The Essentials in Ophthalmology series represents an aged by readership acceptance of the first two series, unique updating publication on the progress in all sub- each of eight volumes. This is a success that was made specialties of ophthalmology. possible predominantly by the numerous opinion-lead- In a quarterly rhythm, eight issues are published cov- ing authors and the outstanding section editors, as well ering clinically relevant achievements in the whole field as with the constructive support of the publisher. There of ophthalmology. This timely transfer of advancements are many good reasons to continue andstill improve the for the best possible care of our eye patients has proven to dissemination of this didactic and clinically relevant be effective. The initial working hypothesis of providing information. new knowledge immediately following publication in the peer-reviewed journal and not waiting for the textbook G. K. Krieglstein appears to be highly workable. R. N. Weinreb We are now entering the third cycle of the Ess- tials in Ophthalmology series, having been encour- Series Editors Preface Our knowledge and understanding of immune-mediated the most recent research material available. The scope of diseases has increased exponentially over the past few the chapters ranges from well-recognized immune dis- years, especially in the areas of immunopathogenesis and ders such as cornea transplantation, uveitis and diabetic immunotherapeutics.

Microbiome and the Eye: What's the connection? highlights how alterations in the gut and eye microbiomes can lead to systemic immune alterations with subsequent effects on the eye. The book is divided into two sections, one highlighting how alterations in the gut microbiome impact various components of health outside the gut, with a focus on the immune system and inflammatory mediators, and the second focusing on studies on a variety of ocular diseases, including ocular surface diseases/dry eye, keratitis, uveitis, glaucoma, and retinopathy to gut dysbiosis. With its translational approach, the book is suitable for both researchers and clinicians. The book will help readers understand the mechanisms in which gut and eye microbiome composition may influence health in multiple compartments, with a focus on eye diseases. - Helps researchers understand the clinical eye diseases that have been linked to gut microbiome abnormalities - Helps clinicians understand the mechanisms in which gut microbiome composition may influence health in multiple compartments - Provides a foundation for future studies that consider gut microbiome manipulations as a treatment for specific eye diseases

This book reviews the various emerging infectious diseases that show a significant association with uveitis, describing and explaining their ocular manifestations with the aid of color illustrations. In addition, it presents brief reports of further emerging infections that are associated with uveitis in rare cases. The coverage is wide ranging, encompassing diverse emerging bacterial, viral, parasitic and fungal infections. Individual chapters are also devoted to important re-emergent diseases such as syphilis and tuberculosis, with the focus on new data on epidemiology, diagnosis and management. Emerging infectious diseases are defined as “those whose incidence in humans has increased within the past two decades or threatens to increase in the near future”. Emergence may be due to the spread of a new agent, to the recognition of an infection that has been present in the population but has gone undetected, or to the realization that an established disease has an infectious origin. This book will be an invaluable source of information on all aspects of uveitis in these diseases.

[Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis—an imbalance in the composition and organization of microbial populations—could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various—even distant—areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut–brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.]

Comprehensive and readable, Whitcup and Nussenblatt's Uveitis, 5th Edition, covers every aspect of this complex subspecialty in a single convenient volume. This clinically relevant guide covers the medical, pharmacological, and surgical treatment of uveitis in a visually rich, full-color format, offering a complete overview for today's clinicians. New and updated case studies, key points boxes, and more than 400 images and graphics highlight major clinical points and provide insight into real situations that you can apply in practice. - Features multiple chapters on diagnostic approach to help you meet the challenge of making accurate diagnoses. - Reflects advancements and new developments on all aspects of uveitis including new medical and surgical treatments. - Covers key topics such as the use of PCR in diagnostic testing, cataract surgery in patients with uveitis, the use of OCT in diagnosis and treatment, new infectious causes of uveitis (including Zika and Ebola), and novel treatments for inflammatory eye disease. - Includes new clinical photographs, illustrations, and OCT images throughout. - Reviews new randomized clinical trials of new uveitis therapy, as well as the approach to patients with HIV and HIV-associated ocular diseases including CMV retinitis and immune recovery uveitis. - Provides expanded information on masquerade syndromes with important tips on diagnosis and management of intraocular lymphoma.

Uveitis is the comprehensive reference you need for a balanced approach to basic science and clinical application. Robert B. Nussenblatt and Scott M. Whitcup provide a cohesive and integrated discussion of the topic, covering everything from the role of surgery to AIDS to anterior uveitis and more. This new edition even includes full color throughout with 400 photographs and illustrations. Comprehensive yet readable, this resource packs everything you need in patient evaluation and management to achieve optimal results. Covers the medical, pharmacological, and surgical treatment of uveitis to serve as a complete overview of all uveitis related information. Features multiple chapters on diagnostic approach to help you overcome challenges in making accurate diagnoses. Provides additional information on inflammatory eye diseases in chapters on scleritis, masquerade syndromes, and the role of inflammation in other ocular diseases for more comprehensive coverage. Includes illustrated case studies to supplement major clinical points and provide insight into real situations that you can apply in practice. Highlights important information in key points boxes that make it easy to locate crucial points on each topic. Includes access to the fully searchable text online at expertconsult.com. Features significant updates to the chapters on the role of surgery in the patient with uveitis, acquired immune deficiency syndrome, anterior uveitis, white dot syndromes, and masquerade syndromes. Covers advancements and new developments on all aspects of uveitis including new medical and surgical treatments. Presents photographs in full color to better prepare you for actual clinical diagnosis.

Get the quick answers you need on every aspect of clinical ophthalmology and apply them in your day-to-day practice. The latest edition of Ophthalmology by Drs. Yanoff and Duker presents practical, expert, concise guidance on nearly every ophthalmic condition and procedure, equipping you to efficiently overcome whatever clinical challenges you may face. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Focus on the clinically actionable information you need thanks to a more streamlined format. Make optimal use of the newest drug therapies, including Anti-VEGF treatment for wet ARMD and bevacizumab treatment for complications of diabetes. Get authoritative guidance on the newest treatment options for cornea disorders, including evolving ocular surface reconstruction techniques and new cornea procedures such as DSEK. Take it with you anywhere. Access the full text, video clips, and more online at Expert Consult. Apply the latest advances in the diagnosis and treatment of ocular disease, including new drug therapies for retinal disorders; today’s expanded uses of optical coherence tomography (OCT) and high-resolution imaging modalities; new corneal, cataract and refractive surgical approaches; and new developments in molecular biology and genetics, ocular surface disease, glaucoma testing, neuro-ophthalmology, uveitis, ocular tumors, and much more. Visualize how to proceed by viewing more than 2200 illustrations (1,900 in full color) depicting the complete range of clinical disorders, imaging methods, and surgical techniques. Hone and expand your surgical skills by watching 40 brand-new videos demonstrating key techniques in cornea, cataract, refractive, retina and glaucoma surgery. Spend less time searching thanks to a user-friendly visual format designed for quick, "easy-in easy-out" reference and an instant understanding on any topic.