition to the relation of the SCN with regulations of other autonomic nerve functions, such as blood pressure and body temperature. Central Regulation of Energy Metabolism with Special Reference to Circadian Rhythm is important reading for researchers and students in neuroendocrinologists, neurobiologists, biochemists, endocrinologists, physiologists, chronobiologists, psychologists, pharmacologists, and others interested in the topic.

This unique and authoritative book presents an up-to-date overview of the many aspects of energy balance and its relationships to disease processes resulting from excess energy consumption and storage. It provides a comprehensive treatment of important research and clinical aspects of energy metabolism and obesity. It will be a valuable resource for endocrinologists, diabetes specialists, internists and family practitioners.

The prevalence of obesity in developed countries is fast becoming a health issue on par with infectious diseases and malnutrition. Research in this area has grown substantially and includes the neurochemical pathways of the hypothalamus and its role in regulating energy expenditures in the body. This volume in the Progress in Brain Research series examines the emerging role of the hypothalamus as a crucial link between the sensing of nutrients and the control of insulin sensitivity, glucose uptake, and glucose production, the integrative role of the hypothalamus in thyroid and bone metabolism, the interaction between circadian information and energy metabolism, and the important interplay between the immune system and energy metabolism.· All contributors are recognized experts in their respective specialities· Provides expanded coverage of hypothalamic mechanisms involved in energy metabolism· Includes many outstanding full-colour illustrations· Contains special sections on circadian rhythms, immune system, thyroid and bone metabolism

Studies in the Agricultural and Food Sciences: Energy Metabolism is a compilation of works on the energy metabolism in animals, especially animals of agricultural importance. The book is written by authoritative workers in the field and is divided into six parts; each chapter is based on a selected paper presented at the Eighth Symposium on Energy Metabolism held at Cambridge in September 1979. The text discusses feed evaluation; use of energy for maintenance and growth; and simulation models for energy exchange and growth. The book also covers the comparative aspects of energy metabolism; use of energy in production and lactation; and metabolic responses in the growing animal. The monograph is recommended for those who plan to study about energy metabolism of farm animals and its relationship with certain biological processes. The book will also appeal to those who develop feeds and methods that can help improve energy metabolism of farm animals.

Alteration in adequate energy balance maintenance results in serious disturbances such as obesity and its related metabolic disorders. In Mammals, energy balance is homeostatically controlled through hormonal and neuroendocrine systems which cooperation is based on cross-talk between central and peripheral signals. The hypothalamus as well as peripheral hormones among which adipokines from adipose tissue and thyroid hormones play a crucial role in energy homeostasis. Unraveling the physiological, cellular and molecular mechanisms through which hormonal and neuroendocrine systems regulate energy balance has been a long-standing challenge in biology and is now more necessary when considering the world-wide increasing prevalence of obesity. Indeed, recognizing and understanding the biochemical and nutrient signaling pathways contributing to the nervous and endocrine integration of physiological mechanisms involved in the normal and/or abnormal regulation of energy balance is fundamental also to the development of new, effective, and targeted treatments for obesity. Recent studies have highlighted the role of hypothalamic pro-opiomelanocortin-expressing neurons in the regulation of energy homeostasis by controlling energy expenditure and food intake. This is accomplished through a precise balance of production and degradation of a-melanocyte-stimulating hormone, an anorexigenic neuropeptide which is degraded to an inactive form unable to inhibit food intake by the key enzyme prolyl carboxypeptidase (PRCP), thus suggesting that pharmacologic approaches targeting PRCP may provide a novel and effective option for the management of obesity and its associated metabolic disorders. Indeed, efforts have been made to generate potent, brain-penetrant PRCP inhibitors. Weight loss due to negative energy balance is a goal for obese subjects not always reachable by dietary caloric restriction or increased physical activity. Lipid-lowering therapies have been suggested to have potential benefits, however, the establishment of comprehensive therapeutic strategies is still awaited. Recently, it has been reported that thyroid hormone (TH)- derivatives such as 3,5-diiodothyronine and 3-iodothyronamine possess interesting biological activities, opening new perspectives in thyroid physiology and TH derivatives therapeutic usage. Moreover, several studies, focusing on the interaction between thyroid hormone (TH), the autonomic nervous system and the liver, revealed an important role for the hypothalamus in the differential effects of TH on autonomic outflow to peripheral organs controlling energy balance. This Research Topic aims to give a comprehensive and integrate view of the factors involved in the endocrine and neuroendocrine signaling in energy balance regulation to highlight their involvement into physiological processes and regulatory systems as well as their perturbation during pathological processes.