This book comprises a collection of categorized case-based questions, directed and meticulously selected to cover the most common and most important aspects of immunodeficiency diseases. Immunodeficiency disorders of infancy and childhood such as antibody deficiencies, phagocyte defects and defects in innate immunity are addressed among others. Each chapters starts with a brief of the initial presentation and lab data of the patient, followed by a series of 5-6 multiple choice questions (MCQs), leading the reader to the diagnosis and best of practice in a step-wise manner. This MCQ format along with precise, yet detailed answer ensures a quick, case-based, reality learning to the reader. This comprehensive MCQ series, is an essential reading material that a pediatric clinician, hematologist, immunologist, transplant specialist, or pulmonologist, can not afford to miss.

Pediatric Immunology and Allergy, An Issue of Immunology and Allergy Clinics of North America, E-Book

Together with Consulting Editor Dr. Bonita Stanton, Dr. Elizabeth Secord has put together a comprehensive issue that discusses the updates in pediatric immunology and allergy. Expert authors have contributed clinical review articles on the following topics: Humoral Immune deficiency in childhood; Neutrophil deficiencies; Newborn screening for severe combined immune deficiency (SCID); New treatments for asthma; New insights and treatments in Atopic Dermatitis; Food allergy avoidance and treatments; Eosinophilic Esophagitis; Inner City Asthma; Allergic rhinitis; Anaphylaxis in children and adolescents; Biologic therapy induced immune deficiency; Drug Allergies and Sensitivities in children; and Secondary immune deficiency. Readers will come away with the information they need to improve outcomes in pediatric patients with immunologic and allergic conditions.

This Research Topic highlights high-quality Case Reports in Pediatric Immunology. Our Case Reports aim to highlight unique cases of patients that present with an unexpected/unusual diagnosis, treatment outcome, or clinical course. Case Reports provide insight into the differential diagnosis, decision making, and clinical management of unusual cases and are a valuable educational tool.

Easy to understand and easy to use, this essential book reflects the rapid progress in one of the most intriguing fields of medicine. It offers state-of-the-art information on basic immunology, fetal-neonatal immunology, and many more fascinating areas.

Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pediatric and Adolescent Medicine Research and Practice. The editors have built Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pediatric and Adolescent Medicine Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Special Volume 22 of Recent Advances in Pediatrics is a compilation of reviews bringing trainees and physicians fully up to date with key developments in paediatric immunology, infections and immunisation. Divided into four sections, Part 1 discusses issues and concerns in immunology, immunodeficiency and immunotherapy. Part 2 examines infections that may be encountered in children, including HIV, tuberculosis and meningococcal disease. Parts 3 and 4 cover immunisation and pharmacotherapy. Presented in an easy to follow format, Special Volume 22 follows a multidisciplinary approach. Each chapter finishes with a summary of key learning points and extensive references for further reading. Clinical photographs, illustrations and tables enhance learning. Key points New, updated volume presenting latest developments in paediatric immunology, infections and immunisation Multidisciplinary approach, easy to follow format Extensive references and key learning points summarised in each chapter Includes contributions from experts in London, Liverpool and New York

Issues in Pediatric and Adolescent Medicine Research and Practice: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pediatric Surgery. The editors have built Issues in Pediatric and Adolescent Medicine Research and Practice: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pediatric Surgery in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pediatric and Adolescent Medicine Research and Practice: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma.