Topic Editor Prof. Lennart Hammarström holds equity in ImmunoIVD. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

This issue of Immunology and Allergy Clinics of North America, Guest Edited by Dr. Lisa Kobrynski, is devoted to Primary Immune Deficiencies. Articles in this issue include: Personalized therapy: Immunoglobulin replacement for antibody deficiency; Newborn Screening for Severe Combined Immunodeficiency: Update on newborn screening and lessons learned; Update on Advances in Hematopoietic Cell Transplantation for Primary Immunodeficiency Disorders; Hereditary Autoinflammatory Disorders: Recognition and treatment of inflammatory disorders of the immune system; Use of Immunomodulatory Agents to Treat Primary Immune Deficiencies: Mechanism-based therapy; Secondary Hypogammaglobulinemia: An increasingly recognized complication of treatment with immunomodulators and post-solid organ transplantation; Use of Vaccines in Primary Immunodeficiency; Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders; Hyper IgE Syndromes; Early Onset Inflammatory Bowel Disease; and Genome Testing to Diagnose Primary Immunodeficiency Disorders and to Identify Targeted Therapy.

This book is a comprehensive guide to the diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns. Divided into eight sections, the text begins with detailed discussion on foetal haematology, antenatal diagnosis of disorders, red blood cell disorders and anaemia in the newborn, and coagulation and platelet conditions. The following chapters cover foetal and neonatal malignancies and blood transfusion, followed by a final section on immunological disorders. Each topic explains new advances, all current treatment protocols, new drugs, and management approaches. Chapters are further enhanced by clinical images and tables. Key points Comprehensive guide to diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns Presented in an easy to follow format, explaining new advances, treatment protocols, new drugs, and management approaches Includes discussion on neonatal malignancies and blood transfusion Highly illustrated with clinical images and tables

**Selected for Doody's Core Titles® 2024 in Pediatrics**A must-have reference for both general physicians and advanced practice providers, Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant provides trusted, time-tested guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. The fully revised 12th Edition is an ideal resource for every stage of practice and remains the most comprehensive, multidisciplinary text in the field. Drs. Richard J. Martin and Avroy A. Fanaroff from Rainbow Babies and Children's Hospital bring you up to date with everything from diagnosis and treatment selection through post-treatment strategies and management of complications—all with a dual focus on neonatology and perinatology, and all designed to help you improve the quality of life and long-term outcomes of your patients. - Provides up-to-date, evidence-based content throughout, including state-of-the-art coverage of personalized medicine and genetics. - Contains new chapters on Big Data for the Smallest Patients: What we can learn from neonatal database research; Role of Umbilical Cord Management in Neonatal Resuscitation; Care of Periviable Micropremies: the Japanese perspective; Longer Term Respiratory Outcomes of Prematurity; and Perinatal Palliative Care. - Features extensive updates throughout, including blood and the hematopoietic system; social and economic contributors to neonatal outcome; fetal growth restriction; diagnostic imaging of the neonate; anesthesia in the neonate; postnatal bacterial infections; neonatal management of congenital heart disease; and retinopathy of prematurity. - Includes over 600 detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. - Provides indexing in both volumes that provides quick access to specific guidance. - Offers a global perspective with an expanded number of international contributors. - An ideal resource for clinical practice as well as recommended reading for neonatology board review or maintenance of certification. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.

This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases.