Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.

Integrates the latest theory, methodology and applications related to the design and analysis of repeated measurement. The text covers a broad range of topics, including the analysis of repeated measures design, general crossover designs, and linear and nonlinear regression models. It also contains a 3.5 IBM compatible disk, with software to implem

Multilevel Modeling Methods with Introductory and Advanced Applications provides a cogent and comprehensive introduction to the area of multilevel modeling for methodological and applied researchers as well as advanced graduate students. The book is designed to be able to serve as a textbook for a one or two semester course in multilevel modeling. The topics of the seventeen chapters range from basic to advanced, yet each chapter is designed to be able to stand alone as an instructional unit on its respective topic, with an emphasis on application and interpretation. In addition to covering foundational topics on the use of multilevel models for organizational and longitudinal research, the book includes chapters on more advanced extensions and applications, such as cross-classified random effects models, non-linear growth models, mixed effects location scale models, logistic, ordinal, and Poisson models, and multilevel mediation. In addition, the volume includes chapters addressing some of the most important design and analytic issues including missing data, power analyses, causal inference, model fit, and measurement issues. Finally, the volume includes chapters addressing special topics such as using large-scale complex sample datasets, and reporting the results of multilevel designs. Each chapter contains a section called Try This!, which poses a structured data problem for the reader. We have linked our book to a website (http://modeling.uconn.edu) containing data for the Try This! section, creating an opportunity for readers to learn by doing. The inclusion of the Try This! problems, data, and sample code eases the burden for instructors, who must continually search for class examples and homework problems. In addition, each chapter provides recommendations for additional methodological and applied readings.

Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.

Here is an essential introduction to the latest arsenal of methods available to students and practicing scientists who undertake longitudinal and other studies that collect repeated measurements for subsequent analysis. The book presents the general context of repeated measurements and introduces--through a large number of concrete examples, including data tables--the three basic types of response variables: continuous (normal), categorical and count, and duration variables. The ways in which such repeated observations are interdependent, through heterogeneity and time dependence, are discussed. The author also develops a useful framework for constructing suitable models and introduces concepts of multivariate distributions and stochastic processes necessary to appreciate the underpinnings and power of repeated measurements analyses. The book concludes with an extensive bibliography of the repeated measurement literature that will aid readers interested in finding source materials. Written by a distinguished statistician, this book is a much-needed and practical guide to the most current repeated measurements techniques available. It will be welcomed by students, applied statisticians, biostatisticians, biologists, medical researchers, econometricians, sociologists, and psychologists.

Providing easy-to-use R script programs that teach descriptive statistics, graphing, and other statistical methods, Learning Statistics Using R shows readers how to run and utilize R, a free integrated statistical suite that has an extensive library of functions. Schumacker’s comprehensive book describes the processing of variables in statistical procedures. Covering a wide range of topics, from probability and sampling distribution to statistical theorems and chi-square, this introductory book helps readers learn not only how to use formulae to calculate statistics, but also how specific statistics fit into the overall research process. Each chapter includes discussion and explanations, tables and graphs, and R functions and outputs to enrich readers' understanding of statistics through statistical computing and modeling.