Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting – cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation–related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging. - Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research - Describes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity - Defines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation - Makes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response - Explains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory - Contains color figures and tables that explain the field to newcomers

Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. - Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn's Disease and Ulcerative Colitis - Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures - Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn's Disease and Ulcerative Colitis - Contains access to videos demonstrating important procedural concepts

Thoroughly revised and updated, the 7th Edition of Rheumatology remains a leading text in this fast-changing field, keeping you abreast of recent advances in medications, therapies, clinical trials, and much more. Dr. Mark Hochberg and his team of expert authors and editors cover everything you need to know -- from basic scientific principles to practical clinical management strategies, all in a user-friendly, accessible manner. Provides access to quick, concise videos depicting musculoskeletal ultrasound including anisotropy, "comet tail" needle artifact, rheumatoid arthritis synovitis, acute gout, and more. Uses a consistent, logical, reader-friendly format with templated content and large-scale images for efficient visual reference. Features 14 completely new chapters covering biomedical and translational science, disease and outcome assessment, including new imaging modalities and early emerging disease, clinical therapeutics, and patient management and rehabilitation. Includes updated content on the latest diagnostic perspectives and approaches to therapy including tapering down of treatment, pulmonary hypertension and scleroderma, psoriatic arthritis, and the latest oral anticoagulants. Covers hot topics such as pathogenesis and pathophysiology of axial spondyloarthritis, DXA and measurement of bone, infectious arthritis, and more. Shares the knowledge and expertise of internationally recognized rheumatoid arthritis expert and new editor, Dr. Ellen Gravallese. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This second volume is dedicated to basic pathologies of the two most common osteoarticular diseases affecting large segments of the Western population, osteoarthritis and chondrodysplasias. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage biology and pathobiology.

NEW YORK TIMES BESTSELLER • Reset your metabolism for lasting fat loss in one month and discover the carbs that are right for you. The surprising truth is that we are genetically wired to eat more and move less, the exact opposite of the advice we are often given. Now there is a more customized weight loss solution that works with your body, a solution based not on arbitrary restriction of foods but on what works for YOU. Developed by former research biochemist, health expert, and bestselling author Robb Wolf, Wired to Eat offers an eating program, based on groundbreaking research, that will rewire your appetite for weight loss and help you finally determine the optimal foods for your diet and metabolism. With his bestselling book, The Paleo Solution, Robb Wolf helped hundreds of thousands of people lose weight by eating a low-carb Paleo diet, but Paleo is only a starting point, not a destination. Now, he'll share a more customized way of eating that may be the key to permanent weight loss and better health. You'll start with Wolf’s 30-Day Reset to help you restore your body's blood sugar levels, repair your appetite, and reverse insulin resistance. There are more than 70 delicious recipes, detailed meal plans, and shopping lists to aid you on your journey. Wolf also includes meal plans for people who suffer with autoimmune diseases, as well as advice on eating a ketogenic diet. Once you've completed this phase of the plan, the unique 7-Day Carb Test will help you determine what amounts and types of carbs you can tolerate. No more guessing. Now you can find out for yourself which foods you can and cannot eat, instead of relying on a one-size-fits all diet. Transform your diet by discovering your peronalized weight loss blueprint with Wired to Eat.

This book provides an alternative viewpoint towards classification of systemic pathophysiology. There is a recurring theme, i.e. Embryonic origin and the neuroendocrine basis of disease classification. Pathologies have been classified into inflammatory and degenerative, alpha and beta adrenergic inflammation, pre and postganglionic congenital defect. Hopefully it will complement the current classification of disease and yield a more complete picture of the disease to the reader. The first three chapters form the crux of the book, followed by systemwise examples of diseases in subsequent chapters. An exclusive chapter on nervi vasorum and the neuroendocrine basis of classification of vascular diseases is the highlight of the book.

Humanising Mental Health Care in Australia is a unique and innovative contribution to the healthcare literature that outlines the trauma-informed approaches necessary to provide a more compassionate model of care for those who suffer with mental illness. The impact of abuse and trauma is frequently overlooked in this population, to the detriment of both individual and society. This work highlights the importance of recognising such a history and responding humanely. The book explores the trauma-informed perspective across four sections. The first outlines theory, constructs and effects of abuse and trauma. The second section addresses the effects of abuse and trauma on specific populations. The third section outlines a diverse range of individual treatment approaches. The final section takes a broader perspective, examining the importance of culture and training as well as the organisation and delivery of services. Written in an accessible style by a diverse group of national and international experts, Humanising Mental Health Care in Australia is an invaluable resource for mental health clinicians, the community managed and primary health sectors, policy makers and researchers, and will be a helpful reference for people who have experienced trauma and those who care for them.

The second edition of Dentist's Guide to Medical Conditions, Medications and Complications continues to provide quick-access, clinical information on the dental treatment of patients with common systemic conditions and medical complications. Expanded in this second edition is information about patient medications. Ideal for general practitioners and students in advanced general dentistry programs, the book outlines protocols for treating patients with common conditions, presents essential drug interaction information, and guides the dental professional through prevention and management of in-office medical emergencies.