The definitive reference work on the developing brain from conception through the first year of life, this book provides specialists involved in the management of the fetus and the neonate with the latest information on the developmental neurology and pathology of the developing central nervous system.

Provides the insights in neonatal neurology. This title describes from the discoveries in genetics through the advances in the diagnosis and management of neurologic disorders. It delivers clinical guidance you need to provide effective care for neonates with neurological conditions.

This book constitutes the refereed proceedings of the First International Workshop on Perinatal, Preterm and Paediatric Image Analysis, PIPPI 2022, held in conjunction with the 25th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2022, in Singapore, Singapore, in September 2021. The 10 full papers and 1 short papers presented at PIPPI 2022 were carefully reviewed and selected from 12 submissions. PIPPI 2022 workshop complements the main MICCAI conference by providing a focused discussion of perinatal and paediatric image analysis, including the application of sophisticated analysis tools to fetal, neonatal and paediatric imaging data.

The novel aim of this book is to illustrate the MR imaging features of the fetal and the neonatal brain by matching prenatal and postnatal images for a wide range of neurological abnormalities. The focus is on both conventional and advanced MR imaging techniques, including high-resolution MR autopsy of the fetal brain. During the past ten years, neuroradiological evaluation of the neonatal and the prenatal brain has advanced tremendously. However, even though they are intrinsically related, these two critical stages in brain development are usually studied and presented separately. In order to have a sound understanding of neonatal brain diseases, detailed knowledge of prenatal brain pathology is immensely helpful; conversely, knowledge of neonatal brain disease is a prerequisite for understanding many fetal brain lesions. Written by experts in the field, Perinatal Neuroradiology will be of value for neuroradiologists and pediatric radiologists, as well as obstetricians and neonatologists.

This volume is based on a highly successful conference dedicated to “Perinatal brain damage:from pathogenesis to neuroprotection ”. Neonatologists, paediatricians, paediatric neurologists, obstetricians, basic researchers involved in neurosciences, as well as rehabilitation professionals, will be interested by this ensuing publication. The volume covers pathogenic aspects of brain lesions occurring in the fetal and neonatal period, and addresses the issues of diagnostic workup and treatment.The most authoritative basic researchers, clinicians, and specialists in the field of neuroimaging, provide chapters on recent clinical advances. A subject of particular importance is the neurological vulnerability of the preterm infant, which also touches on ethical aspects of the care of high-risk preterm babies and those born from multiple pregnancies. A particularly original session focuses on cerebral white matter and the many issues related to this crucial part of the developing brain. Experts also deal with cerebral visual impairment, motor development, cognitive function, and the mechanisms underlying the neuronal plasticity of the infant’s brain. Concepts of neuroprotection are also outlined, based on pharmacological agents tested on experimental animals and the best drugs used to treat neonatal convulsions.

Innovations in technology and new therapies have changed the face of medicine in the last few decades. These include advances in fetal diagnosis (preimplantation genetics, chorionic villous sampling and amniocentesis), drugs that have been developed to treat unique conditions in neonates such as respiratory distress syndrome (surfactant) and pulmonary hypertension (inhaled nitric oxide), as well as technological advances and interventions resulting in diagnostic (ultrasounds and MRI) and therapeutic interventions (intrauterine transfusion to ECMO). Research in fertility treatments has resulted in test tube babies and cloned animals, and that has also fostered technological advances in diagnostic and therapeutic interventions.The primary purpose of Innovations in Neonatal-Perinatal Medicine is to highlight these innovations in technology and therapy that have not only changed the way doctors deliver care to fetus and neonate but also reduced neonatal mortality thereby saving millions of lives in the process. These issues are addressed by the authors who are experts in their respective fields. The book will be valuable not only to healthcare providers but also to educators and policy makers.

This book constitutes the proceedings of the First International Workshop on Advances in Simplifying Medical UltraSound, ASMUS 2020, and the 5th International Workshop on Perinatal, Preterm and Paediatric Image Analysis, PIPPI 2020, held in conjunction with MICCAI 2020, the 23rd International Conference on Medical Image Computing and Computer-Assisted Intervention. The conference was planned to take place in Lima, Peru, but changed to an online event due to the Coronavirus pandemic. For ASMUS 2020, 19 contributions were accepted from 26 submissions; the 14 contributions from the PIPPI workshop were carefully reviewed and selected from 21 submissions. The papers were organized in topical sections named: diagnosis and measurement; segmentation, captioning and enhancement; localisation and guidance; robotics and skill assessment, and PIPPI 2020.