Mitral valve prolapse (MVP), consisting of an abnormal protrusion of mitral leaflets into the left atrium, is the main cause of severe mitral regurgitation and it often requires surgical or interventional correction. It mainly represents a typical adult disease with an average prevalence in industrialized countries ranging from 2 to 8%, but even the pediatric population may be affected showing specific features concerning both anatomy and treatment. Although its existence and clinical characteristics are known for several decades, every aspect of this pathological condition is in continuous evolution, being the subject of biologists’, cardiologists’ and surgeons’ active research. The aim of the present Research Topic is to address the MVP entity in its completeness, trying to describe all actual knowledge concerning molecular mechanisms, different clinical presentations (fibroelastic degeneration in elderly people or Barlow disease in young patients), diagnostic findings and tools (mainly represented by echocardiography and Nuclear Magnetic Resonance), their specific application to newly developed transcatheter and minimally invasive treatments, indications, surgical management and interventional strategies. For all these big chapters, special attention will be addressed to show temporal knowledge evolution and new elements acquisition, since the central message is that MVP is in flux and far from full comprehension.

This book includes original unpublished contributions presented at the International Conference on Data Analytics and Management (ICDAM 2021), held at Jan Wyzykowski University, Poland, during June 2021. The book covers the topics in data analytics, data management, big data, computational intelligence, and communication networks. The book presents innovative work by leading academics, researchers, and experts from industry which is useful for young researchers and students.

The only reference wholly dedicated to this complex topic, Diagnosis and Treatment of Mitral Valve Disease: A Multidisciplinary Approach provides authoritative, must-have information on the disease processes affecting the mitral valve, interpretation of diagnostic studies, and medical, transcatheter, and surgical treatments needed for mitral valve repair. Using a multidisciplinary approach, Drs. Scott Goldman and William Gray oversee a "who's who team of contributing authors who offer a holistic view of the modern treatment of mitral valve disease for today's cardiac surgeons, cardiologists, and other cardiac team members. - Includes foundational chapters on anatomy and pathophysiology of the mitral valve—critically important topics when treating multiple complex and highly dynamic structures that function as a single unit. - Covers diagnostic tools, medical treatments, surgical therapies, and transcatheter therapies, and provides tips for developing a successful mitral valve program (with baseline thresholds, common pitfalls, and a checklist for hospitals). - Uses an accessible, quick-reference format that features takeaway chapter openers, bulleted key points, end-of-chapter summaries, a common nomenclature and glossary of terms, key references, and ample line drawings, photographs, tables, charts, and graphs throughout. - Incorporates the essential role of imaging in structural transcatheter interventions, including echocardiography and transcatheter edge-to-edge repair (TEER), and their uses in diagnostic work-up, procedural planning, intra-procedural guidance, and follow-up. - Features dozens of procedural videos, including transthoracic echocardiogram; cardiac MRI for mitral regurgitation; transcatheter mitral valve repair; transcatheter valvuloplasty; percutaneous mitral valve interventions; MitraClipTM positioning; and many more. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Ideally suited for those clinicians who have already mastered basic principles, The Practice of Clinical Echocardiography, 6th Edition, provides expert guidance on interpreting echocardiographic images and Doppler flow data. Through practical, clear, and carefully edited content, world-renowned expert Dr. Catherine M. Otto and her team of more than 65 leaders in echocardiography demonstrate how to apply advanced knowledge to daily clinical decision making. Newly reorganized sections cover advanced principles for the echocardiographer, best practices for echocardiography laboratories, transthoracic and transesophageal echocardiography, intraoperative and interventional echocardiography, and point-of-care cardiac ultrasound. - Provides an in-depth, clear, and concise review of the latest clinical applications of echocardiography with an advanced level of discussion, now thoroughly updated with new clinical knowledge, new treatments and guidelines, the latest evidence, and innovations in advanced echocardiographic imaging. - Reviews the technical aspects of data acquisition and analysis with an emphasis on outcomes. - Covers key topics such as transcatheter interventions for valvular heart disease, prosthetic valve dysfunction, the athletic heart, cardiac assist devices, cardio-oncology, heart disease in pregnancy, advanced 3D echocardiography, strain imaging, stress echocardiography, and much more. - Includes updated illustrations throughout—nearly 1,000 echocardiograms, Doppler tracings, anatomic drawings, and flow charts for diagnostic approaches—as well as hundreds of echo video clips keyed to images in the text. - Discusses limitations, pitfalls, and alternate approaches. - Features chapter summary boxes with new "Quick Reviews" and a practical approach to echocardiographic data acquisition, measurement, and interpretation. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access bonus images plus all of the text, figures, and references from the book on a variety of devices.