The purpose of this book is to review and critically evaluate the best new methods to synthesize alpha-amino acids in optically active form. There is so much new literature on amino acid synthesis that the experimentalist will undoubtedly have difficulty in selecting the most appropriate methodology for constructing the amino acid of immediate interest. This book is a guide for steering the scientist through the maze of existing reports on the subject and contains the most up-to-date critical reviews of methods of asymmetric synthesis of amino acids. In areas that are relatively new conceptually and less studied experimentally, an effort has been made to review the most salient works with an eye towards future development. Over 330 schemes and figures are presented with references for rapid visual retrieval of information. The book will be of great value to academic and industrial organic research chemists, especially those concerned with medicinal and agricultural chemistry, as well as to graduate and post graduate students, biochemists and biologists.

The purpose of this book is to review and critically evaluate the best new methods to synthesize alpha-amino acids in optically active form. There is so much new literature on amino acid synthesis that the experimentalist will undoubtedly have difficulty in selecting the most appropriate methodology for constructing the amino acid of immediate interest. This book is a guide for steering the scientist through the maze of existing reports on the subject and contains the most up-to-date critical reviews of methods of asymmetric synthesis of amino acids. In areas that are relatively new conceptually and less studied experimentally, an effort has been made to review the most salient works with an eye towards future development. Over 330 schemes and figures are presented with references for rapid visual retrieval of information. The book will be of great value to academic and industrial organic research chemists, especially those concerned with medicinal and agricultural chemistry, as well as to graduate and post graduate students, biochemists and biologists.

Imides: Medicinal, Agricultural, Synthetic Applications and Natural Products Chemistry provides a comprehensive overview of imides being developed as pharmaceuticals or experimental therapeutics. Featuring a diverse range of experts in the field of imides, each chapter reviews the state-of-the-art, including the isolation and identification of naturally-occurring imides, as well as the total synthesis of imide natural products. As there is a need for a comprehensive review of imides as a class of naturally-occurring, biologically active molecules, this book will be invaluable to those in pharmaceuticals, academia, and anyone looking for clinical applications. - Features cutting-edge research in the field of imides for pharmaceutical and experimental therapeutic applications - Includes coverage of naturally occurring imides, along with medicinal chemistry-inspired imides - Focuses on the presentation of selected targets for their complex multistep synthesis - Discusses new reagents and strategies for synthesis - Includes contributions from leading experts in the field of imide research, working in both natural product chemistry and medicinal chemistry

This book covers the remarkable development of the chemistry and applications of Mannich bases within the last 30 years. It provides an updated and comprehensive look at these compounds-compounds identified at the beginning of the century. Particular emphasis is placed on the versatile chemistry of Mannich bases. Synthesis and reactions of Mannich bases are systematically treated in the first two chapters, which include a thorough review of the most recent advances on the topic. Chapters 3 and 4 are devoted to the macromolecular chemistry and the chemistry of natural compounds, two emerging areas of application of the chemistry of Mannich bases. Chapter 5 deals with structure/property relationships that enable the production of tailor-made molecular structures suited to different practical applications. A survey of the main uses of individual Mannich bases according to the type of industrial branch is also reported.

Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.

As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook fir

Due to their medicinal activity and potential use as synthetic starting materials, studies on beta-lactams have increased significantly. This unique volume takes readers on a tour de force from the concept of antibiosis to the serendipity of antibiotics, evolution of beta‐lactam development, and molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. Considerable work has been performed by chemists and biologists to continue updating their findings about beta-lactam synthesis. Features: • Stereoselective synthesis of monocyclic, bicyclic, and polycyclic beta-lactams • Microwave, ultrasound, and solid support-mediated preparation of beta-lactams • Diverse medicinal activities including anticancer activities of beta-lactams and products obtained from them • Nanoparticles, artificial intelligence, and dipole moments in beta-lactam science • Synthesis and mechanism of formation of polyaromatic beta-lactams

This Volume, which is in three parts, includes some of the most important functional groups of organic chemistry. Part I deals with the synthesis of carboxylic acids and their derivatives (acid halides, esters, amides etc.) together with their imino-, thio-, seleno and telluro analogues. Part II covers cumulenes such as isocyanates, isothiocyanates, carbodiimides and related compounds, whilst Part III deals with triply bonded functional groups.