Neurodegenerative diseases share the common property of neuronal loss in the higher-order association and limbic cortices or the extrapyramidal and pyramidal motor systems. In addition, oligodendroglia, astrocytes, and microglia have been implicated in fundamental abnormalities of virtually every neurodegenerative disorder. The particular system affected, more importantly the distribution of the pathology, determines the clinical presentation. While the most common dementia and movement disorders, such as Alzheimer’s disease, Lewy body disease, and frontotemporal lobar degeneration with TDP-43 pathology, including amyotrophic lateral sclerosis, have been extensively studied, many less common, even rare neurodegenerative disorders have gained more attention in recent years. This shift in focus is perhaps driven, in part, by the severely underestimated financial costs associated with these diseases, as well as the immense emotional burden they impose on patients and their caregivers. This book presents the most recent developments in rare neurodegenerative disorders. Insights gained from the investigation of pathophysiological mechanisms of these rare disorders may lead to the development of therapeutic strategies for more prevalent neurodegenerative disorders. In addition to highlighting advancements in research, the book discusses the significant challenges faced by researchers and healthcare professionals in diagnosing and treating rare diseases. It emphasizes the critical need for continued funding and support for research, which is essential to improving patient outcomes and advancing our understanding of these complex conditions.

“This book is highly recommended for those who will engage with pediatric patients as an excellent starting point to learning most clinically relevant management." ---Doody's Review Service, 3 stars Comprehensive and accessible, Pediatric Neurology is the first reference designed for trainees and nonspecialists in search of targeted information on the diagnosis and management of neurologic conditions in children. Providing a broad window on the primary disorders seen in childhood, this book interweaves the expertise of field leaders from top national institutions to concisely distill the foundations of clinical pediatric neurology. Complete with up-to-date disease guidelines and evidence-based treatment recommendations, this book serves as a starting point for physicians and other health professionals who wish to delve into fundamentals of current pediatric neurology practice. Beginning with an overview of the clinical assessment of infants and children, the book features dedicated chapters to all major disorders and conditions likely to be encountered in the pediatric population. Chapters include current information on epidemiology, clinical manifestations, diagnosis, and approaches to management for each condition in addition to tables summarizing key takeaways and detailed illustrations. Using plain language and a clear presentation of information throughout, the book is packed with the clinical wisdom needed for tackling such a complex field. With special emphasis on essential patient care concepts, Pediatric Neurology is the trusted resource for residents, general neurologists, pediatricians, medical students, and other practitioners who care for children and adolescents with neurological disease. Key Features: Introduces the foundations of clinical pediatric neurology Multi-purpose resource for point-of-care use, clinical rotations, or board preparation Organized by disease category to enhance accessibility and retrieval of key information Features chapters written by leading educators and clinicians in the field Incorporates up-to-date disease guidelines, latest FDA-approved drugs, and evidence-based treatment recommendations Purchase includes digital access for use on most mobile devices or computers

Child Neurology: Its Origins, Founders, Evolution and Growth, Second Edition updates the first biographical study of important contributors to the field of child neurology, consisting of over 250 biographical sketches written by over 100 physicians specializing in neurology, child neurology, pediatrics and obstetrics. Organized chronologically into six chapters, beginning before 1800 and continuing to the present, Child Neurology traces the emergence of child neurology as a separate specialty from its roots in pediatrics and neurology. With a definitive historical introduction by the editor, Dr. Stephen Ashwal. This new edition will feature a new section on The Dynamic Growth and Expansion of Child Neurology: The Late Twentieth Century (1960 to 2000+) and features about 138 new biographical sketches of leaders in the field during this recent time frame. Child Neurology: Its Origins, Founders, Evolution and Growth, Second Edition will be published on behalf of the Child Neurology Society, a professional society that strives to foster recognition and support for children with neurological disorders and to promote and exchange national and international scientific research, education, and training in the field of neurology. - Identifies top contributors to child neurology research from the 1800s to today - Includes 238 biographical sketches of contributors and their scientific research - Contains 138 new biographies on contributors from the late 20th and early 21st centuries - Authored by physicians and published by the Child Neurology Society

