Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

A human being consists of a mammalian component and a multiplicity of microbes, collectively referred to as the "microbiota" or "microbiome," with which it has a symbiotic relationship. The microbiota is comprised of a variety of communities, the composition of each being dependent on the body site it inhabits. This community variation arises because the numerous locations on a human being provide very different environments, each of which favors the establishment of a distinct microbial community. Each community consists of bacteria, fungi and viruses with, in some cases, archaea and/or protozoa. It is increasingly being recognized that the indigenous microbiota plays an important role in maintaining the health of its human host. However, changes in the overall composition of a microbial community at a body site, or an increase in the proportion of a particular species in that community, can result in disease or other adverse consequences for the host. The Human Microbiota in Health and Disease: An Ecological and Community-Based Approach describes the nature of the various communities inhabiting humans as well as the important roles they play in human health and disease. It discusses techniques used to determine microbial community composition and features a chapter devoted to the many factors that underlie this mammalian–microbe symbiosis. Uniquely, the book adopts an ecological approach to examining the microbial community’s composition at a particular body site and why certain factors can shift a community from a eubiotic to a dysbiotic state. The book is for undergraduates and postgraduates on courses with a module on the indigenous microbiota of humans. It will also be useful to scientists, clinicians, and others seeking information on the human microbiota and its role in health and disease.

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

This book comprehensively covers the microbiome in respiratory disease, from the initial research study to the disease-specific implications and related applications. Research on the respiratory microbiome is increasing in volume and scope. This reflects rapidly growing interest in the study of respiratory disease to understand how microbiota shape mechanisms of disease pathogenesis. The respiratory tract spans the nasal passages, sinus cavities, oropharynx, and the tracheobronchial tree of the lungs. In these compartments of the upper and lower respiratory tract, the microbiota have now been studied in the context of several chronic respiratory conditions. These include chronic sinusitis, allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and pulmonary fibrosis, to name a few. The potential impact of ecological interactions (i.e., between microbes and between microbiota and host) within and across respiratory compartments is increasingly recognized. The book is organized into two main sections. Part I, Principles and Tools, covers conceptual modeling of the respiratory microbiome, experimental methodology with a focus on a priori considerations in study design and sampling, laboratory and computational methods for analysis of respiratory microbiome data, and minimizing interpretive pitfalls. Part II, Applications, discusses the evidence from specific studies that have shed novel insights into the influence of respiratory microbiota on mechanisms or outcomes in specific diseases. Based on current best evidence, disease-specific chapters include chronic rhinosinusitis, asthma (pediatric and adult studies), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis not due to CF, idiopathic pulmonary fibrosis, and lung transplant. This is an ideal reference for forward-thinking practitioners with interest in novel developments in precision medicine applications in lung disease, as well as translational scientists in the field of microbiology, immunology and lung biology.

A medical research pioneer reveals “how food choices that support biodiversity can save lives, shield us from novel infections, and protect the planet” (Joel Fuhrman, MD, #1 New York Times–bestselling author of Eat to Live). In his acclaimed book The Mind-Gut Connection, physician, UCLA professor, and researcher Dr. Emeran Mayer offered groundbreaking evidence of the critical role of the microbiome in neurological and cognitive health, proving once and for all the power and legitimacy of the “mind-body connection.” Now, in The Gut-Immune Connection, Dr. Mayer proposes an even more radical paradigm shift: that the gut microbiome is at the center of virtually every disease that defines our twenty-first-century public health crisis. Cutting-edge research is advancing our understanding of the function and impact of the billions of organisms that live in the GI tract, and in Dr. Mayer’s own research, he has amassed evidence that the “conversation” that takes place between these microbes and our various organs and bodily systems is critical to human health. When that conversation goes awry, we suffer, often becoming seriously ill. Combining clinical experience with up-to-the-minute science, The Gut-Immune Connection offers a comprehensive look at the link between alterations to the gut microbiome and the development of chronic diseases like diabetes, heart disease, and cancer, as well as susceptibility to infectious diseases like Covid-19. Dr. Mayer argues that it’s essential we understand the profound and far-reaching effects of gut health and offers clear-cut strategies to reverse the steady rise of these illnesses, including a model for nutrition to support the microbiome. But time is running out: A plague of antimicrobial resistance is only a few decades away if we don’t make critical changes to our food supply, including returning to sustainable practices that maintain the microbial diversity of the soil. To turn the tide of chronic and infectious disease tomorrow, we must shift the way we live today.

