In this second edition of a best-selling handbook all the chapters have been completely revised and updated, while four completely new chapters have been added. In order to meet the needs of the practitioner, emphasis is placed on describing precisely the technology and know-how involved. Adopting a didactic and comprehensible approach, the book guides the reader through theory and applications, thus ensuring its warm welcome among the scientific community. An excellent, essential and exhaustive overview.

The demand for increasingly clean and efficient chemical syntheses is continuously becoming more urgent from both an economic and an environmental standpoint. So-called green technologies are looking for alternatives, yet they focus on large quantities of hazardous even toxic solvents. One could even say that the best solvent is no solvent. It is against this background that chemical synthesis without the use of solvents has increasingly developed into a powerful methodology. Once the chemical reactivity is increased, the amount of initial substances needed is reduced; in particular it removes the need for the complex recycling and disposal of solvents. In this book, the third in our open "Green Chemistry" series, Koichi Tanaka describes the latest developments in this exciting field. Packed with advice on applications, this will be equally useful to practitioners in research as well as process chemists in industry, such that it is sure to become an invaluable reference source.

The solvent-free approach provides green and alternative synthetic methods for obtaining diverse bioactive heterocycles. The solvent is frequently the primary component of synthetic protocol and contributes to significant waste. Additionally, its removal processes are energy intensive and substantial. This book explores different solvent-free procedures for efficiently synthesising heterocyclic analogues of immense biological importance and other applications.

Solvent-Free Methods in Nanocatalysis Discover solvent-free approaches for the synthesis of nanocatalysts as well as various catalytic transformations in this unique one-stop resource Solvent-free methods have attracted wide attention in organic synthesis and catalysis as a promising approach towards “greener” and more sustainable chemical transformations. In this regard, nanocatalysis has seen particular growth in recent years. Solvent-Free Methods in Nanocatalysis gives an in-depth overview of nanocatalysts and their catalytic applications using solvent-free methods. After a brief introduction, it covers various synthetic techniques for the preparation of nanocatalysts and supports using solvent-free methods, e.g. ball-milling, microwave- and plasma-assisted methods. The book discusses in detail different catalyst classes, such as metal oxides, doped and functionalized nanocarbons, as well as nitride- and silica-based materials to help researchers to understand the efficiency and nature of these catalysts/supports based on their chemical structure. In the book readers will also find: A brief account of the history, challenges, and recent advances in the field Detailed discussion of advantages and disadvantages of solvent-free techniques for nanocatalyst preparation Treatment of important solvent- and catalyst-free organic transformations (i.e. oxidation, coupling and multicomponent reactions) A chapter on supported ionic liquids for solvent-free catalysis Written by leading researchers in the field, Solvent-Free Methods in Nanocatalysis is a useful reference for researchers and students working in organic synthesis, catalysis, and nanomaterials science.

The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively

Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.

In most cases, every chemist must deal with solvent effects, whether voluntarily or otherwise. Since its publication, this has been the standard reference on all topics related to solvents and solvent effects in organic chemistry. Christian Reichardt provides reliable information on the subject, allowing chemists to understand and effectively use these phenomena. 3rd updated and enlarged edition of a classic 35% more contents excellent, proven concept includes current developments, such as ionic liquids indispensable in research and industry From the reviews of the second edition: "...This is an immensely useful book, and the source that I would turn to first when seeking virtually any information about solvent effects." —Organometallics

It is well-established that organic synthetic processes have been at the core of the chemical industry for hundreds of years, in the production of organic compounds with a wide range of applications. However, we are becoming increasingly aware of the hazardous substances used and generated by these chemical processes. The field of organic synthesis has undergone profound changes to switch to equally efficient, but more sustainable processes that avoid the extensive use of toxic and hazardous reagents and solvents, harsh reaction conditions and expensive and sophisticated catalysts. Explaining methods for carrying out chemical syntheses without the use of catalysts, this book shows how avoiding catalysts during synthesis can mean less use of toxic chemicals, environmentally damaging chemicals or endangered elements and lower costs. It is an important reference for chemists involved in organic synthesis, as well as for green chemists.

The conventional solvents used in chemical, pharmaceutical, biomedical and separation processes represent a great challenge to green chemistry because of their toxicity and flammability. Since the beginning of “the 12 Principles of Green Chemistry” in 1998, a general effort has been made to replace conventional solvents with environmentally benign substitutes. Water has been the most popular choice so far, followed by ionic liquids, surfactant, supercritical fluids, fluorous solvents, liquid polymers, bio-solvents and switchable solvent systems. Green Solvents Volume I and II provides a throughout overview of the different types of solvents and discusses their extensive applications in fields such as extraction, organic synthesis, biocatalytic processes, production of fine chemicals, removal of hydrogen sulphide, biochemical transformations, composite material, energy storage devices and polymers. These volumes are written by leading international experts and cover all possible aspects of green solvents’ properties and applications available in today’s literature. Green Solvents Volume I and II is an invaluable guide to scientists, R&D industrial specialists, researchers, upper-level undergraduates and graduate students, Ph.D. scholars, college and university professors working in the field of chemistry and biochemistry.

Green Sustainable Process for Chemical and Environmental Engineering and Science: Sonochemical Organic Synthesis focuses on purification and extraction of organic, biological, and medicinal compounds using sonochemistry. It provides readers with an understanding of green ultrasound-assisted chemical synthesis for industrial applications. This book systematically explores the application of ultrasound in organic synthesis of all types and includes stereoselectivity, regioselectivity, oxidations, reductions, protection, deprotection, additions, condensation, coupling, C-X bond formation, named reactions, heterocyclics, biological drugs, and fluoroorganics over conventional techniques. A brief introduction to the parameters which influence the process, solvent-effects, supported reagents and catalysis and the pros and cons to the practical use of sonochemical protocols in organic synthesis are also discussed. This book provides overview on the applications of sonochemical technology for the sustainable and environmentally friendly development of synthetic methodologies for organic and pharmaceutical chemistry. Sonochemical Organic Synthesis is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in modern organic chemistry and medicinal chemistry. - Offers a broad overview of ultrasonics-assisted green organic synthesis - Discusses sonochemical technology for green organic synthesis and biological medicinal importance - Gives detailed accounts of numerous industrial applications, including polymers, pharmaceutical, fluoroorganics, biofuel, carbon, and more - Includes a description of significant factors and challenges in ultrasonics-assisted green organic synthesis - Lists recent developments in the use of sonochemical technology in organic chemist