One of the hallmarks of the 21st century medicine is the emergence of digital therapeutics (DTx)—evidence-based, clinically validated digital technologies to prevent, diagnose, treat, and manage various diseases and medical conditions. DTx solutions have been gaining interest from patients, investors, healthcare providers, health authorities, and other stakeholders because of the potential of DTx to deliver equitable, massively scalable, personalized and transformative treatments for different unmet medical needs. Digital Therapeutics: Scientific, Statistical, Clinical, and Regulatory Aspects is an unparalleled summary of the current scientific, statistical, developmental, and regulatory aspects of DTx which is poised to become the fastest growing area of the biopharmaceutical and digital medicine product development. This edited volume intends to provide a systematic exposition to digital therapeutics through 19 peer-reviewed chapters written by subject matter experts in this emerging field. This edited volume is an invaluable resource for business leaders and researchers working in public health, healthcare, digital health, information technology, and biopharmaceutical industries. It will be also useful for regulatory scientists involved in the review of DTx products, and for faculty and students involved in an interdisciplinary research on digital health and digital medicine. Key Features: Provides the taxonomy of the concepts and a navigation tool for the field of DTx. Covers important strategic aspects of the DTx industry, thereby helping investors, developers, and regulators gain a better appreciation of the potential value of DTx. Expounds on many existing and emerging state-of-the art scientific and technological tools, as well as data privacy, ethical and regulatory considerations for DTx product development. Presents several case studies of successful development of some of the most remarkable DTx products. Provides some perspectives and forward-looking statements on the future of digital medicine.

Digital Therapeutics for Mental Health and Addiction: The State of the Science and Vision for the Future presents the foundations of digital therapeutics with a broad audience in mind, ranging from bioengineers and computer scientists to those in psychology, psychiatry and social work. Sections cover cutting-edge advancements in the field, offering advice on how to successfully implement digital therapeutics. Readers will find sections on evidence for direct-to-consumer standalone digital therapeutics, the efficacy of integrating digital treatments within traditional healthcare settings, and recent innovations currently transforming the field of digital therapeutics towards experiences which are more personalized, adaptable and engaging. This book gives a view on current limitations of the technology, ideas for problem-solving the challenges of designing this technology, and a perspective on future research directions. For all readers, the content on cultural, legal and ethical dimensions of digital mental health will be useful. - Gives a comprehensive overview of the field of digital therapeutics and research on their efficacy, effectiveness, scalability and cost-effectiveness - Introduces novel directions in which digital therapeutics are currently being extended, including personalized interventions delivered in real-time - Reviews important considerations surrounding digital therapeutics, including how they can be monetized and scaled, ethical issues, cultural adaptations, privacy and security concerns, and potential pitfalls

Digital Health: Telemedicine and Beyond describes practical ways to use digital health tools in clinical practice. With a strong focus on case studies and patient outcomes, this title provides an overview of digital medicine, terms, concepts, and applications for the multidisciplinary clinical practitioner. Chapters provide a concise, yet comprehensive understanding of digital health, including telemedicine, mHealth, EHRs, and the benefits and challenges of each. The book gives insights on risks and benefits associated with storing and transmitting patient information via digital tools and educates clinicians in the correct questions to ask for advocacy regarding state laws, scope of practice, and medicolegal implications. It also addresses the ethical and social challenges that digital health raises, how to engage patients to improve shared decision-making models and how digital health tools can be integrated into clinical practice. This book is a valuable resource for clinicians and medical educators of all health professions, including physicians, physician associates, nurses, pharmacists, physical therapists, occupational therapists, speech therapists, students, and all those who wish to broaden their knowledge in the allied field. - Provides a clinical perspective on digital health - Written by clinicians for clinicians with the patient in mind - Describes practical ways to use digital health tools in clinical practice - Includes case studies to incorporate workflows into practice to improve patient outcomes

Mental health researchers are increasingly looking towards digital health tools to gather day-to-day lived experiences of people living with mental health conditions, by using apps and wearable devices complementing episodic clinical assessments. One of the key goals of collecting longitudinal real-world multimodal data (RWD) is to help build personalized computational models that may help explain the heterogeneity in clinical outcomes, mechanisms of action, and pathophysiology of mental health disorders across individuals.

A practical action plan for reinventing healthcare in a post-pandemic world—from a physician-entrepreneur who works with Fortune 500 companies. If the healthcare system were an emperor, Covid-19 tragically revealed that it had no clothes. Healthcare had to adapt, and quickly―sparking a dramatic acceleration of virtual care, drive-through testing, and home-based services. In the process, old rules were rewritten and, perhaps surprisingly, largely in a good way for patients. To succeed in the post-pandemic world, all of us―patients, caregivers, providers, employers, investors, technologists, and policymakers―need to understand the new healthcare landscape and change our strategies and behaviors accordingly. In Care After Covid, practicing physician and business leader Dr. Shantanu Nundy—Chief Medical Officer of Accolade, which provides technology-enabled health services to Fortune 500 companies as well as small businesses―lays out a comprehensive plan to transform healthcare along three dimensions: Distributed: healthcare will happen where health happens. It will shift from where doctors are to where patients are—at home, in the community, and increasingly on their phones. Digitally enabled: healthcare and the relationships that are central to care will be strengthened by data and technology. It will shift from being siloed to connected, from being episodic to continuous, from one-size-fits-all to more personalized. Decentralized: healthcare decisions and resources will be in the hands of those closest to care. The power to determine who gets care and how they get it will shift away from governments and insurance companies to communities, employers, doctors, and patients. Filled with firsthand insights and stories from the frontlines of healthcare—as well as innovative solutions that were proven effective before and during the pandemic—Care After Covid shows all stakeholders in the healthcare ecosystem exactly what needs to change and, more importantly, how to do it. The time to act is now. We can’t afford not to.

The authoritative textbook on the principles and practical applications of biopharmaceutics and pharmacokinetics Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics has been the standard textbook in its field for over 40 years. This eighth edition includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition has been expanded and revised to include advancements in biopharmaceutics and pharmacokinetics. The chapter sequence has been reorganized into four main sections, providing a more logical sequence for students. The textbook starts with fundamental concepts, followed by application of these principles to optimize drug therapy and to the rational development of drug products. Each chapter includes theoretical concepts with practical examples and clinical applications. Frequently asked questions provide a discussion of overall concepts. Features: Expanded and revised chapters to include scientific advances in biopharmaceutics and pharmacokinetics Four main sections providing a natural buildup of knowledge: introduction to biopharmaceutics and pharmacokinetics, fundamentals of biopharmaceutics, pharmacokinetic calculations, clinical pharmacokinetics and pharmacodynamics, and biopharmaceutics and pharmacokinetics in drug product development Additional chapters for this edition include: o Physiological factors related to drug absorption o Approaches to pharmacokinetics and pharmacodynamics calculations o Novel and complex dosage Forms o Clinical Development and Therapeutic Equivalence of Generic Drug and Biosimilar Products o Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development Additional information on drug therapy, drug product performance, and other related topics Frequently asked questions, practice problems, clinical examples and learning questions