Primary health care providers such as pediatricians and family medicine physicians commonly encounter children with neurologic symptoms such as headache, double vision, facial weakness etc. Most books currently available in the specialty of pediatric neurology are “condition” or “disorder” based, and most of them are geared towards pediatric neurologists, not generalists who take care of children. A common thread amongst most currently available books in Pediatric Neurology is that the practitioner already knows what “condition” or “disorder” the child is suffering from. This book focuses on symptoms to a large extent. However, children with chronic neurological conditions will follow up with their primary care physicians after their visit with the sub-specialists. They may have questions or ongoing concerns regarding the diagnosis that has been made or being considered. This book attempts to provide information to the primary care physician regarding management and follow up of such children as well. This book serves as a guide for busy clinicians who take care of children presenting with neurological symptoms- with special emphasis on symptoms that are commonly encountered in clinical practice. For each symptom, a brief introduction is given as well as a definition and epidemiologic information for the given symptom. Readers are also instructed on what historical features and physical examinations are essential in narrowing the differential diagnosis. A recommendation on the management of the condition is then established. Instructions on when one should refer the patient to subspecialists for further evaluation and management are clearly laid out. Finally, a list of appropriate resources is provided for families, as well as clinical pearls that can be quickly scanned when one is pressed for time. The overarching goal of this book is to enable the primary care physician to make a confident diagnosis, triage efficiently and initiate treatment if need be. Written by experts in the field, Symptom-Based Approach to Pediatric Neurology is a valuable resource for evaluation and management of children presenting with neurologic symptoms for primary care providers who take care of children.

Cerebral palsy is a debilitating disease that affects the everyday life of patients and their caregivers. Understanding its pathophysiology, preventing avoidable factors, and effectively treating the disease with the most appropriate approach is paramount in the management of patients with cerebral palsy. This book presents up-to-date information about the etiology, pathophysiology, social aspects, and optimum care and treatment alternatives of this chronic condition.

This title demystifies artificial intelligence (AI) and analytics, upskilling individuals (healthcare professionals, hospital managers, consultants, researchers, students, and the population at large) around analytics and AI as it applies to healthcare. This book shows how the tools, techniques, technologies, and tactics around analytics and AI can be best leveraged and utilised to realise a healthcare value proposition of better quality, better access and high value for everyone every day, everywhere. The book presents a triumvirate approach including technical, business and medical aspects of data and analytics and by so doing takes a responsible approach to this key area. This work serves to introduce the critical issues in AI and analytics for healthcare to students, practitioners, and researchers.

TOPICS IN THE BOOK Ethical Concerns in Accessing Healthcare Information from Social Media by Patients with Terminal Diseases in Kenya: Opportunities and Challenges Influence of Stakeholder Dynamics on Performance of Free Maternal Healthcare Project in Kenya, a Case of Homabay County Assessing the Degree of Determinant Impact on the Management Outcomes of Drug Sensitive Pulmonary Tuberculosis in Sierra Leone-A Case Study of Rural Bo District Utilizing Health Informatics as a Means of Assisting in Eliminating Health Disparities in Diverse Populations and Improving Health Care Quality

This handbook provides an overview of the nature, prevalence, and causes of sleep problems in children with autism spectrum disorder (ASD) and examines the process of using functional behavior assessment (FBA) to treat sleep disorders. It describes several evidence-based treatments and explores how these align with the outcomes of the FBA process, including case illustrations of the assessment and treatment process. The handbook discusses the application of FBA in family contexts, including: The effects on children and families of successful interventions with sleep. How to conduct FBA with clinically complex families. Including the child in the intervention. The evidence of efficacy of other treatment approaches. The handbook addresses sleep problems that are highly prevalent among children and young people with ASD, including sleep onset delay, frequent and prolonged night waking, and unwanted co-sleeping. It explores the profound secondary effects that sleep problems may have on children’s daytime functioning as well as child and parent health and wellbeing. The handbook discusses the causes of sleep problems in individuals with ASD, which may be multifaceted and complex and include physiological, environmental, cognitive etiologies yet almost always have a behavioral or learned component. It examines how FBA can be used to characterize challenging behaviors and identify the antecedents (e.g., environmental context) and consequences that affect such behaviors. The volume details the process of using FBA to assess and treat sleep problems in children with ASD. Clinical Handbook of Behavioural Sleep Treatment in Autism is a must-have resource for clinicians, therapists, and other practitioners as well as researchers and graduate students in clinical child and school psychology, behavioral therapy, social work, public health, developmental psychology, pediatrics, family studies, and child and adolescent psychiatry.