The second edition of Neurobiology of Disease includes nearly 200 articles surveying all major disorders of the nervous system in both adults and children, focusing on relevant diagnosis and treatments from the perspective of cutting edge clinical and basic neurobiological research. Akin to an encyclopedia of every neurologic disorder, this comprehensive work is ideal for graduate and medical school students, residents, and candidates preparing for their board certification examinations. Each chapter is illustrated with detailed figures, supplemented with descriptive and diagnostic tables, and thoroughly referenced for further investigations. The book's editors, Michael V. Johnston, Harold P. Adams Jr., and Ali Fatemi bring their unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this new edition, the following Section Editors provided oversight of their respective sections: · Movement Disorders-Joel Perlmutter, Washington University · Dementias-David Knopman, Mayo Clinic · Motorneuron Diseases-Merit Cudkowicz, Massachusetts General Hospital · Paroxysmal Disorders-Solomon Moshe, Albert Einstein College of Medicine · Pediatric Neurology and Developmental Disorders-Tanjala Gipson and Deepa Menon, Kennedy Krieger Institute and Johns Hopkins University · Neuroimmunological Diseases-Carlos Pardo-Villamizar, Johns Hopkins University · Cerebrovascular Diseases-Harold P. Adams Jr., University of Iowa · Peripheral and Autonomic Nervous System Disorders and Pain-Nicholas Maragakis, Johns Hopkins University · Neoplastic and Paraneoplastic Diseases-Lisa DeAngelis, Memorial Sloan-Kettering Cancer Center · Infectious Diseases of the Nervous System-Karen L. Roos, Indiana University · Sleep Disturbances-Mark Dyken, University of Iowa · Substance Abuse and Toxicology Disorders-Barry E. Kosofsky, Weill-Cornell University Medical Center · Neurologic Manifestations of Medical Disorders-John C. Probasco, Johns Hopkins University

Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields. - Provides cutting edge information about fundamental mechanisms underlying neurological diseases - Amply supplied with tables, illustrations and references - Includes supporting clinical information putting the mechanisms of disease into perspective

Neurobiology of the Epilepsies – From Epilepsy: A Comprehensive Textbook, 3rd Edition, provides a concise, up-to-date review of basic sciences and the latest research advances in epilepsy. Ideal for general neurologists and neurosurgeons, epilepsy/clinical neurophysiology specialists, basic scientists, clinical researchers, and other health care providers with an interest in epilepsy, this new volume by Drs. Istvan Mody, Hal Blumenfeld, Jerome Engel, Jr., Asla Ptkänen, Ivan Soltesz, and Annamaria Vezzani offers comprehensive, authoritative coverage of this critical and complex area of the field.

The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. Its recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical and neurocomputational literature that presents basic mechanisms, theoretical models and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented in current literature, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. The Clinical Neurobiology of the Hippocampus explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural and psychiatric symptoms and surpasses the ability to encode, store and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia. The first part of the book covers the basic and integrative features of the hippocampus, such as the anatomy and imaging of this structure, and the basic mechanisms of hippocampal function, including the principles of hippocampus-dependent memory processing in amnesia and sleep, the mechanisms of vulnerability and adult neurogenesis as well as the effects of stress. The second part covers the various clinical manifestations in which the hippocampus is involved and in which the preceding basic mechanisms are reflected. Bringing together a broad team of experts on the basic and clinical aspects of the hippocampus, the book provides an integrative view of the hippocampus. It is invaluable for neurologists, neuroscientists, and psychiatrists, and will stimulate interdisciplinary discussions in clinical neuroscience.

Organized to approach patient problems the way you do, this best-selling text guides you through the evaluation of neurologic symptoms, helps you select the most appropriate tests and interpret the findings, and assists you in effectively managing the underlying causes. Its practical approach makes it an ideal reference for clinical practice. Includes practical, evidence-based approaches from an internationally renowned team of authors. Zeroes in on what you really need to know with helpful tables that highlight links between neurological anatomy, diagnostic studies, and therapeutic procedures. Offers a logical, clinically relevant format so you can find the answers you need quickly. Features a new, updated design for easier reference. Includes new full-color images and updated illustrations to facilitate comprehension of important concepts. Features updated chapters on the latest genetic- and immunologic-based therapies, advances in pharmacology, and new imaging techniques. Includes an expanded and updated CD-ROM that allows you to view video clips of patient examinations, download all of the book's illustrations, and enhance exam preparation with review questions.

