The acclaimed author of Thoughts of God, Michael Kanaly, once again probes the universe and the human experience in this story of a research scientist on the verge of an extraordinary discovery: certain virus clans are about to make themselves quite at home. To be perfect hosts, human beings will have to be changed...

Digital Contagions is the first book to offer a comprehensive and critical analysis of the culture and history of the computer virus phenomenon. The book maps the anomalies of network culture from the angles of security concerns, the biopolitics of digital systems, and the aspirations for artificial life in software. The genealogy of network culture is approached from the standpoint of accidents that are endemic to the digital media ecology. Viruses, worms, and other software objects are not, then, seen merely from the perspective of anti-virus research or practical security concerns, but as cultural and historical expressions that traverse a non-linear field from fiction to technical media, from net art to politics of software. Jussi Parikka mobilizes an extensive array of source materials and intertwines them with an inventive new materialist cultural analysis. Digital Contagions draws from the cultural theories of Gilles Deleuze and Félix Guattari, Friedrich Kittler, and Paul Virilio, among others, and offers novel insights into historical media analysis.

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. - The only comprehensive book on proteolytic enzymes - Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research - Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases - Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features - Over 1000 peptidases included

Brimming with fascinating and fun facts about 100 scientific breakthroughs, this collection presents the real stories behind the history of science, at the same time offering a panoramic overview of the history of science and an introduction to some of the most important scientists in history. Grades 6 and up. Throughout history, science has changed lives and dramatically altered the way in which the universe is perceived. Focusing on the 100 most significant scientific events of all time—from Archimedes' discovery of the two fundamental principles underlying physics and engineering (levers and buoyancy) in 260 B.C.E. to human anatomy, Jupiter's moons, electrons, black holes, the human genome, and more—storyteller Kendall Haven has created a ready reference for those seeking information on science discoveries.

The proteolytic enzymes have an essential function in all cells. Their activities are regulated by the rate of synthesis, activation of proenzymes and by the rate of synthesis of their inhibitors. They are synthesized in ribosomes like any other proteins and transported to various storage organelles or secreted from the cells and are activated in the pericellular space or in interstitium. Various cells and tissues have their characteristic enzyme patterns which serve their specific functions. Proteolytic enzymes take part and often have a regulatory role in numerous phases of cell function, e.g. cell division, migration, apoptotic as well as necrotic cell death etc. Diseases in which proteolysis has been subject of active research are e.g. cancer metastasis, viral infections, e.g. HIV, and Alzheimer's disease. They are also an essential part in any tissue remodelling, wound healing, throughout the kingdom of fauna and flora.

Contributions by Malin Alkestrand, Joshua Yu Burnett, Sean P. Connors, Jill Coste, Meghan Gilbert-Hickey, Miranda A. Green-Barteet, Sierra Hale, Kathryn Strong Hansen, Elizabeth Ho, Esther L. Jones, Sarah Olutola, Alex Polish, Zara Rix, Susan Tan, and Roberta Seelinger Trites Race in Young Adult Speculative Fiction offers a sustained analysis of race and representation in young adult speculative fiction (YASF). The collection considers how characters of color are represented in YASF, how they contribute to and participate in speculative worlds, how race affects or influences the structures of speculative worlds, and how race and racial ideologies are implicated in YASF. This collection also examines how race and racism are discussed in YASF or if, indeed, race and racism are discussed at all. Essays explore such notable and popular works as the Divergent series, The Red Queen, The Lunar Chronicles, and the Infernal Devices trilogy. They consider the effects of colorblind ideology and postracialism on YASF, a genre that is often seen as progressive in its representation of adolescent protagonists. Simply put, colorblindness silences those who believe—and whose experiences demonstrate—that race and racism do continue to matter. In examining how some YASF texts normalize many of our social structures and hierarchies, this collection examines how race and racism are represented in the genre and considers how hierarchies of race are reinscribed in some texts and transgressed in others. Contributors point toward the potential of YASF to address and interrogate racial inequities in the contemporary West and beyond. They critique texts that fall short of this possibility, and they articulate ways in which readers and critics alike might nonetheless locate diversity within narratives. This is a collection troubled by the lingering emphasis on colorblindness in YASF, but it is also the work of scholars who love the genre and celebrate its progress toward inclusivity, and who further see in it an enduring future for intersectional identity.

This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.

'Clever and compelling' Luke Jennings 'Viral is a vicious delight' Sam Byers 'Nobody else could capture the tragedy, transience and absurdity of modern life quite like this' Andrew McMillan Meet Ned and Alice: internet entrepreneurs with a delightfully demagnetised moral compass. In Berlin, their combined talents have brought social media start-up, The Thing Factory, to the verge of lucrative success. But Ned - a businessman with a history of shady dealings - is unhappy at his increasing lack of control in the company. When he launches a new app designed to 'Uberize' the escort industry, he finds himself treading in murky waters, having disturbed the fabric of Berlin's underbelly. As his anxieties become harder to ignore, Alice's ambitions are meanwhile tempting her to jettison her own principles for a turn at the wheel... Both a satire on the social media age and a fast-paced suspense novel, Viral is a nimble commentary on power and control, the lengths people will go to acquire both, and what is at stake when personality and sex are tradable commodities.

Behind every myth, fairy tale, and legend—hidden within the art, song, and structures of ancient times—is an encoded layer of wisdom, science, and truth passed down throughout history. This book will examine how information went “viral” long before the Internet, and served as the foundation for mythology, sacred architecture, and symbolic imagery throughout the ancient world. Viral Mythology reveals: How primitive and ancient cultures conveyed cutting-edge scientific knowledge in their origin stories and myths Why esoteric knowledge was hidden in symbols, art, and architecture during times of religious oppression and persecution How stories, songs, and art served to describe actual historical events Why diverse civilizations told the same stories and created the same art with common themes and symbols, despite no apparent communication From the great myths of the Greek, Roman, and Norse to the texts of the world’s major religions, from folklore and fairy tales of old to sacred edifices and monuments, from cave paintings to the mysterious symbology of the Tarot, Viral Mythology uncovers the information highway of the past, and explores how it affects the more modern methods of communication today. It all began once upon a time....