Microbiome and the Eye: What's the connection? highlights how alterations in the gut and eye microbiomes can lead to systemic immune alterations with subsequent effects on the eye. The book is divided into two sections, one highlighting how alterations in the gut microbiome impact various components of health outside the gut, with a focus on the immune system and inflammatory mediators, and the second focusing on studies on a variety of ocular diseases, including ocular surface diseases/dry eye, keratitis, uveitis, glaucoma, and retinopathy to gut dysbiosis. With its translational approach, the book is suitable for both researchers and clinicians. The book will help readers understand the mechanisms in which gut and eye microbiome composition may influence health in multiple compartments, with a focus on eye diseases. - Helps researchers understand the clinical eye diseases that have been linked to gut microbiome abnormalities - Helps clinicians understand the mechanisms in which gut microbiome composition may influence health in multiple compartments - Provides a foundation for future studies that consider gut microbiome manipulations as a treatment for specific eye diseases

This book provides an integrated review of the human ocular microbiome. It documents the discovery of ocular surface microbes by the conventional cultivable method and next generation sequencing technologies in both healthy and diseased (keratitis, uveitis, endophthalmitis, blepharitis, conjunctivitis etc.) eyes. The book further discusses the confounding factors that influence the microbiome, mycobiome and virome. The chapters cover niche-specificity with reference to skin, eyelid- margin, hands etc. It highlights the concept of core genera, dysbiosis and discriminating genera and covers the functional relevance of the dysbiotic microbiome, mycobiome and virome with respect to ocular diseases. The book includes topics on the relevance of molecular mechanisms, including quorum-sensing and mucin metabolism to ocular disorders, such as dry eye; and, microbiome-based therapies for treating of ocular disorders like vernal keratoconjunctivitis. The book is essential for microbiologists studying the human eye, ophthalmologists treating eye infection and trauma. It also caters to students of medical microbiology and medicine.

The book covers antimicrobial resistance in ocular diseases, including the microbiology of the ocular surface, the history and origin of antimicrobials, methods to detect antimicrobial resistance and antimicrobial resistance genes, and the impact of antimicrobial resistance on a variety of ocular diseases. The inclusion of chapters covers bacterial keratitis, fungal keratitis, viral keratitis, acanthamoeba keratitis, endophthalmitis, dry eye disease, post fever retinitis, and uveitis including management and prevention of antimicrobial resistance. Key Features: Focusses on various ocular diseases and their association with antimicrobial resistance; Includes data relevant to drug industry to develop drugs for specific ophthalmic use; Illustrates ocular surface microbiome under various diseased condition;s Highlights the microbes associated with the conjunctiva and cornea of the human eye; Enumerates the changes in the abundance and diversity of the antimicrobial resistant (AMR) microorganisms in the diseased eye. This book is aimed at professionals and researchers in ophthalmology, microbiologists, infectious disease specialists, and public health.

Microbes, Microbial Metabolism and Mucosal Immunity: An Overview presents a concise and well-vetted treatise on the study of microbiome and microbial metabolites. This volume is up-to-date with the most recent developments from the last decade. It encompasses the interaction of immunity and microbes — and their metabolites — from different mucosal organs including gastrointestinal system, lung, oral cavity, eye. Along with the efficiency of the immune system in inhibiting the growth and proliferation of microbes, the volume discusses how the mediators of the immune system can be targeted to develop therapies.This book presents the latest methods, gives broad and systematic coverage of most mucosal systems and diseases, and takes a fresh perspective that looks at the functional aspects of change in the microbiome. The study of microbiome and microbial metabolites and their roles in host mucosal immunology is a rapidly developing area of research. One major way in which the microbiome influences the host is through altered metabolism. Metabolites, readily available to the host, engender significant consequences. Microbial metabolites have been shown to impact the disease processes in both proximal and distal organs, including the brain in several neurocognitive disorders. - Offers a concise solution for the study of microbiome, microbial metabolism, and mucosal immunology - Presents contemporary studies that incorporate the latest research methods - Gives a broad and systematic accounting of most mucosal systems and diseases - Looks at the functional aspects of changes to the microbiome as well as specific changes to microbiota - Affords entry-level and advanced readers with the theory and knowledge needed for further research

Microbiome and the Eye: What's the connection? highlights how alterations in the gut and eye microbiomes can lead to systemic immune alterations with subsequent effects on the eye. The book is divided into two sections, one highlighting how alterations in the gut microbiome impact various components of health outside the gut, with a focus on the immune system and inflammatory mediators, and the second focusing on studies on a variety of ocular diseases, including ocular surface diseases/dry eye, keratitis, uveitis, glaucoma, and retinopathy to gut dysbiosis. With its translational approach, the book is suitable for both researchers and clinicians. The book will help readers understand the mechanisms in which gut and eye microbiome composition may influence health in multiple compartments, with a focus on eye diseases.

Did you know that 10-30 per cent of adults struggle with chronic insomnia? In How to Sleep Better, Allied Functional Medicine and Ayurvedic health counsellor Deepa Kannan explores the root causes of poor sleep and provides expert tips and advice that will enhance the quality and duration of your resting hours and rejuvenate your life. She explains how and why we sleep, what our body does while we rest, and the reasons behind many common sleep problems. She also enlightens us on how to use each of our ten senses or indriyas mentioned in the Upanishads--the eyes, ears, nose, skin, tongue, rectum, genitals, legs, hands and mouth--effectively to enjoy a restful night.This comprehensive guide offers an easy-to-adapt, prescriptive lifestyle programme that will empower us with incredible tools for a healthier life.

Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer's disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold's reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book. - Addresses the emerging hypothesis of a dysfunctional microbiome vagus nerve brain circuit in Alzheimer's disease and associated diseases and medical conditions - Covers dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea - Presents the conceptual model of food and gut microbial tryptamine vagus nerve circuit - Covers human health and intellectual abilities in the context of both the human genome and the human microbiome

The Eye: Basic Sciences in Practice provides highly accessible, one-stop coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also core reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. Building on previous success, this fifth edition has been fully revised in line with current curricula, key research developments and clinical best practice. It succinctly incorporates critical developments in fast-moving fields related to the eye and vision, including genetics, pharmacology, microbiology, immunology, pathology, neurophysiology, neuroanatomy and imaging. Topical coverage includes: - Major advances in the search for new genes underpinning disease in ophthalmology - The emergence of new infections such as Ebola, Zika and COVID-19 - The importance of the gastrointestinal tract as an immune organ and its functional dependence on the microbiome - Key aspects of melanopsin, melatonin and new ways of light sensing Also, (print purchasers) benefit from access to the complete, fully searchable electronic text, with integrated video and other bonus materials to further explain and expand on key concepts. This combines to make The Eye a more flexible, comprehensive and engaging learning package than ever before. - The only all-embracing textbook of the basic sciences suitable for trainee ophthalmologists, optometrists and vision scientists. - Utilising an attractive page design with over 300 colour drawings and 200 photographs this is an attractive and accessible text to learn from. - The text presents in a readable form an account of all the basic sciences necessary for an understanding of the eye – anatomy, embryology, genetics, biochemistry, physiology, pharmacology, immunology, microbiology and infection and pathology.