This comprehensive colour atlas provides a state-of-the-art view of Single Photon Emission Computerised Tomography (SPECT) in relation to its application in the fields of nuclear medicine and psychiatry. The broad range of topics covered by experts in the fields of nuclear medicine, neurology and psychiatry from all over the world, reflects the most recent evolution in functional neuroimaging with clinical neuropsychiatric sciences. The book is organised with respect to clinical indication, which implies that whenever possible methodological problems related to clinical indication are categorised under the relevant topic. It is designed to stimulate discussion of some issues of paramount importance for the present and future development of this interdisciplinary modality for the study of patients with diseases of the central nervous system. This textbook is an important tool to all nuclear physicians, neurologists and psychiatrists and will serve as a guide towards the optimal application of SPECT in diagnosis, study of pathophysiology and therapeutic follow-up in neuropsychiatric illnesses.

neurology A fully updated and authoritative neurology resource The Queen Square Textbook has established itself as a favourite companion to clinical neurosciences training and teaching around the world, whilst retaining its role as an invaluable reference guide for physicians and other healthcare professionals working in neurology, general medicine and related specialties. The book continues to reflect the core values essential to the practice of clinical neurology in the 21st century. The third edition has been extensively revised and updated to take account of the rapid pace of progress in the neurosciences and patient care. Contemporary neurology has been changed by the COVID-19 pandemic, the climate emergency and the growing inequalities in healthcare resources. The new edition has been extensively revised to reflect these challenges and affords a greater emphasis on management and rehabilitation whilst continuing to reflect the coherence of a text produced from a single, closely-knit, centre of excellence. Highlights of the new edition include: An updated approach to clinical examination, decision-making and diagnosis New developments in neuroimmunology, pathology and genetics Neuropalliative care Ethical and legal issues in clinical neurology The latest developments in the understanding and management of stroke, movement disorders, epilepsy, cognitive impairment, multiple sclerosis, infections, myelopathy, anterior horn cell disease, disorders of nerve and muscle, neuro-oncology, neurological disorders of hearing, balance and vision, and the neurological care of critical illness, sleep, neuropsychiatry, pain, autonomic and urological disorders. An emphasis on treatment and rehabilitation of the person with a neurological disease The new edition marks a significant transition to reflect contemporary neurological practice during uncertain times. It mirrors the enormous changes in investigation, diagnosis and treatment that have occurred in recent years whilst maintaining the underlying principle that we do not treat diagnoses but, rather, we care for people affected by neurological disease.

Unlike many other diagnostic procedures, EEG, now over 80 years old, and epilepsy monitoring, now over 40 years old, have demonstrated their usefulness and stood the test of time. Although the benefits of these diagnostic procedures are clear, monitoring is currently not available to the majority of patients in need. One of the factors limiting broader implementation is the lack of practitioners with special expertise. Epilepsy and Intensive Care Monitoring was developed to address this concern. This practical volume contains detailed chapters covering all areas of clinical epilepsy monitoring. Featuring expert authors from major epilepsy centers, this seminal work reviews all current procedures and applications for monitoring adults and children with epilepsy in the Epilepsy Monitoring Unit and the ICU. Opening sections are devoted to indications, procedures, administrative considerations, and technical aspects of the Epilepsy Monitoring Unit and ICU monitoring, followed by dedicated sections on EEG diagnosis and localization and monitoring of neurological disorders in the Epilepsy Monitoring Unit and ICU. The book concludes with special procedures and an Appendix with guidelines for organizing epilepsy monitoring centers and technical aspects of EEG monitoring. Key Features include Covers both adult and pediatric Epilepsy Monitoring Unit and ICU monitoring Contains over 235 high-quality EEGs and other illustrations, including an 8-page color section Comprehensive coverage; no other book in this area has comparable breadth and depth Clinical Focus Expert authors tell you when and how to perform the procedures they discuss

This is a clinical neurology book for the student, non neurologist, and those that teach them. The book covers neuroanatomy, history taking and examination and then proceeds to discuss the clinical features of common problems as well as some of the more common rare, neurological disorders, in a way that will demystify a part of medicine that students find complex and difficult to understand. The book is accompanied by a DVD explaining concepts, demonstrating techniques of performing the neurological examination and demonstration of abnormal neurological signs. The first chapter is devoted to neuroanatomy from a clinical viewpoint. The concept of localising problems by likening the nervous system to a map grid with vertical meridians of longitude (the ascending sensory pathways and the descending motor pathway)and horizontal parallels of latitude (cortical signs, brainstem cranial nerves, nerve roots and peripheral nerves) of the nervous system is developed. Subsequent chapters take the reader through the neurological examination and the common neurological presentations from a symptom oriented approach. Chapter 4 contains a very simple method of understanding the brainstem, the "rule of 4". Chapter 6 discusses the approach after the history and examination are completed. The final chapter is an overview of how to approach information gathering and keeping up-to-date using the complex information streams available. widely illustrated with case studies and illustrations key points clinical questions clinical orientation with comprehensive references

This Gold Standard in clinical child neurology presents the entire specialty in the most comprehensive, authoritative, and clearly written fashion. Its clinical focus, along with relevant science, throughout is directed at both the experienced clinician and the physician in training. New editor, Dr. Ferriero brings expertise in neonatal neurology to the Fourth Edition. New chapters: Pathophysiology of Hypoxic Ischemic Encephalopathy, Congenital Disorders of Glycosylation, Pediatric Neurotransmitter Diseases, Neurophysiology of Epilepsy, Genetics of Epilepsy, Pediatric Neurorehabilitation Medicine, Neuropsychopharmacology, Pain and Palliative Care Management, Ethical Issues in Child Neurology