This collection of chapters describes in detail the latest insights into the evaluation of resectability and neoadjuvant therapy to pancreaticoduodenectomy and distal pancreatectomy for pancreatic cancer. Shedding light on immunotherapy and gene therapy, this volume comprehensively covers treatments and procedures for the disease, allowing surgeons and trainees to gain an overview and explore innovative treatments. It also provides information on various cases using tools such as endoscopic ultrasound, MDCT, PET for diagnosis and laparoscopy and robotic resection methods. Edited and authored by pioneering professionals, Diagnosis and Treatment for Pancreatic Cancer is a valuable resource for gastroenterologists, medical oncologists, surgical oncologist and general surgeons interested in treatment of pancreatic cancer care.

Gastrointestinal Malignancies: New Innovative Diagnostics and Treatment summarizes new advantages in the diagnosis and treatment of gastrointestinal malignancies, thereby providing the most current and up-to-date knowledge on gastrointestinal malignancies to medical students, gastroenterologists, general surgeons, oncologic surgeons, and oncologists.This book will feature the progresses made on treatment and diagnosis of gastrointestinal malignancies in the last ten years and provides the most current diagnostic and therapeutic modalities to the readers. The book will be an excellent reference tool for physicians and surgeons working in the field of gastrointestinal malignancies.Editors of the book are experts from both the western and eastern parts of the world.

Pancreatic cancer remains one of the leading causes of cancer-related deaths. The survival remains extremely low with an estimated overall 5-year survival rate of approximately 5%. For patients who are able to undergo surgery the 5-year survival rate is approximately 20-30%. Unlike other solid organ malignancies, the 5-year survival of pancreatic cancer has not improved significantly over the last few decades. There is an urgent need for more effective treatments for both resectable and unresectable cancer to improve outcomes for patients Innovations on the early, non-invasive diagnosis and more efficient treatments are desperately needed to further improve outcomes. It is imperative that when new techniques are introduced into clinical practice, they are done so in a manner that is transparent to ensure. Furthermore, the technique should be described in detail alongside patient selection (and evolution with time), governance arrangements, clinical- and patient-reported outcomes to ensure incremental learning occurs so promising innovations are adopted rapidly.

This collection of chapters describes in detail the latest insights into the evaluation of resectability and neoadjuvant therapy to pancreaticoduodenectomy and distal pancreatectomy for pancreatic cancer. Shedding light on immunotherapy and gene therapy, this volume comprehensively covers treatments and procedures for the disease, allowing surgeons and trainees to gain an overview and explore innovative treatments. It also provides information on various cases using tools such as endoscopic ultrasound, MDCT, PET for diagnosis and laparoscopy and robotic resection methods. Edited and authored by pioneering professionals, Diagnosis and Treatment for Pancreatic Cancer is a valuable resource for gastroenterologists, medical oncologists, surgical oncologist and general surgeons interested in treatment of pancreatic cancer care.

Recent Advances in Nanocarriers for Pancreatic Cancer Therapy reviews thriving strategies concerning pancreatic cancer therapy, thoroughly describing the most recent developments in emerging modern drug delivery systems focused on, and derived from, nanotechnology. By providing a holistic understanding of the molecular pathways, conventional therapy and novel nanocarriers mediated drug delivery against pancreatic cancer, this work can be considered a complete package. The book offers a solution to the dissemination of data from a broad range of resources by providing an overview of the molecular pathways and conventional therapy of pancreatic cancer, the application of various nanocarriers, and more. This book equips scientists, clinicians and students to make rational treatment approaches based on nanomedicine for improving and extending the human life against pancreatic cancer. • Explains the complete journey of nanomedicine-based approaches in pancreatic cancer drug delivery from fundamental to most recent applications • Provides information about various approaches for the diagnosis and treatment of pancreatic cancer using the latest advancement in cutting-edge nanomedical technologies • Discusses the perspectives of the technologies explored to date based upon the fi ndings outlined in highly organized tables, illustrative fi gures, and fl ow charts for easy consult and comprehension

In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Tamas Gonda brings his considerable expertise to the topic of Advances in Diagnosis and Therapy of Pancreatic Cystic Neoplasms. Some estimates predict that over 2% of all patients 65 and older may have a pancreatic cyst and over 5% of those who undergo cross-sectional imaging will be found to have a cystic lesion. This issue provides an overview of current diagnostic approaches and emerging data on some of the novel imaging and biomarker strategies that improve accuracy. Top experts cover current guidelines for diagnosis and surveillance of pancreatic cystic lesions, high-risk individuals, the decision-making process, and much more. - Contains 12 practice-oriented topics including burden of new pancreatic cyst diagnosis; next generation of radiologic assessment for pancreatic cystic neoplasms; endoscopic therapy for pancreatic cysts; surgical innovation for cystic neoplasms; and more. - Provides in-depth clinical reviews on advances in diagnosis and therapy of pancreatic cystic neoplasms, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Current Management of Pancreatic Cancer, An Issue of Surgical Oncology Clinics of North America, E-Book

The encyclopedic guide to the pancreas for practicing clinicians and surgeons In the past decade extraordinary developments in diagnostic and therapeutic radiology and endoscopy have been coupled with major advances in surgical techniques and basic sciences. As a result the management of pancreatic disorders is now handled by a multidisciplinary team. This book shows you how to achieve superior patient management by taking the team approach to in-hospital care. Fully revised and updated, this new edition of The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery details the latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known pancreatic disorders. The Editor and author team are leading pancreatologists of high international repute and they present global best-practice and evidence-based knowledge in this comprehensive reference. A timely section on early and late outcome data considers the benefits of management including chemotherapy and immune therapy. Incorporating evidence-based data, the book also focuses on early diagnosis, limited surgical treatment, oncology, treatment results and the option of transplantation. This new edition contains more than 400 illustrations, line drawings and radiographs to provide a step-by-step approach to endoscopic techniques and surgical procedures. With The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, Second Edition, you can achieve a greater understanding of current diagnostic, medical and surgical treatment principles in one authoritative reference point.

Gastrointestinal cancer is one of the most prevalent causes of cancer-related deaths in the world. Recent research demonstrates that phytochemicals are critical in preventing and managing gastrointestinal cancer. The increased intake of phytochemicals could reduce the risk of cancer by inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms are also known to counter Helicobacter pylori infection and modulate gut microbiota. There is preliminary data suggesting that daily supplementation with high doses of certain vitamins combined with conventional therapeutic agents may enhance their growth inhibitory effects on tumor cells and protect normal tissues against some of their toxic effects. This book attempts to fill gaps on the role of phytonutrients in the treatment of cancer in the gastrointestinal tract (GIT). It discusses the action of individual vitamins on cellular and molecular parameters and describes how vitamins inhibit protein kinase C activity, increase the production of certain growth factors, and modulate the expression of a number of oncogenes. The book is divided into 2 parts. The first part summarizes the pathophysiology of GIT cancers and introduces readers to anticancer phytonutrients. A chapter on the status of FDA approved nutraceuticals rounds up this section. The second part of the book provides a systematic review on the different plant derived chemicals that can be used to treat GIT cancer. Each chapter in this section focuses on a specific type of phytochemical agent and its molecular mechanisms relevant to the disease. This book will give the reader a holistic view of gastrointestinal cancer treatment and the value of natural compounds in developing functional food and drugs for preventive medicine.