The first goal of this book is to provide the patient with accurate information. The second goal is to show how a combination of "orthodox medicine" and complementary therapies can help people through their cancer diagnosis, treatment and follow up. Early chapters apply to all women diagnosed with cancer, followed by chapters for each specific site of disease. Then follow chapters on chemotherapy, radiotherapy, pain management, complementary therapies and spiritual approaches. The book incorporates a novel "4 cusp" approach, which enables women to explain to their families where they are in the process.

Taking patients through all aspects of cancer care, this book provides specific, accurate information on various tumour types and treatment modalities, surgery, chemotherapy, radiotherapy, and complementary therapy. Unlike many patient guides, it explores holistic health and wellbeing as well as psychological responses, recognising distress and the treatments and interventions to help.World-renowned surgeon Richard Smith, founder of Uterine Transplant UK, uses inclusive, accessible language as well as pictorial models of doctor-patient communication to describe all of the common gynaecological cancers, their epidemiology, staging and treatment. Speaking directly to the patient and her family, he discusses not only the medical but also the psychological, spiritual and religious aspects to coping and living with a cancer diagnosis.Written for patients and their families, this book will also be an invaluable resource for nurses, and medical and nursing students, working within the field of gynaecological cancers.All royalties from this book are being donated by the authors to Womb Transplant UK, Registered Charity no.1138559. For more information please visit wombtransplantuk.org/.

The latest edition of An Atlas of Gynecologic Oncology continues its coverage of the innovative techniques in investigation and surgery on the brink of becoming established as part of the gynecologic surgeon’s repertoire, now including the exciting developments in uterine transplantation.

HAS "THE CHANGE" COME TOO SOON ? DON’ T WORRY, YOU’RE NOT ALONE! Every year more than two million women enter early menopause and find themselves suddenly dealing with a host of unforeseen (and little discussed) issues. In Before Your Time, Evelina Weidman Sterling and Angie Best-Boss provide expert advice and answer all your questions, including: Is it safe to start hormone therapy in your thirties rather than in your fifties? What are your fertility options? How can you combat the long-term effects of early menopause, such as a greater risk of osteoporosis, heart disease, and diabetes? How will early menopause affect your relationships? Your sex life? Your sense of self? Before Your Time brings you the best-researched, most up-to-date answers to all those tough-to-ask questions. The good news: there is more research and information available now than ever before to keep you safe and healthy, and it’s all right here!

This book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.

Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is an important signaling route that regulates several cell functions. PI3K/AKT/mTOR pathway is a crossroad of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and proliferation, apoptosis, and angiogenesis. Disruptions in the Akt‑regulated pathways and alterations in PTEN expression are associated to Reactive oxygen species (ROS) homeostasis and different types of cancer. Genomic studies have shown that activating mutations in oncogenes as well as inactivating mutations in tumor suppressor genes are present across a variety of malignancies, including constitutive activation of the PI3K/AKT/mTOR pathway. The regulation of the Akt signaling pathway renders multiple challenges and valuable therapeutic targets. The discovery process of Akt, PDK1 and mTOR synthetic and natural products as inhibitors or immune checkpoint inhibitors using various strategies, could led to the identification of small molecule inhibitors with great selectivity, low side‑effects and also low toxicity regarding drug development.

Signaling pathways is a comprehensive mechanism by which all cellular organisms communicate internally and externally with their microenvironment. This is a highly complex and exact process. Errors in signaling pathways and in the processing of cellular information are known to be responsible for the majority of diseases including cancer, inflammatory and neurological disorders. Knowledge gained from the better understanding of signaling pathways will help in elucidating disease processes and will assist in development and design of novel targeted treatment therapies to combat human diseases and disorders. Heat shock proteins (HSP) are uniquely involved in a number of critical signaling pathways. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the "classic" papers as well as perspectives on future directions for the field.