Motor System Disorders: Normal Physiology and Function and Neuromuscular Disorders summarizes recent advances and best practice for understanding normal physiology and function of the larger motor system as well as the diagnosis, course, and treatment of neuromuscular disorders. The work will include neuroanatomy, circuits and synapses. It discusses how different parts of the brain contribute to motor control, including both vestibular and cerebellar motor control, as well as the influences of the parietal and frontal lobes. Diagnostic methods include genetic evaluation, electrodiagnosis, pathology, and brain imaging. Neuromuscular disorders of both children and adults will be included. - Identifies normal motor control physiology and function, including neuroanatomy, circuits, and synapses - Discusses vestibular and cerebral motor control and contributions of parietal and frontal lobes - Provides diagnostic methods, including genetic evaluation, electrodiagnosis, brain imaging, and pathology analyses - Summarizes the diagnosis, course, and best practice treatment of neuromuscular disorders - Explores neuromuscular disorders in adults and children

This comprehensive review of research and best practice clinical management of spinal cord, neurodegenerative, and cerebral disorders is intended for both researchers and clinicians. Encompassing hereditary and acquired disorders from disease and accident, the book explores motor control disorders associated with stroke, dementia, seizure, encephalitis, and more. Covering disorders of both children and adults, the book discusses the latest advances in treatments related to neuroplasticity, neural tissue transplantation, and immunotherapy. - Summarizes assessment, disease course, and best practice treatment - Includes hereditary disorders and disorders from disease or accident - Discusses advances in neuroplasticity, tissue transplantation, immunotherapy, and other treatments - Reviews effects of dementia, stroke, seizure, encephalitis, cancer, and more

This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. - Profiles paraneoplastic diseases by tumor type - Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis - Presents individual syndromes of the CNS, PNS, NMJ, and muscle - Investigates the role of antibody markers - Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities - Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS - Reviews therapeutic strategies and clinical approach to PNS patients

Inherited White Matter Disorders and Their Mimics, Volume 204 discusses where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes and genetic disorders (the leukodystrophies and genetic leukoencephalopathies) often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. This book brings together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping. This volume presents both common WMDs and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable. - Includes common and rare white matter disorders (WMDs) - Summarizes advances in genetics, radiology, and treatments for WMDs - Provides clinical and radiological phenotyping - Contains imaging, diagnostic algorithms, and guidance on treatment

A rehabilitation text on intervention for body image and perceptual disturbances as they relate to activities of daily living. It addresses this type of performance dysfunction as it is manifested across the many diagnostic groups typically treated by rehabilitation specialists.