The chemist has a vast range of high-tech catalysts to use when working in fine chemical synthesis but the catalysts are generally hard to use and require both time, skill and experience to handle properly. The Catalysts for Fine Chemical Synthesis series contains tested and validated procedures which provide a unique range resources for chemists who work in organic chemistry. "... of great value to synthetic organic chemists..." (The Chemists, Summer 2003) Volume 3 in the series focuses on catalysts for carbon-carbon bond formation and presents practical and detailed protocols on how to use sophisticated catalysts by the "inventors" and "developers" who created them. The combination of protocols and review commentaries helps the reader to easily and quickly understand and use the new high-tech catalysts.

Volume 3 covers carbon-to-carbon single bond forming reactions involving sp3, sp2 and sp carbon centers, but only those which do not involve additions to C-X &pgr;-bonds. The volume first compares and contrasts the alkylation reactions of all types of sp3 carbon nucleophiles and also covers vinyl and alkynyl carbanions. Following on from Volume 2, a separate section covers Friedel-Crafts alkylation reactions, which is complemented by discussions of polyene cyclizations and electrophilic transannular cyclizations in synthesis. Coupling reactions leading to &agr;-bond formation, and involving all types of combinations ofsp3, sp2 and sp carbon centers are next covered, including those reactions based on pinacol, acyloin and phenol oxidative coupling reactions, and also the Kolbe reaction. Rearrangement reactions, leading to carbon-to-carbon &agr;-bond formation, are often used in a clever manner in synthesis. The volume includes all those rearrangement reactions based on intermediate carbonium ions and carbanions, and also includes the benzil-benzilic acid and the Wolff rearrangements. The volume closes with coverage of carbonylation reactions, and the use of carbene insertion reactions into the C-H bond in synthesis.

Handbook of Reagents for Organic Synthesis Reagents, Auxiliaries and Catalysts for C-C Bond Formation Robert M. Coates and Scott E. Denmark The University of Illinois, Urbana, USA Recognising the critical need for bringing a handy reference work that deals with the most popular reagents in synthesis to the laboratory of practising organic chemists, the Editors, of the acclaimed Encyclopedia of Reagents for Organic Synthesis (EROS) have selected the most important and useful reagents employed in contemporary organic synthesis. The Handbook of Reagents for Organic Synthesis; Reagents Auxiliaries and Catalysts for C-C Bond Formation, provides practical and concise information on a diverse group of reagents. To familiarise the user with the spectrum of reagents contained within this volume, the editors have subdivided more than 200 entries into 22 classes based on their chemical structures and function. The articles, arranged alphabetically, contain all of the information found in EROS as well as expanded reagents listings. In addition, new listings of recently published review articles and monographs are included, as well as relevant Organic Syntheses procedures that deal with either the preparations or reactions of the featured reagents. This comprehensive and well referenced handbook will prove of great value to all practitioners in the field of organic chemistry.

The construction of C-X (X = C, N, S) bonds is an important research content in the field of organic synthesis and drug preparation. Focusing on the green construction of the core skeleton of functional fine chemicals, the team has carried out research on green synthesis and catalytic reactions of fine chemicals, realized the effective synthesis of high value-added fine chemicals, and obtained a series of new systems of transition metal palladium and copper-catalyzed halogenated aromatic hydrocarbons involved in C-C and C-N coupling reactions; realized the efficient preparation of biphenyl, arylamine and aryl thioether compounds using water as solvent. Aiming at atomic economy, we realized the new method of direct C-H functionalization of arenes to construct C-C and C-S bond formation, as well as the construction of structurally complex functional molecular skeletons through one-pot multi-step reactions, laying a solid foundation for the application of fine organic synthesis technology in the fields of pharmaceutical intermediates, agrochemicals and optoelectronic materials, forming a distinctive research direction of fine chemical synthesis technology and it has formed a distinctive research direction of fine chemical synthesis technology and a stable R&D team, and improved the technical level of preparation of high value-added fine chemicals. He has published a total of 30 academic papers, including 27 SCI papers.

The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part B describes the most general and useful synthetic reactions, organized on the basis of reaction type. It can stand-alone; together, with Part A: Structure and Mechanisms, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for students and exercise solutions for instructors.

With contributions by numerous experts

This book introduces the major methods of creating carbon-carbon and carbon-nitrogen bonds, along with functional group interconversions.

The demand for increasingly clean and efficient chemical syntheses is continuously becoming more urgent from both an economic and an environmental standpoint. So-called green technologies are looking for alternatives, yet they focus on large quantities of hazardous even toxic solvents. One could even say that the best solvent is no solvent. It is against this background that chemical synthesis without the use of solvents has increasingly developed into a powerful methodology. Once the chemical reactivity is increased, the amount of initial substances needed is reduced; in particular it removes the need for the complex recycling and disposal of solvents. In this book, the third in our open "Green Chemistry" series, Koichi Tanaka describes the latest developments in this exciting field. Packed with advice on applications, this will be equally useful to practitioners in research as well as process chemists in industry, such that it is sure to become an invaluable reference source.