More than 125 gut-friendly recipes plus science-backed advice for wellness in body and mind This game-changing cookbook will make you rethink how you eat. It turns out that gut health is the root of all health: A happy equilibrium in the body’s unique community of microbes promotes good health throughout the body, including a stronger immune system, better sleep, and lower stress. Despite eating healthfully, author and recipe developer Lindsay Maitland Hunt was plagued by symptoms such as depression, fatigue, incessant itching, and joint pain—until a gut-friendly way of eating helped bring her back to a state of balance. In fact, she felt better than ever before. Out of Lindsay’s journey from sickness to health, and her extensive research, comes this practical and nourishing guide, with irresistibly delicious recipes that make you feel good too. Dishes emphasize plant-based ingredients like vegetables, nuts and seeds, beans and legumes, and whole grains, along with eggs, fish, and some meat and dairy, if you like. Lindsay also walks you through integrating fermented foods into your daily life and reducing added sugar and processed foods. It’s an approach you can tailor to your own lifestyle, whether you’re vegan, gluten free, or just love to eat! Recipes cover any time you eat, from quick weeknight dinners to party-worthy treats, including: Seeded Almond Flour Waffles with Raspberry-Flax Smash Garlicky Shrimp and Quinoa “Grits” Special-Occasion Short Ribs with Olive Oil and Kefir Mashed Potatoes Parsley, Kale, and Pumpkin Seed Pesto Brussels Sprouts and Peanut Butter Curry Bowl Peanut Butter–Banana “Nice” Cream Plus go-to essentials (roasted vegetables, simply cooked leafy greens, sprouted grains, and more) for building meals off the cuff Beyond the recipes, Lindsay explains what you need to know about your gut microbiota and offers smart strategies and solutions to help you navigate real life, like a new food pyramid for gut health and tips for tracking (and rewarding) healthy-living habits. Help Yourself isn’t a fad diet, a detox, or a cleanse. It’s a common-sense approach to food, backed by science. If you’ve been living with symptoms such as allergies, chronic pain, inflammation, bloating or weight gain, exhaustion or poor sleep, acne, irritability, if you’ve been diagnosed with an autoimmune disease—or if you just want to feel your best in your body—this book offers a pathway to wellness via the gut.

Cutting-edge neuroscience combines with the latest discoveries on the human microbiome to inform this practical guide that proves once and for all the inextricable, biological link between mind and body. We have all experienced the connection between our mind and our gut—the decision we made because it “felt right;” the butterflies in our stomach before a big meeting; the anxious stomach rumbling when we’re stressed out. While the dialogue between the gut and the brain has been recognized by ancient healing traditions, including Aryuvedic and Chinese medicine, Western medicine has failed to appreciate the complexity of how the brain, gut, and more recently, the microbiome—the microorganisms that live inside us—communicate with one another. In The Mind-Gut Connection, Dr. Emeran Mayer, Executive Director of the UCLA Center for Neurobiology of Stress, offers a revolutionary look at this developing science, teaching us how to harness the power of the mind-gut connection to take charge of our health. The Mind-Gut Connection, shows how to keep the communication brain-gut communication clear and balanced to: • Heal the gut by focusing on a plant-based diet • Balance the microbiome by consuming fermented foods and probiotics, fasting, and cutting out sugar and processed foods • Promote weight loss by detoxifying and creating a healthy digestion and maximum nutrient absorption • Boost immunity and prevent the onset of neurological diseases such as Parkinson’s and Alzheimer’s • Generate a happier mindset and reduce fatigue, moodiness, anxiety, and depression • Prevent and heal GI disorders such as leaky gut syndrome; food sensitivities and allergies; and IBS; as well as digestive discomfort such as heartburn and bloating • And much more. Supplemental enhancement PDF accompanies the audiobook.

Now in full color, the #1 text spanning the fields of public health and preventive medicine brings you fully up to date on the issues and topics you need to know A Doody's Core Title for 2023! Maxcy-Rosenau-Last Public Health and Preventive Medicine has been updated and revised for the first time in more than a decade. This highly anticipated and extensive edition provides the most current information and insights available on evidence-based public health and preventive medicine, from basic methodologies of public health to principles of epidemiology and infection control to environmental toxicology to global health. The most comprehensive resource of its kind, Maxcy-Rosenau-Last Public Health and Preventive Medicine is the clear choice for anyone seeking a career in public health. Features: • Edited and written by a who's who of global experts • 384 photos and illustrations • New full-color format and improved artwork • Significantly expanded coverage of diseases and preventive methods common in international markets • Greater use of tables and summary lists for easier reading and retention

Optimize your overall health through digestive wellness! Fewer antacids and less bloating aren’t the only benefits of good digestion. When your digestive system is healthy and balanced, you sleep better, have more energy, think more clearly, experience less pain, and combat disease more effectively. Digestive Health shows how everything from migraines to skin disease to arthritis are connected to your digestive system. And now, this go-to guide has been updated with critical new research and developments, including late-breaking information on: • Probiotics and Prebiotics • Celiac Disease • The Gut-Brain Connection • Carbohydrates • Leaky Gut Syndrome • Auto-Immune Conditions • Kidney and Bone Health • Cancer Prevention • Alzheimer’s Disease You’ll find practical solutions to numerous conditions and disorders, along with expert guidance on the newest advances in testing and diagnosis, nutrition, and natural therapies. A perfect balance of science and practical advice, Digestive Health explains how your digestive system works and what to do when it doesn’t function properly. It provides everything you need to take control of your overall health through close, careful attention to your digestive system.

Following the success of the bestselling Clean Gut and Wheat Belly comes this essential guide to improving digestive health from an expert in functional medicine—who reveals why everything that ails us, from fatigue to weight gain to bloating and bad skin, can be traced back to the gut, and shares his cleansing plan to help us reclaim our health. Dr. Vincent Pedre understands gut problems firsthand. He suffered from IBS for years before becoming an expert in functional medicine and learning how to heal his body from the inside. Dr. Pedre used his own experience to develop The Gut C.A.R.E. Program—an approach that draws from both Western and Eastern methodologies, combining integrative and functional medicine—that has a proven success record in his private practice in New York. Now, for the first time, Dr. Pedre makes his revolutionary plan for health and wellness available to everyone. Happy Gut takes readers step-by-step through Gut C.A.R.E.—Cleanse, Activate, Restore, and Enhance—which eliminates food triggers, clears the gut of unfriendly pathogens, and replaces them with healthy probiotics and nutrients that repair and heal the gut. Rather than masking symptoms with medication, he shows us how to address the problem at its core to restore the gastrointestinal system to its proper functioning state. By fixing problems in the gut, followers of Dr. Pedre’s program have found that their other health woes are also cured and have lost weight, gained energy, and improved seemingly unrelated issues, such as seasonal allergies, in addition to eliminating their chronic muscle and abdominal pain. Complete with recipes and meal plans including gluten-free, low-fat, and vegetarian options, a 28-day gut cleanse, yoga postures to help digestion, and testimonials from many of his patients, Happy Gut will help you feel better and eliminate gut issues for life.